2,4-DiNitroPhenol [DNP]

Heretic

New Member
Credit to the gods that wrote this... :)

HOW TO NOT FUCK UP DNP:

Since some guys have been playing around and disrespecting DNP and then griping to the forums about the painful results, we need to make this VERY specific and VERY correct so that people won't keep jumping for DNP out of curiosity, or without the willpower they need to operate this respondibly. So here are my experienced guidelines to using it the RIGHT way.

FIRST GUIDLINE: Dosing. Use ONLY 200mg a day for the first four days. I don't care that you don't "feel" anything yet and you wanna bump it up. DNP accumulates in the body, and not "feeling" something means NOTHING. It's there, and it's working (the effect on metabolism begins within two hours of the first dose!). Four days will let you test your tolerance: do you have an allergy? Does it give you a rash? etc.
Only after those four days do you bump it up, by 200mg a day. The average dose is 400-600/day, and more than that gets a little severe. A full gram is the highest dose I've heard anyone use. I've used that much, and it's hell. I like to stay around 600 a day, which is HOT but safe and effective. Take caps even hours apart through the day, ending about 4-5 PM.

SECOND GUIDLINE...How to eat on DNP. This is purely personal experience, because some guys like to carb-deplete *before* using DNP (then eat carbs as usual while on), and other guys like a low-carb approach throughout. Both are fine. Using DNP is the only time that fructose is a desireable cutting carb, because it keeps the liver replentished. That reduces lethargy and spares muscle.
Be aware that eating high-carb foods WILL increase the heat sensation within an hour, and last about 2 hours. That means don't eat carbs before bed unless you want those night sweats to be even WORSE.
Personally, I ate whatever the hell I wanted! IHOP, chinese, fajitas...Yes, I burned hot, but I still lost 1.5 pounds every 2 days. Keep protein HIGH for muscles' sake, and try it yourself.

Foods I suggest including:
Blueberry yogurt. Blueberries are excellent antioxidants, and yogurt cultures help with digestive function, gas, and stool consistency (disgustingly soft stools are common during DNP).
Oregano-based foods. Oregano is perhaps one of the most potent antioxidants around,a nd one spoonful counts as a vegetable serving. See this article
Pineapple - I've found that pineapple helps alleviate those "DNP Blues". The fructose helps, and pineapple enzymes aid in protein digestion.
V8 - one 12-ounce can supplies six servings of veggies, concentrated as an excellent source of antioxidants, lycopene, and recovery of electrolytes.
Oatmeal - high-fiber foods are necessary. You'll find out why around, oh, day 5 or so. Trust me.


THIRD GUIDELINE...Supplements and DNP. I suggest:
ECA - DNP is not a stimulant. To keep energy high and aid in fat loss, use an ECA. Some advisors suggest that regular ephedrine is preferable to norephedrine because of the more direct "hit" of energy.
Prohormones - perfectly fine on DNP. I used 1-AD just to help keep strength and muscle up, and it worked fine. No problems here. You won't GROW muscle on DNP, but it'll help with strength and protection.
Obvious stuff - multivitamin, ZMA, etc.
Biotest PowerDrive - No, I'm not pimping Biotest. But PowerDrive is an excellent pre-workout mixture that actually works. Plus it's low-carb (only 15 calories total), so it won't cause carb-heat in the middle of your workout.

Antioxidants - I'm giving my own personal list, and why I use them:
Alpha Lipoic Acid - aids in fat management and blood sugar, and an excellent antioxidant.
Grape seed extract
Syntrax Radox
Green Tea
Inositol - mood enhancement, antioxidant, and muscle support. 1 gram/3x day
Ellagic acid - protects cell DNA/RNA from damage by free radicals, and may even atack cancerous cells. 400mg/twice a day
Fruit antioxidants - beyond-a-century's powder of high-potency natural fruit anti's. 1 gram, 2-3x day.
Trimethylglyceine - antioxidant, helps move fat and blood lipids into the liver and out of the body. 500mg, 2x day.
Vitamins E and C

Supplements NOT to use:
Any medications that suppress energy. No allergy meds, antidepressants, muscle relaxers, or beta blockers. DNP will have you low as it is; don't worsen your body's energy by taking something that suppresses you further.

