MESO-Rx
Anabolic Steroids
I'm glad you find this thread helpful and of benefit. It's not something that I intended to encourage rhGH use but I suppose if you're pissing away money on secretagogues that cannot accomplish your goal(s) then it's good to see.
That’s how big a waste you consider secretagogues? Edit - for whatever it’s worth I’m have great results with ipa/mod grf. I’m pondering the safety of that compared to hgh and it’s appearing more to me like hgh may be the safer alternative. I’m worried about blood glucose and insulin sensitivity tho. I guess when your book comes out I’ll have a solid protocol to protect myself as much as possible from these things.
I believe that secretagogues are wasteful when they cannot be used to accomplish what rhGH can or where their financial expense is greater than rhGH for the same outcome.
Interesting. Am I reading you correctly, you believe GHRPs cause insulin resistance? Or are you saying that’s the trade off (increased cortisol & prolactin with ghrp vs insulin resistance with GH)?
GHRPs cause greater insulin resistance than rhGH with respect to efficacy vs. tolerability, and increase cortisol & prolactin which rhGH does not.
This is friggin’ interesting. All my research lead me to believe that the GHRP (especially ipamorelin) would have less impact on insulin resistance, tho I did read GHRH (like mod grf 1-29) could have an impact on insulin. I will get a blood glucose tester and check myself regularly now (ngl that concerns me). I have had very good effects from my 3
The Mod GRF (1-29) & Ipamorelin combination is OK, better than just Ibutamoren (MK-0677) for insulin resistance. Its relative unfavorability vs. rhGH relates mostly to financial expense & injection frequency, and an upper limit of about ~ 2.5 maybe 3 IU/d GH.
Have you seen Mod-GRF & Ipamorelin combo or Mod-GRF/GHRP-2(or 6) combos actually have an effect on blood glucose? I understand MK being a completely different story, I'm just now really curious because I've been playing with both ghrh/ghrp peptides (specifically mod-grf and ipa or ghrp-2/6) and rhGH, and then both together, and I've been measuring blood glucose regularly trying to understand what's doing what.
I tried something similar with peptides after workout and at night with Gh.
That's probably the long and the short of it. Being a pin cushion gets old quick. Thanks for your input bro.
I believe either in this thread or in the thread about what can diminish the impact of rhGH Type-IIX has discussed how adding in GHRH/GHRP to a rhGH cycle actually reduces the effects of rhGH due to a negative feedback. I can’t remember the particulars atm but I’ll try and dig up the post.
Awesome, thank you, I will give this a thorough read.
Wait...so I've been basically starving myself (overexaggeration) after my GH administration out of fear of insulin resistance for no reasonable benefit? Correct me if I'm wrong.
Right! Its really difficult to get all that old way of thinking out of our heads. I catch myself thinking ~'no food, just dosed hgh'. It's like we gotta rewire our brains to stop what has been repeatedly pounded into our liitle minds.
diabetesjournals.org
This 1966 study that you posted argues against the existence of IGF-I, which we now know to be ridiculous.This is pre-Somatomedin Hypothesis (that has since been superseded by the Dual Effector Theory) research.According to this study, from my understanding, elevated insulin around the same time as GH completely blunts the free fatty acid release. Even with exogenous administration.
But instead, amino acids, insulin and HGH have a synergistic anabolic response. So less fat burn, more protein synthesis.
I’m not the greatest at breaking down these research papers but that what I’m getting from it.
“The fat mobilizing effect of HGH are inhibited by concentrations of insulin similar
To those obtaining in the post-prandial period”
Growth Hormone-Insulin Interaction Fact and Speculation
The metabolic effects of human growth hormone may be segregated into two classes which can be termed “insulinlike” (or “anabolic”) and “contra-insulin” (or
If there were absolutely no effect of feeding on lipolysis, the protocol wouldn't refer to timing of meal ingestion. Still, you do not have to fast around a bolus and you should always eat breakfast. The efficacy of rhGH does not depend on obsessing to the point of skipping meals or starvation.
I see bloodwork that's all over the place with respect to blood glucose. Factors involved include dietary regimens (e.g., keto), exercise (muscular contraction increases GLUT-4 activity), body fat, dose, and other drugs.
There is an interference effect between rhGH & secretagogues. GH partially negatively feeds back on its own secretion.
Very curious what your protocol for mitigating insulin issues with rhGH as you seem just so knowledgeable about all the various processes exogenous rhGH kicks off.
I know this thread is directed at timing and fat loss, and I'm sure you already answered this earlier in the the thread but, you're saying there's no concern of effects on insulin sensitivity? Meaning one could dose upon waking and eat shortly after? I just want to make sure I'm tracking and not misconstruing your words.
what I took from the author, and I'm in no way attempting to speak for him, but rather to restate what I think was said in attempt to test my own understanding:
