MANWHORE
Subscriber
Xenoestrogens found in Peeps and Little Debbies..
What the hell!!! Well, there goes my diet
What the hell!!! Well, there goes my diet
MESO-Rx
Anabolic Steroids
Endocrine-Disrupting Chemicals
- Thread starter BBC3
- Start date
I subscribed to Kentwood water service about a year ago and the rep seemed knowlegeable so I quizzed him.
You should already understand that the rating on plastics should be on the bottom in a triangle ranging from 1 to 12 or something like that. I THINK that the higher the number the SOFTER the plastic. So here was the dilemna so it seemed. First he stated that they only re-use their plastic bottles about 20 times and that they are date stampted somewhere as most people receive water that was caught within a couple days.. I have not checked to hold them up to that.
But the long and short was that they use the lowest number possible in order to reduce the dispersion of plastic into the water, else it would be so hard it cracked just sttting it on the floor. Imagine asbestos and fryability. The harder the overall substance, the less likely it is to disperse particles in the air when disturbed (broken).
But the long and short is that anything stored in plastic starts to disperse material into the product with TIME & HEAT. So the last thing you want to do is buy gallons of water and set them in the garage to cook over time. I wonder is there an initial release factor upon bottling ??!?!?!?
So the point is that you must consider the product that the BPA is protecting. A pizza box for example is extremely FRYABLE (spelling) so you want to be sure they are putting some wax paper under the pie.!!! Everything is in plastic today. It would be interesting to see solubiity factors, POLARITY, and other considerations. For example is a coke in a two liter more likely to absorb BPA than a plastic jar of mayonase.....?
You should already understand that the rating on plastics should be on the bottom in a triangle ranging from 1 to 12 or something like that. I THINK that the higher the number the SOFTER the plastic. So here was the dilemna so it seemed. First he stated that they only re-use their plastic bottles about 20 times and that they are date stampted somewhere as most people receive water that was caught within a couple days.. I have not checked to hold them up to that.
But the long and short was that they use the lowest number possible in order to reduce the dispersion of plastic into the water, else it would be so hard it cracked just sttting it on the floor. Imagine asbestos and fryability. The harder the overall substance, the less likely it is to disperse particles in the air when disturbed (broken).
But the long and short is that anything stored in plastic starts to disperse material into the product with TIME & HEAT. So the last thing you want to do is buy gallons of water and set them in the garage to cook over time. I wonder is there an initial release factor upon bottling ??!?!?!?
So the point is that you must consider the product that the BPA is protecting. A pizza box for example is extremely FRYABLE (spelling) so you want to be sure they are putting some wax paper under the pie.!!! Everything is in plastic today. It would be interesting to see solubiity factors, POLARITY, and other considerations. For example is a coke in a two liter more likely to absorb BPA than a plastic jar of mayonase.....?
The Disappearing Male
[ame=http://vimeo.com/15346778]The Disappearing Male on Vimeo[/ame]
[ame=http://vimeo.com/15346778]The Disappearing Male on Vimeo[/ame]
JakeZ
New Member
I think this is done on purpose. They want to decrease the population.
Has someone insisted you drink BPA in the past?
[China] Exposure to Bisphenol-A and Reproductive Hormones among Male Adults
Highlights
• The potential risk of BPA to human health is very significant.
• Ours is the first study on BPA and hormones in a large sample of Chinese males.
• Urine BPA was associated with increased prolactin, estrodiol, and SHBG level.
• Urine BPA was associated with reduced inhibin B and androstenedione level.
Liu X, Miao M, Zhou Z, Gao E, Chen J, et al. Exposure to bisphenol-A and reproductive hormones among male adults. Environ Toxicol Pharmacol. 2015;39(2):934-41. https://www.sciencedirect.com/science/article/pii/S138266891500071X
BACKGROUND: Bisphenol A (BPA) is a suspected human endocrine disruptor which is widely used.
METHODS: In order to determine whether urine BPA level is associated with serum reproductive hormone levels among male adults, we carried out a cross-sectional study in China. We recruited 592 male workers and collected their urine samples for BPA measurement. We also collected blood samples and examined serum reproductive hormones. We used multiple linear regression and log-binomial model to examine associations between urine BPA level and hormone levels after controlling for age and smoking status.