DRUGS - Sheesh, you'd think I wouldn't have to mention this, but two idiots in particular (right here on this forum) recently affirmed that some people still just don't get it. NO alcohol (not even "moderate"), NO ecstasy, NO GHB, etc. If you don't have the willpower to forego these habits, DNP is not for you.

Syntrax Swole - a personal discovery. I tried Swole while on DNP...once. Two hours of hell, feeling inside-out.

FOURTH GUIDELINE...working out on DNP. Keep lifting short, 30-40 minutes. DNP works very well, causing your body to use 150% or more the calories per action you'd normally use. That means DON'T try to repeat your usual workouts. Drop to moderate weights, 8-12 reps, not to failure, and with plenty of walking rest between sets. You are NOT going to grow muscle on DNP, so don't use your usual heavy routine. Since DNP can cause light-headedness and heat dizzyness, you have my permission to skip squats in favor of leg presses this time.

Cardio is a controversial one. My advice - do NOT do cardio on high doses of DNP (600mg or more). It's dangerous and counterproductive. Below that amount, some cardio is fine, but keep it to 20 minutes and not at full-gallop. Remember, DNP will drain water from your quickly, causing you to leech out minerals, vitamins, and salts. Don't overdo it.

During exercise, consume at least 1 liter of water per 30 minutes of work, whether you're thirsty or not. DNP is evil in the way it blunts thirst, while at the same time doing the cruel trick of bloating your body with water WHILE dehydrating you from water in your organs. MAKE yourself drink. Always folllow DNP exercise with antioxidants, carbs, and this is a good time to use your multivitamin.

Don't feel embarrassed about poor workouts. Just this morjning I did a workout with a whopping nine sets (wimp!) before calling it quits. Listen to your body, and let it tell you when enough's enough; don't guage workouts by what you *usually* can do otherwise.

Here's my research. This is AMAZING! Not only has not a single test found it to be carcinogenic, but test after tyest after test find that DNP actually ATTACKS cancer cells, and helps anti-cancer medications work better, and helps anti-leukemia medications work without destroying cell DNA, and suppresses tumor growth by 20-50%. The summaries are all right here, friends. Karma me up!

DNP is Ames negative, and does not promote tumors. See for yourself at http://toxnet.nlm.nih.gov/

http://www.epa.gov/ttn/atw/hlthef/dinitrop.html (2,4-Dinitrophenol | Technology Transfer Network Air Toxics Web site | US EPA) reports on health risks. While there have not been human studies, animal studies found no cancers caused by DNP administration. It is considered a toxin because it causes nausea, sweating, and weight loss.

Cyberiron.com reports on halth risks from external exposue. In other words, don?t get it in your eyes, or on your skin if you?re allergic. Pretty elementary stuff.

http://www.ebec2000.com/abstracts/056.htm This animal study documents a 64% increase in metabolism. "These findings confirm that DNP effectively increases metabolic rate..." Duh.

Biosource A PDF file about an antidote to DNP.

http://www.boehringer-ingelheim.es/...glesa/cap13.htm finds that DNP did not activate liver enzymes (MAT) associated with liver damage

"Comparative study of toxicity of 4-nitrophenol and 2,4-dinitrophenol in newborn and young rats." Koizumi M, Yamamoto Y, Ito Y, Takano M, Enami T, Kamata E, Hasegawa R. Division of Risk Assessment, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan. This study found that DNP can induce death in overdosed amounts, but that up to that point no toxicity was evident, nor were there any abnormalities in physical development.

"Phenol toxicity and conjugation in human colonic epithelial cells." Pedersen G, Brynskov J, Saermark T. Dept of Medical Gastroenterology, Herlev University Hospital, Copenhagen, Denmark.. This study found that DNP has a toxic effect on cells of the colon, with "toxic" defined in two ways: first, it interfered with metabolism (this we know?it?s the intended effect of DNP users!) and second, it interfered with bowel inflammation (not a health risk. This is caused by osmotic effect, with the worst results being softened stools and gas).

