DNP + Semaglutide ?? Is running both safe ?? Will slow digestion be an issue ??

Tr3nbal0n3

New Member
I need to get absolutely shredded as soon as possible. Is it a bad idea to run DNP while also being on Semaglutide ? I came off DNP after a few days of being on it because of the intense hunger side effects it caused me to have. I almost messed up the diet a few times on it. I felt just as hungry on DNP as I did on MK677. I figured I’d use Semaglutide for appetite suppression + DNP for rapid fat loss.

I know GLP1 agonists slow down digestion, and my concern is having DNP pills in my stomach being digested slow sounds kinda scary. Especially since DNP can be deadly. The 36 hour half life of DNP + slow digestion leads me to believe something could potentially go wrong. Does anybody have any experience with running both compounds together?? Or does anyone know if it’s even safe to do so.
 
Solution
I need to get absolutely shredded as soon as possible. Is it a bad idea to run DNP while also being on Semaglutide ? I came off DNP after a few days of being on it because of the intense hunger side effects it caused me to have. I almost messed up the diet a few times on it. I felt just as hungry on DNP as I did on MK677. I figured I’d use Semaglutide for appetite suppression + DNP for rapid fat loss.

I know GLP1 agonists slow down digestion, and my concern is having DNP pills in my stomach being digested slow sounds kinda scary. Especially since DNP can be deadly. The 36 hour half life of DNP + slow digestion leads me to believe something could potentially go wrong. Does anybody have any experience with running both compounds...
I wouldn’t recommend it bro. I still have high creatinine levels, high Ast and Alt. Definitely did some damage to the liver and kidneys from the DNP.. on top of that I was using a low-dose and I didn’t really use it for a long period of time, yet it obliterated my bloodwork. 100% was not worth it, I should have just diet for a little longer without any Dnp.
how much mg of DNP did you take?
 
I wouldn’t recommend it bro. I still have high creatinine levels, high Ast and Alt. Definitely did some damage to the liver and kidneys from the DNP.. on top of that I was using a low-dose and I didn’t really use it for a long period of time, yet it obliterated my bloodwork. 100% was not worth it, I should have just diet for a little longer without any Dnp.
How high did ur creatinine got from dnp?
 
I'm not going on vacation. Those nasty slut hookers can’t even pay me to look at them..

I have cut naturally too many times you get tired of that shit. I’m doing it cause I want to get lean without starving to death.. On SEMA + DNP and I feel great, it’s working like magic.. Now I can effortlessly get lean without putting in any effort to do so. I’m focused on shit thats actually important.
You sound lazy and unmotivated, slightly pretentious lol
 
Just an observation. I want it and I want it now, but I don’t want to work hard. I get it, lots of guys out there like you
Just an observation. I want it and I want it now, but I don’t want to work hard. I get it, lots of guys out there

Just an observation. I want it and I want it now, but I don’t want to work hard. I get it, lots of guys out there like

Just an observation. I want it and I want it now, but I don’t want to work hard. I get it, lots of guys out there like you.
well I work too hard to pay rent, car payments, and bills. Honestly bro if I find shortcuts I take them. I know people look down on doing shit like Dnp. But unless they Zelle me next months rent, I will not take there opinion into consideration.
 
well I work too hard to pay rent, car payments, and bills. Honestly bro if I find shortcuts I take them. I know people look down on doing shit like Dnp. But unless they Zelle me next months rent, I will not take there opinion into consideration.
Not necessarily looking down...I agree with the short cut part in life and needing to pay the bills.

The problem is some shortcuts may mean paying next months rent doesn't matter (if you're dead...or even worse, disabled permanently).

It sounds like you learned that already (at least in regards to your kidneys and liver). Glad you advised the other dude NOT to do what you did and thanks for at least sharing your story of harm. I do hope it serves as a cautionary tale for those that are considering doing what you did.

I do mean the kudos to you though for following up and actually sharing your fuck up. I wonder how often some people post some "it's no big deal...just do it" advice and then never follow up with "I'm a fucking idiot and heading towards dialysis..." out of embarrassment for what they've done.
 
Not necessarily looking down...I agree with the short cut part in life and needing to pay the bills.

The problem is some shortcuts may mean paying next months rent doesn't matter (if you're dead...or even worse, disabled permanently).

It sounds like you learned that already (at least in regards to your kidneys and liver). Glad you advised the other dude NOT to do what you did and thanks for at least sharing your story of harm. I do hope it serves as a cautionary tale for those that are considering doing what you did.

I do mean the kudos to you though for following up and actually sharing your fuck up. I wonder how often some people post some "it's no big deal...just do it" advice and then never follow up with "I'm a fucking idiot and heading towards dialysis..." out of embarrassment for what they've done.
Yea, you’re 100% right. The scary part is I feel great. I had no clue that my liver and kidneys were about to explode. The only reason I know is cause of bloodwork. Someone else could do the same and have no idea something is going on and really mess themself up.
 