RESULTS: An increased urine BPA level was associated with increased prolactin (p<0.001), estradiol (p<0.001), sex hormone-binding globulin level (p=0.001), and a reduced androstenedione (p<0.001) and free androgen index level (p=0.021). Males, whose urine BPA level was in the 2nd, 3rd and highest quartiles, had respectively 1.58, 1.33 and 3.09-fold increased prevalence of having a high prolactin level (>P75 level). The highest quartile of BPA level was associated with 1.63 and 1.50-fold increased prevalence of having a high estradiol and elevated sex hormone-binding globulin level. Males with higher quartile of BPA level had a lower inhibin B level.
CONCLUSION: High BPA exposure is associated with increased prolactin, estradiol and sex hormone-binding globulin level in males, and may contribute to male infertility.
Highlights
• The potential risk of BPA to human health is very significant.
• Ours is the first study on BPA and hormones in a large sample of Chinese males.
• Urine BPA was associated with increased prolactin, estrodiol, and SHBG level.
• Urine BPA was associated with reduced inhibin B and androstenedione level.
Liu X, Miao M, Zhou Z, Gao E, Chen J, et al. Exposure to bisphenol-A and reproductive hormones among male adults. Environ Toxicol Pharmacol. 2015;39(2):934-41. https://www.sciencedirect.com/science/article/pii/S138266891500071X
BACKGROUND: Bisphenol A (BPA) is a suspected human endocrine disruptor which is widely used.
METHODS: In order to determine whether urine BPA level is associated with serum reproductive hormone levels among male adults, we carried out a cross-sectional study in China. We recruited 592 male workers and collected their urine samples for BPA measurement. We also collected blood samples and examined serum reproductive hormones. We used multiple linear regression and log-binomial model to examine associations between urine BPA level and hormone levels after controlling for age and smoking status.
RESULTS: An increased urine BPA level was associated with increased prolactin (p<0.001), estradiol (p<0.001), sex hormone-binding globulin level (p=0.001), and a reduced androstenedione (p<0.001) and free androgen index level (p=0.021). Males, whose urine BPA level was in the 2nd, 3rd and highest quartiles, had respectively 1.58, 1.33 and 3.09-fold increased prevalence of having a high prolactin level (>P75 level). The highest quartile of BPA level was associated with 1.63 and 1.50-fold increased prevalence of having a high estradiol and elevated sex hormone-binding globulin level. Males with higher quartile of BPA level had a lower inhibin B level.
CONCLUSION: High BPA exposure is associated with increased prolactin, estradiol and sex hormone-binding globulin level in males, and may contribute to male infertility.
Well This should help you sleep better at night. It appears they are coming out with two new untested versions...
http://time.com/3742871/bpa-free-health/
http://time.com/3742871/bpa-free-health/
Gore AC, Chappell VA, Fenton SE, et al. EDC-2: The Endocrine Society’s Second Scientific Statement on Endocrine-Disrupting Chemicals. Endocrine Reviews. http://press.endocrine.org/doi/abs/10.1210/er.2015-1010
The Endocrine Society’s first Scientific Statement in 2009 provided a wake-up call to the scientific community about how environmental endocrine-disrupting chemicals (EDCs) affect health and disease.
Five years later, a substantially larger body of literature has solidified our understanding of plausible mechanisms underlying EDC actions and how exposures in animals and humans—especially during development—may lay the foundations for disease later in life.
At this point in history, we have much stronger knowledge about how EDCs alter gene-environment interactions via physiological, cellular, molecular, and epigenetic changes, thereby producing effects in exposed individuals as well as their descendants.
Causal links between exposure and manifestation of disease are substantiated by experimental animal models and are consistent with correlative epidemiological data in humans.
There are several caveats because differences in how experimental animal work is conducted can lead to difficulties in drawing broad conclusions, and we must continue to be cautious about inferring causality in humans.
In this second Scientific Statement, we reviewed the literature on a subset of topics for which the translational evidence is strongest:
1) obesity and diabetes;
2) female reproduction;
3) male reproduction;
4) hormone-sensitive cancers in females;
5) prostate;
6) thyroid; and
7) neurodevelopment and neuroendocrine systems.
