Sema/Thriz/Reta choices

[Here2Learn]

Currently I’m on Sema, up to 1.25mg/week and have been losing an average of 1lb/week or less. I started at a medspa, just shifted to Skye and now researching China direct. My inflammation can vary widely so the scale jumps all over the place. Sema has helped with inflammation and I’m looking into running BPC/TB for. 6-8 week protocol to see if it helps more and than a series of Thymosin Alpha 1 after that.

My question is with the lower pricing of China direct Tirz/Reta is more affordable so it has become and option. Sema makes me SO tired and I feel like some weeks it works really well and other weeks not as much. If you were to change what would you choose? I’ve researched all of them pretty extensively so I know the pro/cons but looking for people who have switched and what they liked or don’t like.

 

[clearheaded]

TIRZ is popular for a reason.

also dont take BPC for inflammation. also dont take THYMOSIN peptides for inflammation as actually can make things worse(as theory behind using it is INCREASING inflammatory response to help heal). its like taking a vaccine adjuvant all the time and really can mess with ur immune system which seems unwise...

get some quality fish oil with high EPA and take baby asprin if have a flair up.

your weight can vary due to how much food in your gut as sema slows down, take a probiotic.. also keep an eye on sodium intake as likely alot of the 'inflammation weight" is simply sodium.

 

[Here2Learn]

@clearheaded I’ve read up on the water retention from both but I’m trying to heal some different issues. Both, from the literature I’ve read, are anti inflammatory which is different than water retention. I am here to learn so will definitely research what you are talking about though.

My weight can vary 5lbs in a day, not a slow gut kind of thing. My calf can swell 2” as an example. Doctors have been stumped but I think I’ve started to dial in on what is going on.

 

[ZavenRains]

I'm switching back to Sema from Tirz. While Tirz is virtually side effect free for me I'm just not losing enough as the food cravings are still there. But like you sema lethargy was definitely an issue if I dose too high. Frustrating!

 

[Here2Learn]

@ZavenRains

The exhaustion is so frustrating, I become almost non functional. I’m hoping Tirz might work a little better for me but have looked at Reta also. Even debating stacking a bit of Reta for an energy boost. I’m wanting to add anything different slowly and one at a time so trying to plan out how I want to go about this.

 

[PaintDrinker]

@ZavenRains

The exhaustion is so frustrating, I become almost non functional. I’m hoping Tirz might work a little better for me but have looked at Reta also. Even debating stacking a bit of Reta for an energy boost. I’m wanting to add anything different slowly and one at a time so trying to plan out how I want to go about this.

Tirzepatide seems to be a lot more effective at 10-15 mgs. I’m on 15mg tirz and have 0 hunger 0 side effects. Reta was horrible for me. Max dose 12mg had my heart rate through the sky 24/7 and very little hunger suppression. It felt like maybe 5mg tirz, and 5mg tirz does almost nothing for me.

Sema worked well at max dose for me but I was also shitting blood constantly and farting like crazy.

Tirz is more effective than sema for me at the max dose.

Reta was a horrible experience, high heart rate, high fasted bg, minimal hunger suppression at max dose. (My experience does not mean it’s the same for everyone)

 

[Here2Learn]

@PaintDrinker I’ve definitely read up on the accelerated heart rate and if I use Reta was planning on going very slowly. I’m leaning towards Tirz at this point. How was your energy levels Sema vs Tirz?

 

[ZavenRains]

@ZavenRains

The exhaustion is so frustrating, I become almost non functional. I’m hoping Tirz might work a little better for me but have looked at Reta also. Even debating stacking a bit of Reta for an energy boost. I’m wanting to add anything different slowly and one at a time so trying to plan out how I want to go about this.

I may try Reta next also

 

[TheHaus88]

I like Sem for appetite suppression. Works very well. The first time I felt nothing but then again I think I bent the pin and didn't even inject.

A year later I tried again. I felt it in my brain creeping up. Hunger suppression was stronger than M2. Digestion stopped, fat loss was great. Hunger almost zero. Satiated feeling was long lasting.

I've stacked Sem with Tirz.

Tirz has far less appetite suppression. I can eat on Tirz. Fuller feeling after meals once I hit 5mg.

About to pull the trigger on Ret, the way Lilly is acting in the courts it's probably going to launch soon and be the New King.

I like Sem but hate the gastro paralysis.

Going to stick with Tirz until Ret order.

I found this today on YT


View: https://youtu.be/UeX82sq8Ges

 

[Clover 0080]

Tirzepatide seems to be a lot more effective at 10-15 mgs. I’m on 15mg tirz and have 0 hunger 0 side effects. Reta was horrible for me. Max dose 12mg had my heart rate through the sky 24/7 and very little hunger suppression. It felt like maybe 5mg tirz, and 5mg tirz does almost nothing for me.

Sema worked well at max dose for me but I was also shitting blood constantly and farting like crazy.

Tirz is more effective than sema for me at the max dose.

Reta was a horrible experience, high heart rate, high fasted bg, minimal hunger suppression at max dose. (My experience does not mean it’s the same for everyone)

From what i understand about the 3 Tirz is the most effective overall but reta is better for weightloss alone...not hunger suppression. So i guess theoretically you would shred MORE weight on reta alone but be ravenously hungry.