Yea, you’re 100% right. The scary part is I feel great. I had no clue that my liver and kidneys were about to explode. The only reason I know is cause of bloodwork. Someone else could do the same and have no idea something is going on and really mess themself up.
i am so confused how did it mess you up that bad when you took so little:(

who did you buy from? did they over dose you? because i've seen people do fine on 200-400 mg
 
i am so confused how did it mess you up that bad when you took so little:(

who did you buy from? did they over dose you? because i've seen people do fine on 200-400 mg
I got it from insightchem, I didnt crank the dosage at all though. I’m scared of Dnp, I have no idea where these dudes get the balls to go past 250mg.. You’re legit so hot on 250mg your balls keep sticking to your leg lmfaooo. I stayed at low dose the whole time. I was doing 250mg before I started taking it with Semaglutide. Then on sema I dropped to 125mg capsules. I read on another forum that your body only absorbs 70% - 80% of it when it’s crystal DNP. So I'm just assuming I was getting about 80mg, I’m not sure how true that is though. But I do think it had something to do with throwing in the Semaglutide that bodied my organs.
 
I need to get absolutely shredded as soon as possible. Is it a bad idea to run DNP while also being on Semaglutide ? I came off DNP after a few days of being on it because of the intense hunger side effects it caused me to have. I almost messed up the diet a few times on it. I felt just as hungry on DNP as I did on MK677. I figured I’d use Semaglutide for appetite suppression + DNP for rapid fat loss.

I know GLP1 agonists slow down digestion, and my concern is having DNP pills in my stomach being digested slow sounds kinda scary. Especially since DNP can be deadly. The 36 hour half life of DNP + slow digestion leads me to believe something could potentially go wrong. Does anybody have any experience with running both compounds together?? Or does anyone know if it’s even safe to do so.
If you want a faster metabolism then used rutatrutide combine with tirzepatide or sumaglutide for the appetiite suppression
 
Solution
Look, I understand wanting to lose weight...I truly do.

But this isn't Reddit. Let's at least stop propagating the wild west of GLP protocols.

We're all free to experiment however we want but combining Tirzepatide and Retatrutide has no rational basis. Maaaaaybe you can make an argument for Semaglutide and Tirzepatide...but we truly don't know the long term effects of combining,. mixing and matching..and what it does for any kind of immunogenicity and long term efficacy.

I have a stockpile of Reta that may just end up going "bad" eventually because Tirzepatide works for me AND Reta is still in clinical trials.

I'm all for the pioneers that are sticking to at least one compound at a time. For those mixing and matching, at least be clear there is ZERO clinical data to justify safety or even greater efficacy.

I am only pointing this out because I went through the "mixing and matching" interest phase myself but never got to mixing. Stick with a GLP protocol...give it 6+ months, and in the meantime, you still have to focus on the old tried and true "diet and exercise."

I'll be the first to admit the "diet and exercise" can always use some improvement. But we can't keep looking or hoping for any easier way to lose weight then what we've got at this point.

If truly trying to get shredded...well, I have zero doubt that is exactly the point where even MORE self-discipline and hard work will be crucial. No such thing as a free lunch...all of these meds have potential side effects. Carefully CALCULATED RISKS should be the name of the game...not random guess work.

I say all this not preaching or judging...just so that we can be clear how dangerously experimental all this shit can be. Good luck!
 
Look, I understand wanting to lose weight...I truly do.

But this isn't Reddit. Let's at least stop propagating the wild west of GLP protocols.

We're all free to experiment however we want but combining Tirzepatide and Retatrutide has no rational basis. Maaaaaybe you can make an argument for Semaglutide and Tirzepatide...but we truly don't know the long term effects of combining,. mixing and matching..and what it does for any kind of immunogenicity and long term efficacy.

I have a stockpile of Reta that may just end up going "bad" eventually because Tirzepatide works for me AND Reta is still in clinical trials.

I'm all for the pioneers that are sticking to at least one compound at a time. For those mixing and matching, at least be clear there is ZERO clinical data to justify safety or even greater efficacy.

I am only pointing this out because I went through the "mixing and matching" interest phase myself but never got to mixing. Stick with a GLP protocol...give it 6+ months, and in the meantime, you still have to focus on the old tried and true "diet and exercise."

I'll be the first to admit the "diet and exercise" can always use some improvement. But we can't keep looking or hoping for any easier way to lose weight then what we've got at this point.

If truly trying to get shredded...well, I have zero doubt that is exactly the point where even MORE self-discipline and hard work will be crucial. No such thing as a free lunch...all of these meds have potential side effects. Carefully CALCULATED RISKS should be the name of the game...not random guess work.

I say all this not preaching or judging...just so that we can be clear how dangerously experimental all this shit can be. Good luck!