"Mechanisms of bacterial resistance to macrolide antibiotics." Nakajima Y. Division of Microbiology, Hokkaido College of Pharmacy, 7-1 Katsuraoka-cho, Otaru, Hokkaido 047-0264, Japan. This study found that antibiotic-resistant bacteria could be thwarted with DNP. "the extent of the accumulated drug in a resistant cell increases as much as that in a susceptible cell in the presence of an uncoupling agent such as?2,4-dinitrophenol (DNP)."

"Absence of Crabtree effect in human melanoma cells adapted to growth at low pH: reversal by respiratory inhibitors." Burd R, Wachsberger PR, Biaglow JE, Wahl ML, Lee I, Leeper DB. Departments of Radiation Oncology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA. Check this out?DNP actually helps make melanoma tumors easier to attack by increasing ratio of oxygen consumption to lactic acid production, while glycolysis remains the same. "Therefore, tumor acute acidification and oxygenation can be achieved by exposure?"


"New insights in the cellular processing of platinum antitumor compounds, using fluorophore-labeled platinum complexes and digital fluorescence microscopy."
Molenaar C, Teuben JM, Heetebrij RJ, Tanke HJ, Reedijk J. Department of Molecular Cell Biology, Leiden University Medical Centre, The Netherlands. DNP is used as a control in tests of antitumor cells because it does NOT bind to cell DNA, nor promote tumors, yet its staining abilities enable tracking of the uptake of antitumor drugs.

Specific inhibition of breast cancer cells by antisense poly-DNP-oligoribonucleotides and targeted apoptosis." Ru K, Taub ML, Wang JH. Department of Biochemistry, State University of New York, Buffalo 14260-3000, USA Are you ready for this? DNP actually INHIBITS (!!!) breast cancers! Yes, not only does it NOT promote cancers, it?s being recognized as a cancer-fighter/blocker. "Two membrane-permeable and RNase-resistant antisense poly-2'-O-(2,4-dinitrophenyl)-oligoribonucleotides (poly-DNP-RNAs) have been synthesized as inhibitors of human breast cancer?fluorescence assay indicates that the targeted antisense inhibition by poly-DNP-RNAs leads to apoptosis of SK-Br-3 cells but does not affect nontumorigenic MCF-10A cells. The control poly-DNP-RNAs with random or sense nucleotide sequence are completely inactive." Plain English? DNP can be synthesized as an anti-cancer compound, because tests show that it blocks mutagens but does NOT affect non-mutagenic (healthy) cells, and has no RNA effects on them.

"Heat shock protein induction by certain chemical stressors is correlated with their cytotoxicity, lipophilicity and protein-denaturing capacity." Neuhaus-Steinmetz U, Rensing L. Institute of Cell Biology, Biochemistry and Biotechnology, NW II University of Bremen, Germany. The thermic effect of DNP induces protein synthesis (heat shock protein, or HSP, synthesis). In fact, it?s quite GOOD at it: "ASA, DNP and CCCP induced HSP at lower concentrations than substances with a similar lipophilicity?"

"Comparative effects of the metabolic inhibitors 2,4-dinitrophenol and iodoacetate on mouse neuroblastoma cells in vitro." Andres MI, Repetto G, Sanz P, Repetto M.
National Institute of Toxicology, Seville, Spain. In this study, DNP?s observed effect was an increase in metabolism (duh!), while the other toxins compared to it had harmful in vitro effects but no increase in metabolism.

"Inhibition of uncoupled respiration in tumor cells. A possible role of mitochondrial Ca2+ efflux." Gabai VL.Medical Radiology Research Center, Russian Academy of Medical Sciences, Obninsk. DNP not only does not cause tumors, but it inhibited their respiration by 20-25% compared to controls.

"Amsacrine-induced lesions in DNA and their modulation by novobiocin and 2,4-dinitrophenol." Shibuya ML, Buddenbaum WE, Don AL, Utsumi H, Suciu D, Kosaka T, Elkind MM. Department of Radiology and Radiation Biology, Colorado State University, Fort Collins 80523. In this study, researchers found that DNP abrogates?or disrupts?cytotoxicity in hamsters (using cancerous cells). They expected to find that DNP would interfere with anticancer treatments, but instead found that DNP increased their effects. They state, though, that they cannot claim a proven effect of DNP on anticancer treatments yet, although they do agree that treatment with DNP actually enhanced the effects of the DNA regenerative therapy of anticancer chemotherapy.

"Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note." Kaufmann SH. Oncology Center, Johns Hopkins Hospital, Baltimore, Maryland 21205. The authors warn that certain anti-leukemia drugs resulted in "extensive DNA degradation." BUT (good ol? DNP to the rescue!), "Preincubation with dinitrophenol abolished the effect?"

"[Dependence of the nature of the action of metabolic inhibitors on ribosomal RNA synthesis in Ehrlich ascites carcinoma cells on cell integrity]" [Article in Russian] Akhlynina TV, Buzhurina IM, Panov MA, Rozovskaia IA, Chernaia NG. DNP actually inhibits the synthesis of RNA in carcinoma cells. In other words, it helps cancerous cells commit suicide by neutering themselves. "Ribosomal RNA (rRNA) synthesis in the intact Ehrlich ascite carcinoma cells is selectively inhibited by papaverin (ED50 = 0.01 mM), 2,4-dinitrophenol (DPN; ED50 = 5 microM), and actinomycin D (ED50 = 0.1 microgram/ml)."

"Autocatabolism of surface macromolecules shed by human melanoma cells." Bystryn JC, Perlstein J. Cancer Res 1982 Jun;42(6):2232-7. This study finds that DNP helps melanoma cells die (autocatabolize) while other cells are unaffected.

http://www.geocities.com/byggdegstor/dnpforside - tons of research, including medical studies. Excerpts:

DNP does not cause liver damage: "Their analyses demonstrate, beyond a doubt, that the liver does not suffer any damage in the course of dinitro treatment." (Biological Study of Dinitro Drugs in Humans By Dr. Jacques Bell. Bell, Jacques. 1939. Etude biologique des produits dinitres chez l'homme. Medecine. 19:749-54. Translation ? 1996 Robert Ames)

Also: "Experimental studies on animals do not show toxic effects of dinitrophenol on the kidney. Anatomical-pathological examinations of animals, even those which died from a massive dose of dinitrophenol, do not reveal any important anatomical changes, except a small degree of cytolysis. Clinical documents are not abundant, but, on the whole, do not seem to demonstrate that dinitrophenol is toxic for the kidneys."

"Dinitrophenol has almost no action on the blood cholesterol. (Grant and Schube)."

"it doesn't seem that dinitrophenol at usual clinical doses is likely to harm the kidneys."

"Dinitrophenol is remarkable for its absence of effect on the cardio-vascular system...dinitrophenol is absolutely devoid of toxicity for the heart."

"Dinitrophenol does not attack cell tissue albumin and does not determine the fat loss to the expense of the muscles, contrary to thyroxine."

"dinitrophenol offers this precious advantage that the cessation of its use at the slightest appearance of signs indicating an imminence of intoxication results immediately in the arrest of those symptoms." (Professor Pouchet)."


Interestingly, one medical theory on a health ADVANTAGE of DNP is that the slight increase in thermogenic temperature simulates the fever a body induces during a viral attack. The body increases itsheat to protect organs but kill viruses, and some theorize that DNP can do the same thing, thus killing viruses in the body. In this mechanism, DNP may have an immune-enhancing effect.
 
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Yea man... keep those multi-vitamins steady.

Anything high in anti-oxidants... I went to a produce wholesaler and bought a big box of blueberries... ate them often.

Have PLENTY of fruit and veggies.

I housed lots of berries and kiwis, some pineapple, lots of green apples. Throw in a misc fruit here and there, like a nectarine, or some plums, just for variety.

The cleaner the proteins the better... i ate some fish, chicken, and turkey, but my protein was mostly from shakes.

I kept my fish oils and fatty acids high (Omega 3-6-9, CLA+ALA+GLA, flaxseed oil...)

