Ruper said:He does have a point though, which is that we may not be using the correct model and that the 1/2 life is meaningless. However, for us interested in replicating that graph, the decay model works and I have not seen another model that does as good a job. In addition, any other model could not decay substantially faster than a radioactive decay model with 1/2 life of 7-8 days and still fit those data.
I guess the only way to see the “true” graph of testosterone decay by direct blood testing is to take a masochistic eunuch and keep them off of testosterone for six months and then inject them and take blood tests. LOL, any volunteers?
Also I should mention that the time to steady-state is partially contolled by the 1/2 life. For a 4 day 1/2 life one would only have to wait 3 weeks to reach steady-state with weekly injections and not front-loading the first injection. For 8 day 1/2 life it is ~5 weeks (although ~3 weeks with a doubling of the first injection).
Yea, looking at the graphs you’re right.
Hey I just got a cool result. Try doubling up the first injection and put in a 1/2 life of 4 days with weekly injects - I don't think anyone would do that in practice if they thought the 1/2 life was only 4 days!
Hehe, another good point. If the half life was 4 days then no one would ever double the first dose because absorption would look something like the attached graph.
View attachment 6416
Note, I know, there are no peaks...this is a work in progress. Still it works really well.
BTW, I think I'm gonna go ahead an put in a ramp up in my calculator. Shouldn't be too hard. And it will get rid of the peaks.
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