Tirz would be better for the over eaters but reta would be a better choice for someone who just has a slow metabolism.

 

[TheHaus88]

From what i understand about the 3 Tirz is the most effective overall but reta is better for weightloss alone...not hunger suppression. So i guess theoretically you would shred MORE weight on reta alone but be ravenously hungry.

Tirz would be better for the over eaters but reta would be a better choice for someone who just has a slow metabolism.

GLPs have graduated to the "your mileage may vary" category as more people try all of the compounds.

They all work great, they all have their side effects and some people tolerate them more than others.

Many more are coming. Pfizer recently announced that they threw their hat into the ring and we should see something from them by 2028.

As I said in late 2020 I'll say it again... Invest in pharma stocks.

 

[playerdev2024]

TIRZ is popular for a reason.

also dont take BPC for inflammation. also dont take THYMOSIN peptides for inflammation as actually can make things worse(as theory behind using it is INCREASING inflammatory response to help heal). its like taking a vaccine adjuvant all the time and really can mess with ur immune system which seems unwise...

get some quality fish oil with high EPA and take baby asprin if have a flair up.

your weight can vary due to how much food in your gut as sema slows down, take a probiotic.. also keep an eye on sodium intake as likely alot of the 'inflammation weight" is simply sodium.

tirz is my go-to for painless knees.. not deca, not NSAIDs.
1-2mg per week is all i (k)need.

 

[playerdev2024]

I like Sem for appetite suppression. Works very well. The first time I felt nothing but then again I think I bent the pin and didn't even inject.

A year later I tried again. I felt it in my brain creeping up. Hunger suppression was stronger than M2. Digestion stopped, fat loss was great. Hunger almost zero. Satiated feeling was long lasting.

I've stacked Sem with Tirz.

Tirz has far less appetite suppression. I can eat on Tirz. Fuller feeling after meals once I hit 5mg.

About to pull the trigger on Ret, the way Lilly is acting in the courts it's probably going to launch soon and be the New King.

I like Sem but hate the gastro paralysis.

Going to stick with Tirz until Ret order.

I found this today on YT


View: https://youtu.be/UeX82sq8Ges

ret + tirz = GAME CHANGER!

 

[playerdev2024]

From what i understand about the 3 Tirz is the most effective overall but reta is better for weightloss alone...not hunger suppression. So i guess theoretically you would shred MORE weight on reta alone but be ravenously hungry.

Tirz would be better for the over eaters but reta would be a better choice for someone who just has a slow metabolism.

yes.. i feel ret+tirz is a good stack...

ret - for the metabolic boost and weight gain
tirz - for the reduction in 'food noise'

without tirz i want to eat the whole fridge and the whole bakery aisle.

 

[Ghoul]

Sema is very cost effective, potent, and the most brutal sides.

Tirz is much, much lighter on sides, and can be as effective for weight loss, but not always, as Sema. Definately. a "premium" option compared to Sema. Tiredness and GI issues are experienced far less.

Personally I would be wary of stacking unless you hit max dose on any one compound and need more weight loss.

Keep in mind, that like insulin, you should expect to go on a maintenance dose permanently, so keep affordability in mind.

I'd try Tirz, and if that gets you to your goal weight without plateauing, stick with it.

 

[TheHaus88]

ret + tirz = GAME CHANGER!

What dosage? Can you link to yours or others experience?

 

[playerdev2024]

What dosage? Can you link to yours or others experience?

you have to play with it... but i've had success with as little as:

per week..

0.5mg tirz
2mg reta

first week, i definitely felt the reduction in food noise, reduced inflammation.. water loss..

as ghoul states, probably start with just tirz(maybe 0.5mg) and go from there.

you have to remember to get in your protein requirements(plus a little more)..
its VERY EASY to not eat on this stuff...

most experiences can be found on the many reddit subs.. id look there.. keep in mind, many there are 'obese' who dont lift and expect magic...

coupled with PEDs, increased protein intake, and consistent training, cutting on GLP1s is a 'cheat code'
much more so than DNP.

 

[BamaCrazy]

ret + tirz = GAME CHANGER!

I just started stacking today. I am already on 7.5mg Tirz which I might decrease now. And started 2mg Reta this morning. Resting HR and BP are ok. Tirz was making me exhausted after injection for 2-3 days. Yesterday I was tired. Today I’m a little wired. But that could be placebo but time will tell.

 

[playerdev2024]

I just started stacking today. I am already on 7.5mg Tirz which I might decrease now. And started 2mg Reta this morning. Resting HR and BP are ok. Tirz was making me exhausted after injection for 2-3 days. Yesterday I was tired. Today I’m a little wired. But that could be placebo but time will tell.

yes... tirz seems to be lethargy in a bottle.. thats why i like to start very low, then work my way up..
as long as i can knock out the 'food noise' i am good...

 

[Clover 0080]

What dosage? Can you link to yours or others experience?

I was dong 10mg Tirz for 6 months then did
5mg Tirz 2mg Reta
5mg Tirz 4mg Reta
Now im at my goal weight so im gonna drop the reta and keep the 5 Tirz for maintenance