I did use 5HTP and Caffeine to help with the mood and energy. If you find a good clean ECA (and by clean I mean one that uses ephedrine and not ephedra) you should try that. And it'll help with the lethargy.

and drink PLENTY OF WATER. can't stress it enough... I would drop the gaterade though... I wouldn't use it... high in sodium... sugars.... yada yada yada... just do agua... water. Carry a comfy gallon jug with you ... and refill it as many times as you can. Don't be afraid of the water weight or water intoxication.... the DNP is sucking you dry... and when it's gone, the water flies right off. DRINK WATER! DRINK WATER! DRINK WATER!

:)


Hope this helps. Happy shredding.
 
As requested, please find attached an Excel worksheet that is a starter for monitoring dnp levels within the body based on dosing at any point throughout the day. To use:

(1) in the date column, put in the date and time when you are taking a cap of dnp
(2) in the corresponding dose column, put in the appropriate amount of dnp POWDER in the cap that you just ingested in step 1

(3) the spreadsheet should monitor / calculate your dnp level at any point in the future. To estimate at some point beyond your last dose, just input the date and time you wish information on, put the next dose at zero, and you should see the dnp level within your body at that time.

Note that this spreadsheet has not been filled out through eternity. I should do pretty well for tracking ~20 doses, after that, you will need to extend the spreadsheet to permit more inputs, AND you must continue to build the calculation cells out to the right. Simply follow the trend already in place and you should be fine. For any requesting assistance, let me know. Unfortunately, I had to shorten the workbook considerably to allow it to fit into meso's attachment regulations. by email I should be able to provide the entire file, and to check others files as necessary.

Hope this helps ... and remember, there is NO substitute for common sense. a model in the hands of someone who doesn't understand the model is DANGEROUS. please make sure you understand the calculations before relying fully upon the model for information.

Best regards,
just one of many neighborhood geeks

Would anyone happen to have this spreadsheet or know where to find it online?
 
has anyone run letrozole/adex during a dnp cycle? would taking letro at 2.5mg to suppress estrogen during a dnp cycle help with the fat burning process?

you sure can........and the anti-e will help you 'masculinize" so to speak the fat loss.........how do i explain it.....well if youre prone to collecting fat on your upper arms, ass and hips these will be the places where youll notice fat loss first
 
Hi guys,

I have read a lot of about DNP and also the 1st post of this topic is a great one.

I plan to do DNP in few days, and also write a blog about it for users like I currently am - to know hows the process of DNP changhing my physiscs. What I also prepared to do is to take photos of my body in the morning and evening, so I could prove some results.

Though I have few questions and maybe a confirmation of my plan for the next weeks.

Please take a look on this:

I am 22yrs old, great physics, no problems, my weight is about 92 kilogram, and am 189 cm tall, my target is about 84 kgs - we will see..

I am planning to do 210 mg / day for 10 days, than 10 days break, and another 10 days with 210 mg/day - never more. The 210 are splitted into 3 capsules with 70mg that I plan to take at 8am 2pm and 8pm.

Does this sound good? Shal I adjust anything? 210 is a bit low dose - from that I have read about 400-600 is OK, 200 sounds pretty low - dont want to go higher. I also do not plan to take any AAS or anything liek that.

And now couple of my questions:

FOOD - what is the BEST to do when on DNP? My target are best results, so if you tell me eat shit - I will, of course the limit is anything that should not be healthy... What to eat? When?

FOOD how about protein - milk mix? Is that good one? Pro- or contra-productive?

FOOD how about carbs food? High ? Low? When High why, when low why?

Workout - shall I workout? If so each day? Or each 2nd? If so, what? Cardio? Or some lifting? Running?

Pelase provide me answers to these questions, I will show you than at teh end my blog and my photos so you can decite weather it worked or not...

Thank you a lot

Peter
 
you sure can........and the anti-e will help you 'masculinize" so to speak the fat loss.........how do i explain it.....well if youre prone to collecting fat on your upper arms, ass and hips these will be the places where youll notice fat loss first

I took 20mg of Nolva on my last run, worked pretty good in conjunction with the DNP.
 
i am thinking of doing 0.5mg arimadex,20mg kessar daily,450mg dnp 5 days on 5 days off for 30 days.will see how it goes,i have about 22-30 pounds to drop so can see how it goes.

images
 
Just registered to pop in and say many thanks for this thread and to Conciliator for the information...

