ChaseIrons
Member
Ya the video footage of that panel should be released any day now. Can’t wait to clip those bits out for shorts and reels
MESO-Rx
Anabolic Steroids
AlexDavis43
Member
It's all relative. By all measures I'm more muscular than this other guy who works out at the same time as me every day.
My quads are better developed. But that motherfucker squats almost 100 pounds more than me easily and for reps.
Plate Smacker
Well-known Member
Has anyone that has ever done 2 grams or more ever noticed that the whites of their eyes is like... really really white?
Not a tinge of redness from capillaries?
I know, weirdest thing to even notice...
Not a tinge of redness from capillaries?
I know, weirdest thing to even notice...
eery
Well-known Member
Could it be because the rest of you are so red, that it gives you that illusion?
I cant say ive noticed that
ChaseIrons
Member
my face is too fat to see the whites
Astartes
Well-known Member
Hate those guys…. That’s why I bring my rubber bands to the gym…. and my Olympic plates… and my lift shoes… oh… and my bike helmet…(with SpongeBob stickers)
FYI, I forgot about this excellent recent thread by @Type-IIx addressing the topic of androgen receptor regulation that gives more detail too:AAS upregulation of androgen receptors is well-established. MESO first wrote about this 25 years ago:
Androgen Receptor Regulation
One of the most common beliefs concerning anabolic-androgenic steroid (AAS) usage is that the androgen receptor (AR) downregulates as a result of suchthinksteroids.com
Androgen Receptors Downregulate Don't They? Part 1
There is as much misinformation about steroids as there is good information had among bodybuilding enthusiasts. Go to any gym and you will hear some kid
Androgen Receptors Downregulate Don't They? Part 2
In part 1 of this article we discussed the mistake of thinking about androgen receptors (testosterone receptors) in the same way we think of other
The Myth of Desensitization to AAS; Four (4) Modes of Receptor Regulation & Upregulation of AR by AAS
I was requested by PM to address the claim that androgen receptor (AR) "resensitization" is a rationale for discontinuing AAS, meaning that supraphysiologic androgen dose (AUC; nmol * h/L) induces tachyphylaxis (desensitization) analogous to opioid/opiate & Opioid Receptors (i.e., κ-, δ-, μ- OR)...
thinksteroids.com
Also, it addresses something that was brought up earlier in the thread about bodybuilders at higher bodyweights requiring higher dosages that those at lower bodyweights:
Plate Smacker
Well-known Member
Great read... thanks...FYI, I forgot about this excellent recent thread by @Type-IIx addressing the topic of androgen receptor regulation that gives more detail too:
The Myth of Desensitization to AAS; Four (4) Modes of Receptor Regulation & Upregulation of AR by AAS
I was requested by PM to address the claim that androgen receptor (AR) "resensitization" is a rationale for discontinuing AAS, meaning that supraphysiologic androgen dose (AUC; nmol * h/L) induces tachyphylaxis (desensitization) analogous to opioid/opiate & Opioid Receptors (i.e., κ-, δ-, μ- OR)...
Also, it addresses something that was brought up earlier in the thread about bodybuilders at higher bodyweights requiring higher dosages that those at lower bodyweights:
Mongo966
Well-known Member
Type-IIx articles are great when my self-esteem is out of control and I need to be reminded of my place on the intellectual totem pole.FYI, I forgot about this excellent recent thread by @Type-IIx addressing the topic of androgen receptor regulation that gives more detail too:
The Myth of Desensitization to AAS; Four (4) Modes of Receptor Regulation & Upregulation of AR by AAS
I was requested by PM to address the claim that androgen receptor (AR) "resensitization" is a rationale for discontinuing AAS, meaning that supraphysiologic androgen dose (AUC; nmol * h/L) induces tachyphylaxis (desensitization) analogous to opioid/opiate & Opioid Receptors (i.e., κ-, δ-, μ- OR)...
Also, it addresses something that was brought up earlier in the thread about bodybuilders at higher bodyweights requiring higher dosages that those at lower bodyweights:
"What was the article about?" you ask?
I have no idea; I only had time to read it twice.
GuerillaPete
Well-known Member
I always thought cruising is for giving the organs a break and letting myostatin decrease because these hinder muscle growth.
Plate Smacker
Well-known Member
Found this somewhere... not sure of the validity though. Maybe a smart person could chime in.
Measurement of myostatin concentrations in human serum: Circulating concentrations in young and older men and effects of testosterone administration☆
Measurement of myostatin concentrations in human serum: Circulating concentrations in young and older men and effects of testosterone administration - PubMed
Myostatin ELISA has the characteristics of a valid assay: nearly 100% recovery, excellent precision, accuracy, and sufficient sensitivity to enable measurement of myostatin concentrations in men and women.
pubmed.ncbi.nlm.nih.gov
significantly higher on day 56 compared to baseline in both young and older men (Fig. 3A). Older men
experienced a significantly greater percent increase in myostatin levels than young men (Fig. 3B). The
increases in myostatin levels during testosterone therapy were not sustained; thus, serum myostatin levels on day 140 were not significantly different
from those at baseline. Changes in myostatin levels from baseline to day 56 were significantly positively
correlated with changes in total and free (Fig. 4C) testosterone concentrations in young men, but not in older men (Fig. 4B and D). As previously reported
testosterone treatment was associated with significant gains in lean body mass; the changes in lean body mass were significantly correlated with testosterone
dose and testosterone concentration (Bhasin et al.
