Nighttime (pre-bed) dosing should be viewed as the default case for rhGH administration (it's how I use it almost exclusively). Aside from the use of rhGH for: i) lipolysis, ii) muscle anabolism, and iii) accelerating musculoskeletal soft tissue healing [all have individual considerations and different approaches, i.e., protocols], the use nighttime rhGH is optimal.
The tradeoff to nighttime dosing with respect to lipolysis is simply that you cannot preferentially use fatty acids for fuel/β-oxidation as you can do so acutely by this protocol. But, nighttime administration is particularly anticatabolic, solves for many the lethargy effects and hyperglycemic effects (can't eat while you're asleep), and still promotes essentially all of the GH benefits to exercise, recovery, sleep, etc.