Feel free to judge. MESO's mission is harm reduction. They're propagating the AAS equivalent of advising a teenager use Tren as TRT.

Out of an abundance of ignorance and arrogance, they've taken a proven, successful protocol for significant, sustained weight loss and outside of a handful of questionable anecdotes, do no better than, and usually worse than single compound users.

Are these people 600lbs? Is the fastest weight loss, on average, in history, too slow? lol

Wait until a large portion of this cohort who randomly switch and combine GLP class UGL drugs, often because "they stop working" (there's a clue something's gone very wrong, you don't develop "tolerance" to hormones) becomes completely insensitive to compounds you're supposed to stay on indefinitely. Who knows, perhaps they'll develop immunity to their own endogenous metabolic hormones, in the nightmare scenario the FDA and researchers have warned about.
 
Last edited:
Look, I understand wanting to lose weight...I truly do.

But this isn't Reddit. Let's at least stop propagating the wild west of GLP protocols.

We're all free to experiment however we want but combining Tirzepatide and Retatrutide has no rational basis. Maaaaaybe you can make an argument for Semaglutide and Tirzepatide...but we truly don't know the long term effects of combining,. mixing and matching..and what it does for any kind of immunogenicity and long term efficacy.

I have a stockpile of Reta that may just end up going "bad" eventually because Tirzepatide works for me AND Reta is still in clinical trials.

I'm all for the pioneers that are sticking to at least one compound at a time. For those mixing and matching, at least be clear there is ZERO clinical data to justify safety or even greater efficacy.

I am only pointing this out because I went through the "mixing and matching" interest phase myself but never got to mixing. Stick with a GLP protocol...give it 6+ months, and in the meantime, you still have to focus on the old tried and true "diet and exercise."

I'll be the first to admit the "diet and exercise" can always use some improvement. But we can't keep looking or hoping for any easier way to lose weight then what we've got at this point.

If truly trying to get shredded...well, I have zero doubt that is exactly the point where even MORE self-discipline and hard work will be crucial. No such thing as a free lunch...all of these meds have potential side effects. Carefully CALCULATED RISKS should be the name of the game...not random guess work.

I say all this not preaching or judging...just so that we can be clear how dangerously experimental all this shit can be. Good luck!
Its not wild I do it myself
And it was very effective

You probably injecting steroid like everyone else, so don’t talk about « potential risk » if you really care in a first place you wouldn’t be on them

And bro is using dnp i do believe rutatrutide is way safer than using dnp
 
Its not wild I do it myself
And it was very effective

You probably injecting steroid like everyone else, so don’t talk about « potential risk » if you really care in a first place you wouldn’t be on them

And bro is using dnp i do believe rutatrutide is way safer than using dnp

You don't knew what the fuck you're doing, and saying it's ok because it's "effective" confirms it. Protein therapeutics like peptides are nothing like conventional drugs, including AAS. There are unique risks you're completely unaware of.
 
You don't knew what the fuck you're doing, and saying it's ok because it's "effective" confirms it. Protein therapeutics like peptides are nothing like conventional drugs, including AAS. There are unique risks you're completely unaware of.
When you did a cycle, you used different stuff to have a synergi effect
Same thing with them
Better to used 5 mg tirze and 5mg ruta than 10mg only tirze or only ruta
 
Its not wild I do it myself
And it was very effective

You probably injecting steroid like everyone else, so don’t talk about « potential risk » if you really care in a first place you wouldn’t be on them

And bro is using dnp i do believe rutatrutide is way safer than using dnp
I run TRT - (I have dipped into TRT+ at times but this site has taught me it's not really worth pondering anything other than Test at sane levels until you get body fat down to reasonable levels).

So for full disclosure I currently run about 80-120 mg of Test cyp weekly. I occasionally add in 40-80 of Primo instead of Aromasin.

I have plenty of other compounds at my disposal but lingering here has again taught my they are pointless to use for cutting unless diet,. exercise and sleep are on point (which is rare for me in my career right now).

I understand where you might see some hypocrisy in my advice. You are free to self-experiment as you see fit. Just be open to the possibility you're wrong and be willing to change course.

I implore you to at least qualify your advice on meds being run with "there is zero scientific evidence to support this suggestion." It is possible the evidence will change as time goes on. It's possible you have done more research and know more anecdotal reports for the advice you are suggesting (combining Reta and Tirzepatide) but we really need to be careful about propagating these mixes of GLPs. I'm truly not trying to preach to you.

I presume you're an adult and and are free to do as you see fit. But we need to be clearer on the advice offered in this forum... it's either:
- i. Scientific fact: cite sources

- ii. Anecdotal reports: n = (hopefully a high number of people from various walks of life)

- III. Bro-science. ... let's eliminate bro-science in here. We're generally a classier group of drug addicts...lol
 
Back
Top