2001, 2005)." 81 122
Last edited:
Who cares what the health costs are.... Thats for him and him alone to weigh up! He obviously thinks its worth it!
Plate Smacker
Well-known Member
Forgot to add this part... I'm a dummy.Found this somewhere... not sure of the validity though. Maybe a smart person could chime in.
Measurement of myostatin concentrations in human serum: Circulating concentrations in young and older men and effects of testosterone administration☆
Serum myostatin levels at baseline did not differ significantly across the five dose groups within either young or older men. Serum myostatin levels wereMeasurement of myostatin concentrations in human serum: Circulating concentrations in young and older men and effects of testosterone administration - PubMed
Myostatin ELISA has the characteristics of a valid assay: nearly 100% recovery, excellent precision, accuracy, and sufficient sensitivity to enable measurement of myostatin concentrations in men and women.
significantly higher on day 56 compared to baseline in both young and older men (Fig. 3A). Older men
experienced a significantly greater percent increase in myostatin levels than young men (Fig. 3B). The
increases in myostatin levels during testosterone therapy were not sustained; thus, serum myostatin levels on day 140 were not significantly different
from those at baseline. Changes in myostatin levels from baseline to day 56 were significantly positively
correlated with changes in total and free (Fig. 4C) testosterone concentrations in young men, but not in older men (Fig. 4B and D). As previously reported
testosterone treatment was associated with significant gains in lean body mass; the changes in lean body mass were significantly correlated with testosterone
dose and testosterone concentration (Bhasin et al.
2001, 2005)." 81 122
Copy paste from reddit... not my stuff.
"There is a common misbelief that myostatin increases the longer you are on cycle. The study I am about to post shows that that's not true.
They gave doses of up to 600 mg Test for 20 week and found that myostatin spiked at week 8 (day 56 when they measured myostatin concetration at Week 20 (day 140) it was back to baseline even in the 60mg group. From this information we can conclude longer, lower dose cycles are probaly more effective then shorter, high-dose ones."
Study: https://www.sciencedirect.com/science/art
/abs/pii/S0303720709000264 (You need to download PDF to read the full version)
ChaseIrons
Member
Sooo longer AND higher doses… got it
Plate Smacker
Well-known Member
And that's what I meant by "gotta get that AR Upregulation"....
And that's why I posted this Myostatin thingy.
It all points to one simple fact that has been effective but others are scared to venture or admit.... for fear of ridicule because they will be called liars, crazy, and careless... "think of the children.."
So we stick to the shadows, permablasting our lives away... and to what end?
It's a selfish existence.
I say permablast because coming down to 400mg Test is considered a blast to many...
And some only come down to 600.
Some more...
The people who perma are going to be bigger then those who do not, type 2x just posted a written assesment on the longer and more you grow on aas the more they will be effective because the muscle has more ability to use the dosage, and that someone who is bigger will actually respond better to lower doses then someone smaller because of the muscle being able to utilize the AAS. I believe this was the out one of his statements, i may have worded it poorly.
GuerillaPete
Well-known Member
In theory yes but in reality you can only redline the car for so long until the wheels start coming off.
Maintenance is needed its the same with the body.
Chase was off for year before this transformation and he is off now so he is not permablasting.
But people only learn the hard way….
@Type-IIx would sure have given some great lectures had he ever been a college professor. Those articles and his upcoming book would have made great papers and dissertations too.
Plate Smacker
Well-known Member
Something to consider:
Let's say I pin 3mL E4D of my 300mg/mL homebrew Test Decanoate (900mg E4D)
That's roughly 1800mg (1.8g) a week (8 days)
Only around 62mg of 100mg is Testosterone due to ester weight. 38% ester.
So 1800mg is about 1,116mg or 1.1g of Testosterone.
Next brew is 400mg/mL
3mL is 1200, twice a week 2400.
2400-38% is really 1488...
That's pinning a gram of ester weight...
Maybe the ester weight is where the gains are bro....
Let's say I pin 3mL E4D of my 300mg/mL homebrew Test Decanoate (900mg E4D)
That's roughly 1800mg (1.8g) a week (8 days)
Only around 62mg of 100mg is Testosterone due to ester weight. 38% ester.
So 1800mg is about 1,116mg or 1.1g of Testosterone.
Next brew is 400mg/mL
3mL is 1200, twice a week 2400.
2400-38% is really 1488...
That's pinning a gram of ester weight...
Maybe the ester weight is where the gains are bro....
He lied about his dosages. Simple as that
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