Reversible hypogonadism and azoospermia as a result of anabolic-androgenic steroid use in a bodybuilder with personality disorder: a case report.
Abstract:
We report a case of reversible hypogonadism and azoospermia resulting from anabolic-androgenic steroid abuse in a body-builder with primary personality disorder. A keen body builder, a 20-year-old man, developed acute aggressive and destructive behavior after 10-month use of Bionabol (mean total dose of 1,120 mg per month), and Retabolil (mean total dose of 150 mg per month). He was found to meet the Diagnostic and Statistical Manual of Mental Disorders-IV ed. (DSM-IV) criteria for Borderline personality disorder. On admission to the hospital the clinical profile of the patient showed extremely low levels of serum testosterone. Values increased to normal levels 10 months after withdrawal of steroids. The semen was azoospermic at the beginning of the study period, oligospermic five months later, and reached 20 x 10(6) sperm per mL ten months after the steroid discontinuation. Anabolic steroids can greatly affect the male pituitary-gonadal axis. A hypogonadal state, characterized by decreased serum testosterone and impaired spermatogenesis, was induced in the patient. This condition was reversible after the steroid withdrawal, but the process took more than ten months. His personal imbalance could be considered a personality trait rather than a result of the anabolic-androgenic steroid use. There were probably dispositional personality characteristics that contributed to anabolic steroid abuse in our patient. The hypogonadal changes which occurred after his long-term steroid abuse were for the most part reversible.
Journal of Sports Medicine & Physical Fitness (J SPORTS MED PHYS FITNESS), 2000 Sep; 40 (3): 271-4. (32 ref)
Persistent primary hypogonadism associated with anabolic steroid abuse.
Fertility And Sterility [Fertil Steril] 2011 Jul; Vol. 96 (1), pp. e7-8. Date of Electronic Publication: 2011 May 14.
Abstract:
Objective: To report a case of primary gonadal failure due to the chronic abuse of anabolic steroids used for bodybuilding.
Design: Case report.
Setting: Department of Diabetes and Endocrinology, Morriston Hospital, Swansea, Wales, United Kingdom.
Patient(s): A 40-year-old man.
Intervention(s): None.
Main Outcome Measure(s): Clinical symptoms, levels of serum T, FSH, and LH.
Result(s): Primary gonadal failure resulting from anabolic steroid use.
Conclusion(s): We describe a case of initially secondary gonadal failure resulting from anabolic steroid use with subsequent primary gonadal failure and infertility. This case adds to the current literature and illustrates that the side effects of anabolic steroids can be prolonged and irreversible.
(Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.)
Substance Nomenclature:
0 (Anabolic Agents)
0 (Steroids)
3XMK78S47O (Testosterone)
6PG9VR430D (Nandrolone)
9002-72-6 (Growth Hormone)
DOI:
10.1016/j.fertnstert.2011.04.029
Anabolic steroid-induced hypogonadism--towards a unified hypothesis of anabolic steroid action.
Source: Medical Hypotheses [Med Hypotheses] 2009 Jun; Vol. 72 (6), pp. 723-8. Date of Electronic Publication: 2009 Feb 23.
Authors: Tan RS; HPT/Axis Inc., 1660 Beaconshire Road, Houston, TX 77077, USA.
Scally MC
Abstract:
Anabolic steroid-induced hypogonadism (ASIH) is the functional incompetence of the testes with subnormal or impaired production of testosterone and/or spermatozoa due to administration of androgens or anabolic steroids. Anabolic-androgenic steroid (AAS), both prescription and nonprescription, use is a cause of ASIH. Current AAS use includes prescribing for wasting associated conditions. Nonprescription AAS use is also believed to lead to AAS dependency or addiction. Together these two uses account for more than four million males taking AAS in one form or another for a limited duration. While both of these uses deal with the effects of AAS administration they do not account for the period after AAS cessation. The signs and symptoms of ASIH directly impact the observation of an increase in muscle mass and muscle strength from AAS administration and also reflect what is believed to demonstrate AAS dependency. More significantly, AAS prescribing after cessation adds the comorbid condition of hypogonadism to their already existing chronic illness. ASIH is critical towards any future planned use of AAS or similar compound to effect positive changes in muscle mass and muscle strength as well as an understanding for what has been termed anabolic steroid dependency. The further understanding and treatments that mitigate or prevent ASIH could contribute to androgen therapies for wasting associated diseases and stopping nonprescription AAS use. This paper proposes a unified hypothesis that the net effects for anabolic steroid administration must necessarily include the period after their cessation or ASIH.
