Primo more than likely did not lower your LDL. Something else did that, like your diet or being on the statin for a longer duration of time.
Lipid lowering drugs to not really increase HDL.
MESO-Rx
Anabolic Steroids
Update on statins
- Thread starter 120nmol
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Lipid lowering drugs to not really increase HDL.
BamaCrazy
Member
I’ve been taking 10mg Rosuvastatin for several years. My natty HDL has been in the 40’s since I discovered I had cholesterol issues in 2005. I’ve never been able to get it higher. But this drop into the 30’s is recent. On 11/13 it was 44. My diet has boringly remained unchanged. I’m going to increase cardio and see what impact that has.
OldGHGuy
Member
For me, Lipotor dramatically reduces both HDL and LDL but the ratio between the two remains constant.
readalot
Member
Trigs? Your trig/hdl-c ratio +/- statin?
Grey Spartan
Member
Same
Grey Spartan
Member
It raised my triglycerides.
OldGHGuy
Member
My trigs stay fairly constant in the low 90's. The trig/hdl ratio is also relatively unchanged on the statin, which for me stays between 2.5-2.8. I have low HDL which I have never been able to budge upward - this would greatly improve my ratio which I would like to do (>3 indicates high stroke/heart attack risk which I am too close to for comfort).
On "blast", my ratios stay the same, the raw numbers just increase.
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Eddie.
Member
It seems ezetimibe does that.
BamaCrazy
Member
That’s what this study seems to indicate.
“EZE increased HDL-sterol (25.5 ± 8.0%, p = 0.008) including intermediate (34 ± 14%, p = 0.02) and large (33 ± 16%, p = 0.06) HDL.”
Effect of ezetimibe on low- and high-density lipoprotein subclasses in sitosterolemia - PubMed
EZE improves VLDL and HDL subfraction distribution, thereby reducing the atherogenic lipid profile, thus providing potential clinical benefit in sitosterolemia beyond TC and PS reduction.
pubmed.ncbi.nlm.nih.gov
I have a shipment coming to test this out. But the downside is your risk level remains unchanged. “clinical trials haven't shown that increasing HDL cholesterol levels with medicines reduces the risk of heart attack.”
But it doesn’t hurt trying.
MA11
Member
First time a see a HDL range starting at 35.View attachment 306377
How would you say my cholesterol numbers are?
I would say good but better ask you experts
Bottom of the screenshot
I am no expert but my cardiologist said that lower than 55 LDL is what he wants to see.
Eddie.
Member
Where do you see it usually? In my lab starts from 35 too.
MA11
Member
I have bloodwork from two different labs.
One starts at 54 and the other at 45.
Unit is mg/dl
egruberman
Member
I’d like to know ApoB, typically because that gives an accurate count of atherogenic particles. LDL is calculated and the ratio of LDL to VLDL will influence the risk assessment.
Typically…. An LDL-C below 60mg/dL is exceptional for someone not on lipid lowering meds. He’ll, it’s great for those that are.
Maybe, but not in my experience
egruberman
Member
By my estimation, anyone folllowing the ACC guidelines for standards of care from 2022 is basing their treatment on outdated information.
Problem being that very few MDs are going to accept the liability of diverging from the standard of care.
The risk model we use, the fact that we calculate risk using LDL-C, the nearly complete aversion to prevention vs. treating a disease that is already present, these are outdated, and yet that’s how things are done in this country.
Ezetimibe is so good though
Ezetimibe Lowers Risk of Alzheimer's and Related Dementias over Sevenfold, Reducing Aggregation in Model Systems by Inhibiting 14-3-3G::Hexokinase Interaction - PubMed
Numerous factors predispose to progression of cognitive impairment to Alzheimer's disease and related dementias (ADRD), most notably age, <i>APOE</i>(ε4) alleles, traumatic brain injury, heart disease, hypertension, obesity/diabetes, and Down's syndrome. Protein aggregation is diagnostic for...
pubmed.ncbi.nlm.nih.gov
Ezetimibe and Cancer: Is There a Connection? - PMC
The high level of serum cholesterol caused by the excessive absorption of cholesterol can lead to hypercholesteremia, thus promoting the occurrence and development of cancer. Ezetimibe is a drug that reduces cholesterol absorption and has been ...
pmc.ncbi.nlm.nih.gov
I finally spoke directly to the cardiologist and I suggested keeping the statin dose low and adding Zetia as it seems to be the current way men's optimization places are tackling this. She said the ACC is flipped on this and they prefer to use as much statin as tolerated before Zetia bc she said there is more data on statins long term from a safety profile. She agreed that 108 LDL is still too high but said another month may cause it to continue lower. I also asked why she prescribed Lipitor instead of Crestor and she said she viewed them as interchangeable.
I watched a video with Tom O'Connor and I have gained a lot of respect for him. Early on I thought he wasn't on point but all of his recent content is great. He's nuked his LDL to "undetectable" using Crestor+Zetia+Bem Acid+Repatha. He had calcification in his 30s age and is 60 now after using AAS and TRT and or TRT+ for 35 years. Last I heard he's 120mg E4/5 days.
I've really come to believe that ASCVD is BY FAR the biggest risk w/AAS abuse and one doesn't know it until it's really too late and the calcification shows on a test.
egruberman
Member
This is my protocol as well. My LDL-C is 17mg/dL and my ApoB is 37mg/dL. My CAC is ~40 or so. There’s nothing conclusive that suggests that one can reverse atherosclerosis, but there is a little data showing that it can occur in the presence of very low ApoB.
Atorvastatin and Rosuvastatin are fundamentally not interchangeable. They have similar efficacy. Adverse side effects tend to manifest differently in either. One is lipophilic and the other is hydrophilic.
“Long term safety profile” my ass. Yes, it’s true we have data that shows that long term use of atorvastatin won’t kill you. It will give you type 2 diabetes in high enough doses, though, and as the dose scales up, it becomes less efficacious and yields greater adverse side effects.
Goddamn that makes me mad. Here’s the dose response curve showing how various statins flat line in efficacy well before the maximally tolerated dose:
If, for example you happen to look at the adverse side effects for bempedoic acid, you’ll find “tendon rupture” among them. Scary stuff. Then if you dive into the research you will find that this only occurs in the presence of high dose statins and can’t be teased apart from statin use.
In any case, I have a hard time with the statin conspiracy theorists, but I understand that they exist because of this bullshit.
The person I trust most among every other in this department is Allan Sniderman. Probably one of the world’s leading experts in lipidology. He’s described ASCVD as a disease of the endothelium. It progresses incrementally and irreversibly through life. The presence of calcified plaque represents a later stage of this disease. Peter Attia did a 2hr podcast with him a couple years ago that’s worth listening to.
I also tend to follow Tom Dayspring, who is an adherent of Dr. Sniderman and has a lot of pragmatic advice. He’s definitely more vocal and active in social media. See “dr. Lipids” on Twitter.
Any side effects for bodybuilder on the rosuvastatin and ezetimibe?
I have read statin can make you insulin resistance?
Any negative impact on muscles?
I need to gauge if it's worth for me to start taking both of maybe only ezetimibe as it seems the safer on the side effect profile
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