Discussion in 'Steroid Forum' started by Todd1234, Oct 11, 2011.

  1. paula109

    paula109 Junior Member

    This I was looking for,thanks[​IMG]
  2. Tonyt03

    Tonyt03 Junior Member

  3. Michael Scally MD

    Michael Scally MD Doctor of Medicine

    Kang D, Shi B, Erfe MC, Craft N, Li H. Vitamin B12 modulates the transcriptome of the skin microbiota in acne pathogenesis. Science Translational Medicine. 2015;7(293):293ra103-293ra103.

    Various diseases have been linked to the human microbiota, but the underlying molecular mechanisms of the microbiota in disease pathogenesis are often poorly understood.

    Using acne as a disease model, we aimed to understand the molecular response of the skin microbiota to host metabolite signaling in disease pathogenesis. Metatranscriptomic analysis revealed that the transcriptional profiles of the skin microbiota separated acne patients from healthy individuals.

    The vitamin B12 biosynthesis pathway in the skin bacterium Propionibacterium acnes was significantly down-regulated in acne patients. We hypothesized that host vitamin B12 modulates the activities of the skin microbiota and contributes to acne pathogenesis. To test this hypothesis, we analyzed the skin microbiota in healthy subjects supplemented with vitamin B12.

    We found that the supplementation repressed the expression of vitamin B12 biosynthesis genes in P. acnes and altered the transcriptome of the skin microbiota. One of the 10 subjects studied developed acne 1 week after vitamin B12 supplementation.

    To further understand the molecular mechanism, we revealed that vitamin B12 supplementation in P. acnes cultures promoted the production of porphyrins, which have been shown to induce inflammation in acne.

    Our findings suggest a new bacterial pathogenesis pathway in acne and provide one molecular explanation for the long-standing clinical observation that vitamin B12 supplementation leads to acne development in a subset of individuals.

    Our study discovered that vitamin B12, an essential nutrient in humans, modulates the transcriptional activities of skin bacteria, and provided evidence that metabolite-mediated interactions between the host and the skin microbiota play essential roles in disease development.
  4. Fred88

    Fred88 Member

    the only 1 real working active substance against acne is
    It has really strong and mentally occurig side effects.
    Especially in the U.S. there are reviews about suicide do to this medicine.
  5. TheSpectre

    TheSpectre Member

    It still comes back after a few years, especially with juice. Plus, if you carry staph in your nose it's never going away without Bactroban on hand.
  6. Fred88

    Fred88 Member

    yes often it comes back, but for month or mostly years its gone as first.
    the psychical side effects of a really strong acne are hard.
    most people hide with strong acne.
  7. Michael Scally MD

    Michael Scally MD Doctor of Medicine

    Melnik BC. Linking diet to acne metabolomics, inflammation, and comedogenesis: an update. Clin Cosmet Investig Dermatol. 2015;8:371-88.

    Acne vulgaris, an epidemic inflammatory skin disease of adolescence, is closely related to Western diet.

    Three major food classes that promote acne are:
    1) hyperglycemic carbohydrates,
    2) milk and dairy products,
    3) saturated fats including trans-fats and deficient omega-3 polyunsaturated fatty acids (PUFAs).

    Diet-induced insulin/insulin-like growth factor (igf-1)-signaling is superimposed on elevated IGF-1 levels during puberty, thereby unmasking the impact of aberrant nutrigenomics on sebaceous gland homeostasis.

    Western diet provides abundant branched-chain amino acids (BCAAs), glutamine, and palmitic acid. Insulin and IGF-1 suppress the activity of the metabolic transcription factor forkhead box O1 (FoxO1). Insulin, IGF-1, BCAAs, glutamine, and palmitate activate the nutrient-sensitive kinase mechanistic target of rapamycin complex 1 (mTORC1), the key regulator of anabolism and lipogenesis.

    FoxO1 is a negative coregulator of androgen receptor, peroxisome proliferator-activated receptor-gamma (PPARgamma), liver X receptor-alpha, and sterol response element binding protein-1c (SREBP-1c), crucial transcription factors of sebaceous lipogenesis. mTORC1 stimulates the expression of PPARgamma and SREBP-1c, promoting sebum production. SREBP-1c upregulates stearoyl-CoA- and Delta6-desaturase, enhancing the proportion of monounsaturated fatty acids in sebum triglycerides.

    Diet-mediated aberrations in sebum quantity (hyperseborrhea) and composition (dysseborrhea) promote Propionibacterium acnes overgrowth and biofilm formation with overexpression of the virulence factor triglyceride lipase increasing follicular levels of free palmitate and oleate.

    Free palmitate functions as a "danger signal," stimulating toll-like receptor-2-mediated inflammasome activation with interleukin-1beta release, Th17 differentiation, and interleukin-17-mediated keratinocyte proliferation. Oleate stimulates P. acnes adhesion, keratinocyte proliferation, and comedogenesis via interleukin-1alpha release.

