Isotretinoin/roaccutane comes in soft gelatine capsules - not to be cut, not to be removed from its blister for any reason other than ingesting it because it's particularly susceptible to degradation if exposed to a variety of stressors.
That said, I will never ever offer Isotretinoin again. A doctor I highly respect very recently explained to me the horrifying lifelong consequences taking Isotretinoin can have and that the first choice should be topical treatment with Adapalene (Differin), which takes months to work but doesn't potentially fuck you up for all the remaining months of your life, so as long as you have other options left, I'm convinced that Isotretinoin should be avoided at all costs.