After five days, Spurlock gained 9.5 pounds (4.3 kg) (from 185.5 to about 195 pounds).
It was not long before he found himself experiencing depression, and he claimed that his bouts of it, along with lethargy and headaches, could be relieved by eating a McDonald's meal. His gastroenterologist, Dr. Lisa Ganjhu, described him as being "addicted".
On Day 21, Spurlock had heart palpitations and liver damage. His internist, Dr. Daryl Isaacs, advised him to stop what he was doing immediately to avoid any serious health problems.
He compared Spurlock with the protagonist played by Nicolas Cage in the movie Leaving Las Vegas, who intentionally drinks himself to death in a matter of weeks. Despite this warning Spurlock decided to continue the experiment.
On March 2nd, Spurlock reached day 30 and achieved his goal. In thirty days he "supersized" his meals nine times (five of which were in Texas, four in New York City).
His physicians were surprised at the degree of deterioration in Spurlock's health.
A 2006 study on fast food consumption by healthy individuals inspired by the documentary showed that, while the heavy diet does affect liver enzymes, it did not show the same dangerous effect shown in the documentary. This suggested that the extreme reaction must have had another cause,[28][29] and in 2017, Spurlock – who previously told his doctors he did not drink – admitted to copious amounts of alcohol consumption during the making of the film, which some critics, such as documentary filmmaker Phelim McAleer, have argued may better account for his liver issues and other health problems, since he had only changed his diet and not his alcohol intake during the experiment.[30]
en.wikipedia.org
To answer you question:
Even if they did go up from previously being at a normal level it's because of the alcohol. The claim that he got ED and lethargy from McDonald's in less than 30 days - sure fine. Whatever.
Severe mood swings and sudden depression and your liver getting fucked up to that degree (in 30 days!) - makes no sense.