m_ob
New Member
Androgen receptor down regulation has been generally disproven, rather upregulation, but there is a lot of research that points to the ability of the androgen receptor to become desensitive or basically almost useless when exposed to high doses of androgens over time. Here's a reading on it, I'd like to know if anyone buys into this and what they do about it.
Basically, one must view the receptor sites as parking spaces.
Envision a slew of parking spaces that are all empty. Now we are going to call these parking spaces your receptor
sites and we shall call steroids the cars. Now I want you to imagine one of those old 1950's style drive up
hamburger stands where the girls come up in roller skates and take your order. Typically one would order a burger,
fries and a coke--ah the food of the gods--the waitress would take the order, go bring the information to the
cook, who would in-turn make the food and the waitress would then bring the food to you and you would then
begin eating which is the whole reason you came to the hamburger stand in the first place.
I think everyone can easily understand that. Which means everyone can easily understand all they need to know
about the receptor sites because they do the exact same thing. We will keep with this hamburger stand model and
explain what happens when you inject steroids and they begin to go to work.
Remember how I said steroids were like the cars and the parking spaces were like the receptor sites? Well it is
basically that simple. When you inject testosterone or any one of it's anabolic or androgenic derivatives, you are
sending a whole slew of "cars" into your system. Now these "cars" are on a mission--just like you would be if you
were hungry and heading to a hamburger stand. They have orders to place with the cells, but before they can
place them they must first find a parking space.
Now let's say you have never used steroids before. If this were the case, it would be very much like a hamburger
stand that was having a grand opening....lots and lots of empty parking spaces waiting for cars to fill them up and
place their orders. The steroids (cars) enter the system and come to a brand new hamburger stand called your
cells. Now these cells have never previously been open to the boat-load of anabolics that are now present in the
system because they previously only dealt with what your body naturally produced. However, there are lots of
extra parking spaces that can be utilized and so the steroids park themselves into these spaces.
Once they are parked a "waitress" called CYCLICl AMP literally crosses the cellular membrane which is totally
impenetrably to anything else and takes the order from the steroid. The order is quite simple: Build More Muscle!!
The "waitress" then crosses back through the cellular membrane and brings the order to the "cook" called the
Nucleus who begins to fill it by ordering its helpers called Ribosomes to produce muscle protein.. Now different
steroids will have slightly different orders in that some may have a bigger order for the cook to fill--such as
testosterone. The thing you have to realize is that a lot of times, after the order is placed, the steroid does not
necessarily leave the parking space and make it available to other steroids.....it will often sit in the parking space
even though it is no longer sending orders to the "waitress" to bring to the "cook", and this is where the problem of
"DOWN-REGULATION" comes in. You see even if you send in more and more fresh new "cars" to occupy the
receptor spaces, if they are already taken up by old "dead cars" you are **** out of luck.....
This is why you do not continually grow by injecting bigger and bigger doses of steroids. THERE ARE A LIMITED
NUMBER OF PARKING SPACES. Now it would not be so bad if all the parking spaces were taken by "cars" that were
sending orders to the cook, because that is when you grow. The problem is when there are "cars" that are no
longer sending orders and on top of that have dead batteries which is preventing them from exiting the receptors
parking space.
This is what the whole point of this article is....TOWING AWAY ALL THE DEAD "CARS" FROM THE RECEPTOR SITES
PARKING SPACES AS TO FREE THEM UP FOR NEW, FRESH, HUNGRY "CARS" TO OCCUPY THEM...This will result in
new muscle mass!
O.K. Trevor, I am with you so far, but what the **** can I do about it?
The answer is ...PLENTY!
First and foremost, is to plan sensible courses. This is why I am an advocate of short courses designed in such a
fashion as to have all drugs out of the system by the end of the cycle and then allow for a 3-4 week off time in
which you are totally clean. If you stay on these monster 4-6 month courses, you just wind up screwing yourself
and requiring that much longer of an off period. The longer you are on, the more the body recognizes that there is
"too much" in the system and will begin to take counter measures. And the longer you are on, the more "dead cars"
you will have sitting in the receptor parking spaces which means NO MORE GROWING!
Now with this in mind, how can we help get the cars out of there?
Well WE actually cannot, but the body can and will. Basically as time goes by, the body will free up the parking
spaces just like a tow truck would remove a dead car from a parking space. However, you are at the mercy of time
in this situation which is why it is important to utilize short courses that will cause less disturbance in the system,
less "dead cars" in the receptor spaces and therefore less time needed for the body to remove them and free up
the spaces.
