Thank you for your response.
The base I used for this one is a pluronic lecithin organogel base; and I dosed it at 2% w/w testosterone. I have another non-PLO vanishing base that I received after I made his cream; and I found it to be less irritating to the skin.
Both of the bases, that I have, have been studied against others, VersaBase included; and these were found to have greater absorption at 12 hours than VersaBase. I'm sorry, but I can't divulge the manufacturer because it is not available for unlicensed purchase.
The dose metering container is FDA approved for topical pharmaceutical dispensing; and dispenses 1ml per application.
My friend was using 1ml per day applied to alternating sites, including: both wrists, both upper arms, and both inner thighs. I decided to exclude scrotal application because I would not use this method; and I wouldn't ask someone to do something I won't do myself.
At 1ml/day, he was using 20mg testosterone in the 2% cream. He had his blood drawn at 27days total therapy, on the morning before the 28th dose.
This was 140mg testosterone per week, which gave him a total serum testosterone of 713ng/dl reported by LabCorp. His serum testosterone before using this cream was 193.
Anecdotally, he stated he felt much better. We did not discuss erections, libido, etc.
I appreciate the response.
Correct me if I'm wrong but I believe Androgel is PLO based gel and it is a pharmaceutical product which is well known to have erratic absorption across various skin types and a high chance of transference to others.
The studies I've found concerning other compounded testosterone PLO bases have shown and absorption efficacy of between 6%-50% from individual to individual as well as a high chance of transference of testosterone to others.
PLO based gels can irritate particular skin types as well as skin on certain areas of the body, especially with prolonged use.
Are there new PLO bases that mitigate these problems?
Can you point to the data or link some studies that specifically shows a PLO base testosterone gel is superior to versabase T or other transdermal T-creams?
PLO base drug delivery systems efficacy concerning absorption are proven to vary depending on the particular drug being delivered transdermally. While PLO carrier bases may be more efficient in transdermally administering drugs such as Ketamine, I believed the contrary is true with testosterone.
Testosterone cream bases such as the one used in Pentravan are shown to be 1.6-1.8 times more efficient at absorption through all dermal membranes when compared to PLO based Testosterone delivery systems in the medical literature I've read.
Why not choose the scrotal application method? Scrotal application is widely used and regarded as superior to all other forms of delivery by the leading HRT physicians in the medical field.
Aside from scrotal T-creams being known to elevate DHT slightly higher than other delivery systems (good for libido, bad for prostate) I don't know why you wouldn't consider it. What are your safety concerns?
Compounded versabase creams are, from my understanding, much more efficient at delivering testosterone scrotally as opposed to other current testosterone transdermal delivery system used on other parts of the body. Is there literature which states otherwise?
The scrotum is a much more permeable dermal layer for steroids than other areas of the body.
Comparing Testosterone based PLO gels topically applied to the wrists or upper arms, Pentravan shows an 8 fold increase in absorption on average when applied to the scrotum.
Pentravan reaches peak plasma concentrations within 4 hours. Blood drawn 5 hours after it's application reflect its efficacy in raising total testosterone levels extremely quickly and efficiently.
Lastly, scrotal creams leave a silky smooth nutrient rich looking sheen on the boys...who would object to that? Applying cream to a pair of freshly shaven grapes can't be worse than using a thin hollow metal ice pick to puncture every layer of skin through the fascia and deep into the muscle to inject Testosterone...can it?
What is the other lipoderm matrix carrier compound you were considering using? You said it was a vanishing cream. What is the compound?