Telmisartan powder down the hatch?

[Tbaz192]

Alright yall, probably over thinking this.
Just picked up 100g of telm. Just needed bulk supply. More cost effective versus INT pharm.

So I have the mg scoopers and a .001g scale.
25-35mg scoopers are volume versus weight, so it takes a few to hit the weight of 0.080g
Which is 80mg.

Now do I have to capsule it up? Or can I just essentially dry shot it and wash it down with water?
Certainly not a scientist. Regardless it’ll be digesting/absorbing in my stomach still.

 

[HUGE McBIGLARGE]

I’d be interested in knowing this. I imagine you can just pop it in your mouth and swallow it. Tablets dissolve quickly anyway, so it’s not like they pass intact from the stomach.

Unless the orals are usually a capsule or an M&M in disguise like ibuprofen, my money is on it being fine.

But wait for someone who knows more to answer first.

 

[Tbaz192]

I’d be interested in knowing this. I imagine you can just pop it in your mouth and swallow it. Tablets dissolve quickly anyway, so it’s not like they pass intact from the stomach.

Unless the orals are usually a capsule or an M&M in disguise like ibuprofen, my money is on it being fine.

But wait for someone who knows more to answer first.

Yeah I read telm isn’t very water soluble. So in theory it shouldn’t breakdown till it hits your stomach.

 

[primojuju]

Throw it down, mix it with a drink, doesn't matter just get in you. I used to add my telmisartan, tadalafil, aromasin, and ezetimibe powder to my preworkout and they all worked just fine.

 

[HUGE McBIGLARGE]

Yeah I read telm isn’t very water soluble. So in theory it shouldn’t breakdown till it hits your stomach.

I would have thought whether it was water soluble or not would have nothing to do with when or how it chemically breaks down. Vitamin c is water soluble but it doesn’t break down in water.

As far as my peanut-sized brain is aware, the only reasons to have orals in capsules or tablets other than ease of dosing is for either delayed absorption, or to bypass the stomach (which I suppose is also delayed absorption technically).

 

[Ghoul]

It's not more cost effective than India pharma, and the big spike from a powder is a lot different than a timed oral release tablet that provides a more even dose all day. Also, Telm degrades quickly when exposed to air and moisture, the India pharma tabs are individually sealed in hermetic blister packs.

100g=1250 x 80mg doses. (if there's no waste)

100g=$110 @ QSC

1250 x 80mg tabs (Telvilite, Leeford Healthcare)= $65

 

[Tbaz192]

It's not more cost effective than India pharma, and the big spike from a powder is a lot different than a timed oral release tablet that provides a more even dose all day. Also, Telm degrades quickly when exposed to air and moisture, the India pharma tabs are individually sealed in hermetic blister packs.

100g=1250 x 80mg doses. (if there's no waste)

100g=$110 @ QSC

1250 x 80mg tabs (Telvilite, Leeford Healthcare)= $65

View attachment 302243View attachment 302244

Well shit.

Given the powder can give a big spike. How bad would that be?

 

[Tbaz192]

Was waiting for your reply ghoul.

You’re the major brains for us meatheads, appreciate you.

 

[Ghoul]

It's not terrible. Telm is an especially safe BP drug. I'm assuming you don't have a heart problem otherwise.

Do you know when your BP peaks? I'd take half the dose you're looking for, say 40mg, 30 mins before you expect highest BP of the day. Almost half of a tab is excreted, you're gonna absorb that powder much more easily.

On the other hand, you could cap it for a much more similar release to tabs...

99% of the time raws are way cheaper than even India pharma, but telm is an extremely cheap drug.

 

[HUGE McBIGLARGE]

Telm degrades quickly when exposed to air and moisture

I asked ChatGPT the following:
“Raw telmisartan powder is stored in a bottle which is opened daily and thus exposed to the air and moisture. How much degradation of the telmisartan is expected after a year (365 openings)?”

And it said 10-15% by the end of the year. Does that sound right?

 

[Ghoul]

I asked ChatGPT the following:
“Raw telmisartan powder is stored in a bottle which is opened daily and thus exposed to the air and moisture. How much degradation of the telmisartan is expected after a year (365 openings)?”

And it said 10-15% by the end of the year. Does that sound right?

I don't know, but my US pharma telm always comes in 3 sealed 30 tab bottles, each with a moisture absorber, and the pharmacist tells me they can't put them all in one bottle because the manufacturer says they must be limited to sealed bottles of 30 to protect them, so definately more sensitive than most drugs.

(one reason I like India pharma is everything is packaged in blister packs to protect every tab individually from light/air/moisture. The environmentalists would go nuts here, but it makes keeping a big supply on hand with minimal degradation easy.)

