Why do some take DHEA and Pregnanolone on TRT?

[docpepper]

Notice some TRT protocols (and cycles for that matter) that have DHEA/Pregn stacked in there. I mean I get the basic premise that these are neurosteroids and theoretically shutting yourself down can have some effect on your production of them. But is there any clinical evidence to support supplementing them? Is it at all established that exogenous Test will hurt the production of these two?

I'm no expert, but it does seem like one of those "content" things that is being thrown around nowadays. The influencers that need to make daily videos so they make a video about how you "NEED" to be on this supplement, a low dose of this, a microdose of that, etc. But I really don't know. Anyone have some deeper insight on this question?

 

[J_Wayne]

There's a theory that high dose pregnenolone can prevent testicular atrophy.

https://lowtoxinforum.com/threads/pregnenolone-p5-fully-prevents-testicular-atrophy-due-to-steroid-ab-use-or-high-estrogen.31880/

 

[docpepper]

There's a theory that high dose pregnenolone can prevent testicular atrophy.

https://lowtoxinforum.com/threads/pregnenolone-p5-fully-prevents-testicular-atrophy-due-to-steroid-ab-use-or-high-estrogen.31880/

Thanks, I'm gonna check this out tomorrow and will give any thoughts I can.

 

[deadbeef]

This is why I've added pregnenolone:

 

[Country Club Hero]

I’m the same boat here. I have had bottles of pregnenolone and DHEA for years and used them intermittently hoping to find some holy grail level of TRT. Can’t say I notice much difference when taking them though.

I have read that they are important downstream hormones that trickle to a halt after supplementing with exogenous testosterone. Would love to know and understand it more.

 

[BamaCrazy]

I’m wondering if the two would increase my E2 some used in small amounts. Primo has E2 down to 12 on my last labs (8-35 pg/ml). I’m not feeling bad, but my emotions are a little on the colder side according to my Wife. Haha

 

[nullandvoid]

The way I've always understood it is because due to testicular atrophy, pregnenolone and DHEA production take a hit.. but both are produced elsewhere like the adrenals. I never got much out of supplementing either, and DHEA supplementation makes me irritable as hell, in spite of showing low DHEA on labs in the past. I have also gotten Pregnenolone checked a few times, and it has always shown within range. I do use hCG at 250iU three times a week.

 

[Eddie.]

The way I've always understood it is because due to testicular atrophy, pregnenolone and DHEA production take a hit.. but both are produced elsewhere like the adrenals. I never got much out of supplementing either, and DHEA supplementation makes me irritable as hell, in spite of showing low DHEA on labs in the past. I have also gotten Pregnenolone checked a few times, and it has always shown within range. I do use hCG at 250iU three times a week.

It's not necessary to supplement with DHEA and PREG if you use HCG. Personally i have no issues with DHEA, it was mid-low before i started gear and since then i'm taking 25mg every morning.

With pregnenolone though, it completely messes me up, it causes me depression, lack of motivation and anhedonia in just 2-3 days of taking it. Tried 10mg AM, PM, regular, micronized but hell no. It's unfortunate i can't test it in my country, maybe my levels are already high (doubt it though) and i can't tolerate it.