Our inclusion criteria for studies were those conducted predominantly in the past 5 years deemed to be of high quality based on appropriate negative and positive control groups or populations, adequate sample size and experimental design, and mammalian animal studies with exposure levels in a range that was relevant to humans.
We also focused on studies using the developmental origins of health and disease model. No report was excluded based on a positive or negative effect of the EDC exposure. The bulk of the results across the board strengthen the evidence for endocrine health-related actions of EDCs.
Based on this much more complete understanding of the endocrine principles by which EDCs act, including nonmonotonic dose-responses, low-dose effects, and developmental vulnerability, these findings can be much better translated to human health.
Armed with this information, researchers, physicians, and other healthcare providers can guide regulators and policymakers as they make responsible decisions.
The Endocrine Society’s first Scientific Statement in 2009 provided a wake-up call to the scientific community about how environmental endocrine-disrupting chemicals (EDCs) affect health and disease.
Five years later, a substantially larger body of literature has solidified our understanding of plausible mechanisms underlying EDC actions and how exposures in animals and humans—especially during development—may lay the foundations for disease later in life.
At this point in history, we have much stronger knowledge about how EDCs alter gene-environment interactions via physiological, cellular, molecular, and epigenetic changes, thereby producing effects in exposed individuals as well as their descendants.
Causal links between exposure and manifestation of disease are substantiated by experimental animal models and are consistent with correlative epidemiological data in humans.
There are several caveats because differences in how experimental animal work is conducted can lead to difficulties in drawing broad conclusions, and we must continue to be cautious about inferring causality in humans.
In this second Scientific Statement, we reviewed the literature on a subset of topics for which the translational evidence is strongest:
1) obesity and diabetes;
2) female reproduction;
3) male reproduction;
4) hormone-sensitive cancers in females;
5) prostate;
6) thyroid; and
7) neurodevelopment and neuroendocrine systems.
Our inclusion criteria for studies were those conducted predominantly in the past 5 years deemed to be of high quality based on appropriate negative and positive control groups or populations, adequate sample size and experimental design, and mammalian animal studies with exposure levels in a range that was relevant to humans.
We also focused on studies using the developmental origins of health and disease model. No report was excluded based on a positive or negative effect of the EDC exposure. The bulk of the results across the board strengthen the evidence for endocrine health-related actions of EDCs.
Based on this much more complete understanding of the endocrine principles by which EDCs act, including nonmonotonic dose-responses, low-dose effects, and developmental vulnerability, these findings can be much better translated to human health.
Armed with this information, researchers, physicians, and other healthcare providers can guide regulators and policymakers as they make responsible decisions.
Contaminating Our Bodies With Everyday Products
http://www.nytimes.com/2015/11/29/o...-with-everyday-products.html?ref=opinion&_r=0
IN recent weeks, two major medical organizations have issued independent warnings about toxic chemicals in products all around us.
Unregulated substances, they say, are sometimes linked to breast and prostate cancer, genital deformities, obesity, diabetes and infertility.
The warnings are a reminder that the chemical industry has inherited the mantle of Big Tobacco, minimizing science and resisting regulation in ways that cause devastating harm to unsuspecting citizens.
“Widespread exposure to toxic environmental chemicals threatens healthy human reproduction,” the International Federation of Gynecology and Obstetrics warned in a landmark statement last month. http://www.figo.org/sites/default/files/uploads/News/Final PDF_8462.pdf
The other major organization that recently issued a warning is the Endocrine Society, the international association of doctors and scientists who deal with the hormone system. https://www.endocrine.org/news-room...posure-linked-to-rising-diabetes-obesity-risk
http://www.nytimes.com/2015/11/29/o...-with-everyday-products.html?ref=opinion&_r=0
IN recent weeks, two major medical organizations have issued independent warnings about toxic chemicals in products all around us.
Unregulated substances, they say, are sometimes linked to breast and prostate cancer, genital deformities, obesity, diabetes and infertility.
The warnings are a reminder that the chemical industry has inherited the mantle of Big Tobacco, minimizing science and resisting regulation in ways that cause devastating harm to unsuspecting citizens.