 

[deadbeef]

I don't know, but my US pharma telm always comes in 3 sealed 30 tab bottles, each with a moisture absorber, and the pharmacist tells me they can't put them all in one bottle because the manufacturer says they must be limited to sealed bottles of 30 to protect them, so definately more sensitive than most drugs.

I get a 90 day supply in one bottle.

1250 x 80mg tabs (Telvilite, Leeford Healthcare)= $65

Source?

 

[Ghoul]

I get a 90 day supply in one bottle.

Is that loose in a standard prescription bottle, or a manufacturer's bottle?

Source?

Happily, but first, out of curiosity, to buy or to fact check?

 

[DugPrime]

It's not more cost effective than India pharma, and the big spike from a powder is a lot different than a timed oral release tablet that provides a more even dose all day. Also, Telm degrades quickly when exposed to air and moisture, the India pharma tabs are individually sealed in hermetic blister packs.

100g=1250 x 80mg doses. (if there's no waste)

100g=$110 @ QSC

1250 x 80mg tabs (Telvilite, Leeford Healthcare)= $65

View attachment 302243View attachment 302244

This guy fucks

 

[Tbaz192]

It's not terrible. Telm is an especially safe BP drug. I'm assuming you don't have a heart problem otherwise.

Do you know when your BP peaks? I'd take half the dose you're looking for, say 40mg, 30 mins before you expect highest BP of the day. Almost half of a tab is excreted, you're gonna absorb that powder much more easily.

On the other hand, you could cap it for a much more similar release to tabs...

99% of the time raws are way cheaper than even India pharma, but telm is an extremely cheap drug.

Typically is peaking mid afternoon. Work/gym time.
So I’ll try afternoon / before bed split.

My BP isn’t terrible. These are no BP med numbers
-Highest on blast is like 155-160 with high caffeine days.
-TRT is around 130-135
But even over time higher BP is bad obviously.


definitely keeping the telm in a dark place. Moisture packs. And in a better container.

I do have caps. Just a major bitch to do versus just downing it

 

[deadbeef]

Is that loose in a standard prescription bottle, or a manufacturer's bottle?

Generic in a standard prescription bottle with a desiccant.

Happily, but first, out of curiosity, to buy or to fact check?

To have as a source.

 

[Ghoul]

Typically is peaking mid afternoon. Work/gym time.
So I’ll try afternoon / before bed split.

My BP isn’t terrible. These are no BP med numbers
-Highest on blast is like 155-160 with high caffeine days.
-TRT is around 130-135
But even over time higher BP is bad obviously.


definitely keeping the telm in a dark place. Moisture packs. And in a better container.

I do have caps. Just a major bitch to do versus just downing it

What's your diastolic (the lower number)? Because based on the most up to date standards from the major cardiology orgs, those are pretty bad warranting immediately treatment if you were working with a preventative cardiologist or a general practitioner who was on top of his shit.

 

[Ghoul]

Generic in a standard prescription bottle with a desiccant.


To have as a source.

Your pharmacy tech is lazy, and dispensing them incorrectly. Next time inquire when calling in refill "I think these are moisture sensitive and supposed to be dispensed in original bottles, will they be?" to gently remind them.



pricelist.cosmicpct.com

They have a continuous buy 4 get 1 strip deal going (same as 20% off). You have to specify that in the order. You could ask PCT24 if they'll match.

85¢ per strip of 10. (then -20%).

 

[Tbaz192]

What's your diastolic (the lower number)? Because based on the most up to date standards from the major cardiology orgs, those are pretty bad warranting immediately treatment if you were working with a preventative cardiologist or a general practitioner who was on top of his shit.

If I remember correctly, it never breaks 80-90. Could be completely wrong.
I’ll have to check later today.

my general practitioner. Who also gave me my TRT script is pretty old school. He’s usually just like you’re alright limit the blah blah.

I’m moving soon. So I’ll be finding a new one anyways.

 

[Ghoul]

If I remember correctly, it never breaks 80-90. Could be completely wrong.
I’ll have to check later today.

my general practitioner. Who also gave me my TRT script is pretty old school. He’s usually just like you’re alright limit the blah blah.

I’m moving soon. So I’ll be finding a new one anyways.

We have another great thread that covers all this with a model "step by step" chart for docs based on the latest standards that help guide treatment decisions, which meds to choose from etc.

I can tell you that anything from 120/70 to 129/79 is no longer "normal" but "elevated", because extended periods in that range are associated with long term health damage.

Also, guidance advises rather than maxing out one drug, like Telm, it's preferable to use minimum doses of two different class BP meds. Greater effectiveness, fewer sides.

Telm is available in a single tab combined with numerous other BP meds for this purpose.