Test e lab synthesis

[Rand]

I'm gonna go backwards from test e to dhea
Here's how test becomes test e:


Drop me some likes

 

[maleficarum]

considering the relative ease and availability of high purity test e raws, why go through this effort?

 

[Rand]

considering the relative ease and availability of high purity test e raws, why go through this effort?

Post count and likes.

I did this in 2014 just to test my knowledge gathering skills. Its been sitting in my computer folder alongside other drugs.

I never used it, cuz pharma didn't hire

If there's no demand the topic will naturally die off

The next post will be the sort of the keystone step imo.

Will post if the number of likes increases

 

[sushak]

Will post if the number of likes increases

Just post it stop being a drama queen

 

[H&M]

The Merck Index worth everything.

 

[mochul]

https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/testosterone-enantate#:~:text=The%20current%20synthesis%20method%20for,obtain%20Testosterone%20(Scheme%201).

Starting material is simple to make from dhea through oxidation

 

[Rand]

https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/testosterone-enantate#:~:text=The%20current%20synthesis%20method%20for,obtain%20Testosterone%20(Scheme%201).

Starting material is simple to make from dhea through oxidation

I thought the 4AD didn't need protective group at 3beta carbonyl, according to dale:



Page 1

 

[mochul]

You have two ketone.
sodium borohydride reduces both aldehyde and ketone. You have no aldehyde group in 4-ad. So you have to protect ketone on position 3

 

[BigNoOne]

Will post if the number of likes increases

I’ve seen this on another forum.

Lol, I’ll post it if enough people give @Rand here enough downlikes.

Your move @Rand

 

[Rand]

You have two ketone.
sodium borohydride reduces both aldehyde and ketone. You have no aldehyde group in 4-ad. So you have to protect ketone on position 3

Never tried it, i wouldn't know. The info i have, is old. Things change.

Must be nice to be able to be a roid chemist

Page 2

 

[mochul]

You know what aldehyde and ketone means?
Aldehyde is in general more reactive because of less steric hinderence. There is teo R groups attached to ketone while aldehyde has one R group and one hydrogen which is way smaller.
4-ad does not contain any aldehyde. You are mixing everything together

 

[Rand]

I’ve seen this on another forum.

Lol, I’ll post it if enough people give @Rand here enough downlikes.

Your move @Rand

You don't even care about the quality of your hplc results. No move.

 

[Rand]

You know what aldehyde and ketone means?
Aldehyde is in general more reactive because of less steric hinderence. There is teo R groups attached to ketone while aldehyde has one R group and one hydrogen which is way smaller.
4-ad does not contain any aldehyde. You are mixing everything together

That is true, but in this case the ketone involved is an enal. That's a conjugated bond.

So yes there is a difference.

We are not making test from simple acetone or aldehyde.

You have swiftly turned a cyclic compound into a linear planar one, just to get a emotional reaction.

 

[mochul]

You know what aldehyde and ketone means?
Aldehyde is in general more reactive because of less steric hinderence. There is teo R groups attached to ketone while aldehyde has one R group and one hydrogen which is way smaller.
4-ad does not contain any aldehyde. You are mixing everything together

You are reducing the ketone group at 17 position. Under same conditions, the ketone group will be reduced too. If i am not wrong, the ketone group at 3 position is less reactive because of stability from the double bond than the other ketone, but still reactive

 

[Rand]

You are reducing the ketone group at 17 position. Under same conditions, the ketone group will be reduced too. If i am not wrong, the ketone group at 3 position is less reactive because of stability from the double bond than the other ketone, but still reactive

Not me, Dale.
He reports good selectivity with the conditions he tried in his paper, which is why i brought up the protective group issue.

Is simply I didn't know it was needed.
If it's needed it's good to know


Page 3

 

[mochul]

Not me, Dale.
He reports good selectivity with the conditions he tried in his paper, which is why i brought up the protective group issue.

Is simply I didn't know it was needed.
If it's needed it's good to know
View attachment 303376

Page 3

Mate, the study compares aldehyde with ketone. Not ketone with ketone
I am understanding you wrong correct me