Basically, one must view the receptor sites as parking spaces.
Envision a slew of parking spaces that are all empty. Now we are going to call these parking spaces your receptor
sites and we shall call steroids the cars. Now I want you to imagine one of those old 1950's style drive up
hamburger stands where the girls come up in roller skates and take your order. Typically one would order a burger,
fries and a coke--ah the food of the gods--the waitress would take the order, go bring the information to the
cook, who would in-turn make the food and the waitress would then bring the food to you and you would then
begin eating which is the whole reason you came to the hamburger stand in the first place.
I think everyone can easily understand that. Which means everyone can easily understand all they need to know
about the receptor sites because they do the exact same thing. We will keep with this hamburger stand model and
explain what happens when you inject steroids and they begin to go to work.
Remember how I said steroids were like the cars and the parking spaces were like the receptor sites? Well it is
basically that simple. When you inject testosterone or any one of it's anabolic or androgenic derivatives, you are
sending a whole slew of "cars" into your system. Now these "cars" are on a mission--just like you would be if you
were hungry and heading to a hamburger stand. They have orders to place with the cells, but before they can
place them they must first find a parking space.
Now let's say you have never used steroids before. If this were the case, it would be very much like a hamburger
stand that was having a grand opening....lots and lots of empty parking spaces waiting for cars to fill them up and
place their orders. The steroids (cars) enter the system and come to a brand new hamburger stand called your
cells. Now these cells have never previously been open to the boat-load of anabolics that are now present in the
system because they previously only dealt with what your body naturally produced. However, there are lots of
extra parking spaces that can be utilized and so the steroids park themselves into these spaces.
Once they are parked a "waitress" called CYCLICl AMP literally crosses the cellular membrane which is totally
impenetrably to anything else and takes the order from the steroid. The order is quite simple: Build More Muscle!!
The "waitress" then crosses back through the cellular membrane and brings the order to the "cook" called the
Nucleus who begins to fill it by ordering its helpers called Ribosomes to produce muscle protein.. Now different
steroids will have slightly different orders in that some may have a bigger order for the cook to fill--such as
testosterone. The thing you have to realize is that a lot of times, after the order is placed, the steroid does not
necessarily leave the parking space and make it available to other steroids.....it will often sit in the parking space
even though it is no longer sending orders to the "waitress" to bring to the "cook", and this is where the problem of
"DOWN-REGULATION" comes in. You see even if you send in more and more fresh new "cars" to occupy the
receptor spaces, if they are already taken up by old "dead cars" you are **** out of luck.....
This is why you do not continually grow by injecting bigger and bigger doses of steroids. THERE ARE A LIMITED
NUMBER OF PARKING SPACES. Now it would not be so bad if all the parking spaces were taken by "cars" that were
sending orders to the cook, because that is when you grow. The problem is when there are "cars" that are no
longer sending orders and on top of that have dead batteries which is preventing them from exiting the receptors
parking space.
This is what the whole point of this article is....TOWING AWAY ALL THE DEAD "CARS" FROM THE RECEPTOR SITES
PARKING SPACES AS TO FREE THEM UP FOR NEW, FRESH, HUNGRY "CARS" TO OCCUPY THEM...This will result in
new muscle mass!
O.K. Trevor, I am with you so far, but what the **** can I do about it?
The answer is ...PLENTY!
First and foremost, is to plan sensible courses. This is why I am an advocate of short courses designed in such a
fashion as to have all drugs out of the system by the end of the cycle and then allow for a 3-4 week off time in
which you are totally clean. If you stay on these monster 4-6 month courses, you just wind up screwing yourself
and requiring that much longer of an off period. The longer you are on, the more the body recognizes that there is
"too much" in the system and will begin to take counter measures. And the longer you are on, the more "dead cars"
you will have sitting in the receptor parking spaces which means NO MORE GROWING!
Now with this in mind, how can we help get the cars out of there?
Well WE actually cannot, but the body can and will. Basically as time goes by, the body will free up the parking
spaces just like a tow truck would remove a dead car from a parking space. However, you are at the mercy of time
in this situation which is why it is important to utilize short courses that will cause less disturbance in the system,
less "dead cars" in the receptor spaces and therefore less time needed for the body to remove them and free up
the spaces.