“Widespread exposure to toxic environmental chemicals threatens healthy human reproduction,” the International Federation of Gynecology and Obstetrics warned in a landmark statement last month. http://www.figo.org/sites/default/files/uploads/News/Final PDF_8462.pdf
The other major organization that recently issued a warning is the Endocrine Society, the international association of doctors and scientists who deal with the hormone system. https://www.endocrine.org/news-room...posure-linked-to-rising-diabetes-obesity-risk
Hauser R, Skakkebaek NE, Hass U, et al. Male Reproductive Disorders, Diseases, and Costs of Exposure to Endocrine-Disrupting Chemicals in the European Union. The Journal of Clinical Endocrinology & Metabolism 2015;100(4):1267-77. http://press.endocrine.org/doi/10.1210/jc.2014-4325
Introduction: Increasing evidence suggests that endocrine-disrupting chemicals (EDCs) contribute to male reproductive diseases and disorders.
Purpose: To estimate the incidence/prevalence of selected male reproductive disorders/diseases and associated economic costs that can be reasonably attributed to specific EDC exposures in the European Union (EU).
Methods: An expert panel evaluated evidence for probability of causation using the Intergovernmental Panel on Climate Change weight-of-evidence characterization. Exposure-response relationships and reference levels were evaluated, and biomarker data were organized from carefully identified studies from the peer-reviewed literature to represent European exposure and approximate burden of disease as it occurred in 2010. The cost-of-illness estimation utilized multiple peer-reviewed sources.
Results: The expert panel identified low epidemiological and strong toxicological evidence for male infertility attributable to phthalate exposure, with a 40–69% probability of causing 618 000 additional assisted reproductive technology procedures, costing €4.71 billion annually.
Low epidemiological and strong toxicological evidence was also identified for cryptorchidism due to prenatal polybrominated diphenyl ether exposure, resulting in a 40–69% probability that 4615 cases result, at a cost of €130 million (sensitivity analysis, €117–130 million).
A much more modest (0–19%) probability of causation in testicular cancer by polybrominated diphenyl ethers was identified due to very low epidemiological and weak toxicological evidence, with 6830 potential cases annually and costs of €848 million annually (sensitivity analysis, €313–848 million).
The panel assigned 40–69% probability of lower T concentrations in 55- to 64-year-old men due to phthalate exposure, with 24 800 associated deaths annually and lost economic productivity of €7.96 billion.
Conclusions: EDCs may contribute substantially to male reproductive disorders and diseases, with nearly €15 billion annual associated costs in the EU. These estimates represent only a few EDCs for which there were sufficient epidemiological studies and those with the highest probability of causation. These public health costs should be considered as the EU contemplates regulatory action on EDCs.
Introduction: Increasing evidence suggests that endocrine-disrupting chemicals (EDCs) contribute to male reproductive diseases and disorders.
Purpose: To estimate the incidence/prevalence of selected male reproductive disorders/diseases and associated economic costs that can be reasonably attributed to specific EDC exposures in the European Union (EU).
Methods: An expert panel evaluated evidence for probability of causation using the Intergovernmental Panel on Climate Change weight-of-evidence characterization. Exposure-response relationships and reference levels were evaluated, and biomarker data were organized from carefully identified studies from the peer-reviewed literature to represent European exposure and approximate burden of disease as it occurred in 2010. The cost-of-illness estimation utilized multiple peer-reviewed sources.
Results: The expert panel identified low epidemiological and strong toxicological evidence for male infertility attributable to phthalate exposure, with a 40–69% probability of causing 618 000 additional assisted reproductive technology procedures, costing €4.71 billion annually.
Low epidemiological and strong toxicological evidence was also identified for cryptorchidism due to prenatal polybrominated diphenyl ether exposure, resulting in a 40–69% probability that 4615 cases result, at a cost of €130 million (sensitivity analysis, €117–130 million).
A much more modest (0–19%) probability of causation in testicular cancer by polybrominated diphenyl ethers was identified due to very low epidemiological and weak toxicological evidence, with 6830 potential cases annually and costs of €848 million annually (sensitivity analysis, €313–848 million).