    Thus, diet-induced metabolomic alterations promote the visible sebofollicular inflammasomopathy acne vulgaris. Nutrition therapy of acne has to increase FoxO1 and to attenuate mTORC1/SREBP-1c signaling.

    Patients should balance total calorie uptake and restrict refined carbohydrates, milk, dairy protein supplements, saturated fats, and trans-fats. A paleolithic-like diet enriched in vegetables and fish is recommended.

    Plant-derived mTORC1 inhibitors and omega-3-PUFAs are promising dietary supplements supporting nutrition therapy of acne vulgaris.
  8. WorkOutGuy100

    WorkOutGuy100 Junior Member

    Get some accutane from MJR, I'm taking it and I HAD severe acne and it totally cleared up.
  9. WorkOutGuy100

    WorkOutGuy100 Junior Member

    Just make sure check your liver enzymes because accutane is no joke.
  10. ProV1

    ProV1 Member

    Is my bacne gonna go away?

    Guys, I was about 7 weeks into 700 mg per week test e and humming along nicely, great feeling, gains, libido and very little acne. Decided to give mast e a try for final 5 weeks and on first inj by following day was a little bumpy on shoulders, 2nd inj 3 days later and full on bacne and on chest almost overnight so immediately ended that experiment, finished my 12 weeks test cycle over a week ago and transitioned to TRT cruise of 200 per week but back is still a mess!! Thoughts on prognosis would be appreciated!! Little old for this lol..
  11. ProV1

    ProV1 Member

    Bump..pretty sure it's dht related, any ideas how long it's likely to linger and is my TRT dose gonna prevent recovery?
    Ozzy619 likes this.
  12. ProV1

    ProV1 Member

    Sorry for the multiple posts boys. Found what I was looking for!
  13. WorkOutGuy100

    WorkOutGuy100 Junior Member

    Accutane will cure you. Start with 20mg and work your way up. Take for about 6 months and you should be cured for a long while
    ProV1 likes this.
  14. Ozzy619

    Ozzy619 Member

    Sorry I just seen this. I believe there is a direct correlation between dht and acne. Acne is greatly increased with androgens. There was an article I posted a few days explaining it. So what did you find out?
    ProV1 likes this.
  15. rocketbunny

    rocketbunny Member

    Where can you get accutane?
  16. WorkOutGuy100

    WorkOutGuy100 Junior Member

    I've hear researchstop has some good stuff. But just get it from the same place you get pharm grade serms
    ProV1 likes this.
  17. rocketbunny

    rocketbunny Member

    No worries thanks mate
  18. ProV1

    ProV1 Member

    Thanks guys! Meso is awesome. My initial research didn't bring up a lot but after some digging I was able to find a wealth of info on here that let me know what I dealing with, why and how to treat if needed. Acne popped up almost immediately after first and second inject of mast e so I stopped right away and fingers crossed but I've had some improvement lately, so hopefully it will continue to get better even with my TRT doseage. This shit is like nothing I've ever experienced. Accutane is out there too if you look a little. Probably go with good ole Pharmacist if I end up having to.
  19. Michael Scally MD

    Michael Scally MD Doctor of Medicine


    Severe Acne Conglobata Induced By Anabolic-Androgenic Steroids

    The patient at the time of his ideal body image; the 21-year-old bodybuilder had a history of anabolic-androgenic steroid abuse (A). Severe acne conglobata (B); lesions include papules, pustules, abscesses, and deep ulcerations. Patient after 6 weeks of antiseptic-antibiotic therapy (C).

    Gerber PA, Kukova G, Meller S, Neumann NJ, Homey B. The dire consequences of doping. The Lancet. 2015;372(9639):656.

    Various cases in professional sports have brought the matter of doping—the use of performance-enhancing drugs—to the attention of the broad public.

    Here, we present a case of doping in a 21-year-old amateur bodybuilder. The man presented to our clinic feeling generally unwell.

    He was subfebrile and had massive, deep ulcerations, abscesses, and pustules located on his chest and upper back (figure).

    Persistent questioning revealed a history of continuous abuse of anabolic-androgenic steroids (testosterone enantate 250 mg plus metandienona 30 mg twice weekly), which was consistent with the diagnosis of a severe acne conglobata that was anabolic-androgenic steroid induced.

    Additional investigations showed a substantial impairment in sperm concentration and reduced testicular volume.

    Skin lesions showed rapid improvement after discontinuation of anabolic-androgenic steroid abuse and with antiseptic and antibiotic therapy. However, the extensive scarring is likely to remain with the young man for the rest of his life.
    ProV1 likes this.
  20. bornSkinny

    bornSkinny Member

    This option seems much cheaper than getting the generics which are also out there pharm grade. Anyone have actual experience with this? Seems kinda too good to be true