I've been sitting quite a lot of DNP for quite a while now, scared to death to try this shit, due to the sheer amount of 'bro-science' out there, til I started researching and subsequently, ran into this wonderful thread.

Been on a 6 month transformation (5 months in) to which I went from 200-ish to now around 165 lb's @ 12/13% body fat. Going to try and hit 10% before I run a mild DNP cycle. (I'm 5 foot 9)

Plan is to run a pretty mild cycle here in a few weeks, starting at 150mg a day for the first week to asses tolerance and maybe bump it up after. But I'm quite sensitive to anything I put in my body, so will probably just run a mild 3 week cycle, monitor myself closely and see where it goes.

I've had this DNP sitting in my cupboard for about two years now. Is there any sort of expiration on DNP or does it decrease in strength over time?

It's been sitting in a plastic baggy in a dark, dry part of my cupboard that really never sees the light of day and stays consistently the same temp year round. (stained the shit out of my cupboard actually)

Again, thanks for all the info!
 
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Just registered to pop in and say many thanks for this thread and to Conciliator for the information...

I've been sitting quite a lot of DNP for quite a while now, scared to death to try this shit, due to the sheer amount of 'bro-science' out there, til I started researching and subsequently, ran into this wonderful thread.

Been on a 6 month transformation (5 months in) to which I went from 200-ish to now around 165 lb's @ 12/13% body fat. Going to try and hit 10% before I run a mild DNP cycle. (I'm 5 foot 9)

Plan is to run a pretty mild cycle here in a few weeks, starting at 150mg a day for the first week to asses tolerance and maybe bump it up after. But I'm quite sensitive to anything I put in my body, so will probably just run a mild 3 week cycle, monitor myself closely and see where it goes.

I've had this DNP sitting in my cupboard for about two years now. Is there any sort of expiration on DNP or does it decrease in strength over time?

It's been sitting in a plastic baggy in a dark, dry part of my cupboard that really never sees the light of day and stays consistently the same temp year round. (stained the shit out of my cupboard actually)

Again, thanks for all the info!

It's good to see people still using this, I know you've had yours for a couple years, but it seems that it's been hard to obtain- especially with the bust that happened in Dec. Best of luck!
 
genxxl and couple other websites got royally fucked few months ago..not just dnp..they sold steroids too...

Ahhhhh, bummer... well, I'll have to make sure my DNP cycle counts then.

The more I re-read this thread, and read it again. Not sure I can wait a couple weeks now. Starring @ this DNP in my cupboard is driving me nuts and I wanna lose this last 5-10lb's, which should drop me into single digit bodyfat territory.

Might start running a low dose this weekend. I have 150mg caps, that are crystal, according to the guy I bought them from. Will probably just run those for 5-7 days and assess how I feel from there.

I hate giving up my workout routine, mainly because I just enjoy it... so I'm thinking I will probably stay @ a pretty low dose throughout, so I can maintain some level of enjoyment from my workouts, haha...

Will eat around 2-2.2k calories on a 40/30/30 macro split... so not much will change there. If/when I decide to run it, I'll keep a mini log and post up my thoughts about it all once I'm done.
 
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hi... i would appreciate any help.
I am 19. i am female have a height of 5 feet three inches and i weigh 10.5 stone. this is overweight acording to the BMI i cslculated. been struggling with my weight for ages, i just want to get back QUICKLY to my size 8 dress size.. im currently a size 12. basically i want to be 8 stone so i feel healthier and more motivated to keep a healthy lifestlye and maintain this weight.

once i achieve this weight i will feel better about myself and i wont return to use these substances.

i am a medical student so maybe i am being overly cautious but i was thinking to try taking a 50mg dose of DNP and i was wondering what i can expect to feel/how much i would lose in a week if i just took mg at the start of the week..

never taken any drugs/substances before so am really really apprehensive about this.. but im just desperate to lose this weight!

would really appreciate any help/guidance.
 
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bought 25grs pure powder, is not in my hands yet, but how do I
to administer it?
I need to put it is encapsulated? being necessary, someone could
suggest links and tips on how to put it inside a capsule and
equipment needed?
Or mix in an amount to drink and swallow?
 
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