The panel assigned 40–69% probability of lower T concentrations in 55- to 64-year-old men due to phthalate exposure, with 24 800 associated deaths annually and lost economic productivity of €7.96 billion.
Conclusions: EDCs may contribute substantially to male reproductive disorders and diseases, with nearly €15 billion annual associated costs in the EU. These estimates represent only a few EDCs for which there were sufficient epidemiological studies and those with the highest probability of causation. These public health costs should be considered as the EU contemplates regulatory action on EDCs.
GarageLifter
New Member
My uneducated two cents.
Keep visceral belly fat to an absolute minimum. Chemicals love fat.
To lose the belly fat, you must eat less. The less you eat, the less amount chemicals in your body. Your heart doesn't have to pump blood to the fat, giving more energy to live life. Seems simple enough.
The people in the past were healthier because they were thinner. They had very thin waistlines.
Keep visceral belly fat to an absolute minimum. Chemicals love fat.
To lose the belly fat, you must eat less. The less you eat, the less amount chemicals in your body. Your heart doesn't have to pump blood to the fat, giving more energy to live life. Seems simple enough.
The people in the past were healthier because they were thinner. They had very thin waistlines.
hardasnails1973
New Member
If we can revert our chemistry back to pre 1970..Problem solved...
Associations of Bisphenol A and Polychlorinated Biphenyls with Spermatogenesis and Steroidogenesis
Highlights
· PCB levels negatively correlated with androgen concentrations.
· Bisphenol A negatively correlated with sperm count, concentration and morphology.
· BPA was associated with increased estrogen levels in both plasma and seminal plasma.
· BPA was associated with lower steroidogenesis in testis, but greater in adrenals.
Vitku J, Heracek J, Sosvorova L, et al. Associations of bisphenol A and polychlorinated biphenyls with spermatogenesis and steroidogenesis in two biological fluids from men attending an infertility clinic. Environ Int 2016;89-90:166-73. Associations of bisphenol A and polychlorinated biphenyls with spermatogenesis and steroidogenesis in two biological fluids from men attending an infertility clinic
BACKGROUND: In the testis, steroid hormones play an important role in spermatogenesis, the production of semen, and the maintenance of secondary sex characteristics and libido. They may also play a role as a target for substances called endocrine disruptors (EDs). As yet, however, no complex study has been conducted evaluating the relationships between EDs and the steroid spectrum in the plasma and seminal plasma.
OBJECTIVES: To shed more light into mechanisms of EDs and the effects of bisphenol A (BPA) and polychlorinated biphenyls (PCBs) on human spermatogenesis and steroidogenesis. METHODS: We determined BPA and 11 steroids in the plasma and seminal plasma of 191 men with different degrees of fertility, using a newly developed liquid-chromatography mass spectrometry method. Concurrently, plasma levels of 6 congeners of PCBs, gonadotropins, selenium, zinc and homocysteine were measured. Partial correlations adjusted for age, BMI and abstinence time were performed to evaluate relationships between these analytes.
RESULTS: Seminal BPA, but not plasma BPA, was negatively associated with sperm concentration (r=-0.198; p=0.009), sperm count (r=-0.178; p=0.018) and morphology (r=-0.160; p=0.044). Divergent and sometimes opposing associations of steroids and BPA were found in both body fluids. The sum of PCB congeners was negatively associated with testosterone, free testosterone, the free androgen index and dihydrotestosterone in plasma.
CONCLUSION: BPA may negatively contribute to the final state of sperm quality. Moreover, our data indicate that BPA influences human gonadal and adrenal steroidogenesis at various steps. Environmental levels of PCBs negatively correlated with androgen levels, but surprisingly without negative effects on sperm quality.
Highlights
· PCB levels negatively correlated with androgen concentrations.
· Bisphenol A negatively correlated with sperm count, concentration and morphology.
· BPA was associated with increased estrogen levels in both plasma and seminal plasma.
· BPA was associated with lower steroidogenesis in testis, but greater in adrenals.