DOI:
10.1016/j.mehy.2008.12.042
Abstract:
We report a case of reversible hypogonadism and azoospermia resulting from anabolic-androgenic steroid abuse in a body-builder with primary personality disorder. A keen body builder, a 20-year-old man, developed acute aggressive and destructive behavior after 10-month use of Bionabol (mean total dose of 1,120 mg per month), and Retabolil (mean total dose of 150 mg per month). He was found to meet the Diagnostic and Statistical Manual of Mental Disorders-IV ed. (DSM-IV) criteria for Borderline personality disorder. On admission to the hospital the clinical profile of the patient showed extremely low levels of serum testosterone. Values increased to normal levels 10 months after withdrawal of steroids. The semen was azoospermic at the beginning of the study period, oligospermic five months later, and reached 20 x 10(6) sperm per mL ten months after the steroid discontinuation. Anabolic steroids can greatly affect the male pituitary-gonadal axis. A hypogonadal state, characterized by decreased serum testosterone and impaired spermatogenesis, was induced in the patient. This condition was reversible after the steroid withdrawal, but the process took more than ten months. His personal imbalance could be considered a personality trait rather than a result of the anabolic-androgenic steroid use. There were probably dispositional personality characteristics that contributed to anabolic steroid abuse in our patient. The hypogonadal changes which occurred after his long-term steroid abuse were for the most part reversible.
Journal of Sports Medicine & Physical Fitness (J SPORTS MED PHYS FITNESS), 2000 Sep; 40 (3): 271-4. (32 ref)
Persistent primary hypogonadism associated with anabolic steroid abuse.
Fertility And Sterility [Fertil Steril] 2011 Jul; Vol. 96 (1), pp. e7-8. Date of Electronic Publication: 2011 May 14.
Abstract:
Objective: To report a case of primary gonadal failure due to the chronic abuse of anabolic steroids used for bodybuilding.
Design: Case report.
Setting: Department of Diabetes and Endocrinology, Morriston Hospital, Swansea, Wales, United Kingdom.
Patient(s): A 40-year-old man.
Intervention(s): None.
Main Outcome Measure(s): Clinical symptoms, levels of serum T, FSH, and LH.
Result(s): Primary gonadal failure resulting from anabolic steroid use.
Conclusion(s): We describe a case of initially secondary gonadal failure resulting from anabolic steroid use with subsequent primary gonadal failure and infertility. This case adds to the current literature and illustrates that the side effects of anabolic steroids can be prolonged and irreversible.
(Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.)
Substance Nomenclature:
0 (Anabolic Agents)
0 (Steroids)
3XMK78S47O (Testosterone)
6PG9VR430D (Nandrolone)
9002-72-6 (Growth Hormone)
DOI:
10.1016/j.fertnstert.2011.04.029
Anabolic steroid-induced hypogonadism--towards a unified hypothesis of anabolic steroid action.
Source: Medical Hypotheses [Med Hypotheses] 2009 Jun; Vol. 72 (6), pp. 723-8. Date of Electronic Publication: 2009 Feb 23.
Authors: Tan RS; HPT/Axis Inc., 1660 Beaconshire Road, Houston, TX 77077, USA.
Scally MC
Abstract:
Anabolic steroid-induced hypogonadism (ASIH) is the functional incompetence of the testes with subnormal or impaired production of testosterone and/or spermatozoa due to administration of androgens or anabolic steroids. Anabolic-androgenic steroid (AAS), both prescription and nonprescription, use is a cause of ASIH. Current AAS use includes prescribing for wasting associated conditions. Nonprescription AAS use is also believed to lead to AAS dependency or addiction. Together these two uses account for more than four million males taking AAS in one form or another for a limited duration. While both of these uses deal with the effects of AAS administration they do not account for the period after AAS cessation. The signs and symptoms of ASIH directly impact the observation of an increase in muscle mass and muscle strength from AAS administration and also reflect what is believed to demonstrate AAS dependency. More significantly, AAS prescribing after cessation adds the comorbid condition of hypogonadism to their already existing chronic illness. ASIH is critical towards any future planned use of AAS or similar compound to effect positive changes in muscle mass and muscle strength as well as an understanding for what has been termed anabolic steroid dependency. The further understanding and treatments that mitigate or prevent ASIH could contribute to androgen therapies for wasting associated diseases and stopping nonprescription AAS use. This paper proposes a unified hypothesis that the net effects for anabolic steroid administration must necessarily include the period after their cessation or ASIH.
DOI:
10.1016/j.mehy.2008.12.042
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