Vitku J, Heracek J, Sosvorova L, et al. Associations of bisphenol A and polychlorinated biphenyls with spermatogenesis and steroidogenesis in two biological fluids from men attending an infertility clinic. Environ Int 2016;89-90:166-73. Associations of bisphenol A and polychlorinated biphenyls with spermatogenesis and steroidogenesis in two biological fluids from men attending an infertility clinic
BACKGROUND: In the testis, steroid hormones play an important role in spermatogenesis, the production of semen, and the maintenance of secondary sex characteristics and libido. They may also play a role as a target for substances called endocrine disruptors (EDs). As yet, however, no complex study has been conducted evaluating the relationships between EDs and the steroid spectrum in the plasma and seminal plasma.
OBJECTIVES: To shed more light into mechanisms of EDs and the effects of bisphenol A (BPA) and polychlorinated biphenyls (PCBs) on human spermatogenesis and steroidogenesis. METHODS: We determined BPA and 11 steroids in the plasma and seminal plasma of 191 men with different degrees of fertility, using a newly developed liquid-chromatography mass spectrometry method. Concurrently, plasma levels of 6 congeners of PCBs, gonadotropins, selenium, zinc and homocysteine were measured. Partial correlations adjusted for age, BMI and abstinence time were performed to evaluate relationships between these analytes.
RESULTS: Seminal BPA, but not plasma BPA, was negatively associated with sperm concentration (r=-0.198; p=0.009), sperm count (r=-0.178; p=0.018) and morphology (r=-0.160; p=0.044). Divergent and sometimes opposing associations of steroids and BPA were found in both body fluids. The sum of PCB congeners was negatively associated with testosterone, free testosterone, the free androgen index and dihydrotestosterone in plasma.
CONCLUSION: BPA may negatively contribute to the final state of sperm quality. Moreover, our data indicate that BPA influences human gonadal and adrenal steroidogenesis at various steps. Environmental levels of PCBs negatively correlated with androgen levels, but surprisingly without negative effects on sperm quality.
THERE’S A NEW reason to be concerned about toxic chemicals used in nonstick pans, waterproof products, and firefighting foam: PFOA and PFOS impair male reproductive health, according to a study released in early November.
Researchers have already documented that PFOA and PFOS, two compounds in a class known as PFAS, reduce the fertility of male mice, rats, and rabbits. The new study, published by the Journal of Clinical Endocrinology and Metabolism, shows that young men exposed to the chemicals have a range of problems with their reproductive systems — and also lays out for the first time how these chemicals interfere with hormones inside the cell.
The research was conducted in Veneto, Italy, one of several areas of the world where industrial use of PFAS has caused drinking water contamination and led to the chemicals accumulating in people’s blood. The mid-Ohio Valley, where a DuPont plant released the chemicals into the Ohio River, is another.
The researchers compared male high school students who had been exposed to high levels of PFOA and PFOS in Veneto to young men who hadn’t been exposed and found that those in the exposed group had shorter penises, lower sperm counts, lower sperm mobility, and a reduction in “anogenital distance,” a measure that scientists see as a marker of reproductive health. The percentage of normally shaped sperm in the exposed group was just over half that in the control group.
The chemicals “have a substantial impact on human male health as they directly interfere with hormonal pathways potentially leading to male infertility,” the scientists concluded in the article, which was peer reviewed and published on November 6.
After observing the abnormalities in the young men, whose average age was 18, the researchers probed further to see how the chemicals might be affecting their reproductive development. Experiments they conducted in the laboratory show that PFOA and PFOS can bind with testosterone receptors inside the cell and disrupt the normal function of the hormone.
...
Di Nisio A, Sabovic I, Valente U, et al. Endocrine disruption of androgenic activity by perfluoroalkyl substances: clinical and experimental evidence. The Journal of Clinical Endocrinology & Metabolism 2018:jc.2018-01855-jc.2018-. Endocrine disruption of androgenic activity by perfluoroalkyl substances: clinical and experimental evidence / https://assets.documentcloud.org/documents/5316830/EDCs-Androgenic-Activity-Perfluoroakyl.pdf
Background - Considerable attention has been paid to perfluoroalkyl compounds (PFCs) because of their worldwide presence in humans, wildlife, and environment. A wide variety of toxicological effects is well supported in animals, including testicular toxicity and male infertility. For these reasons, the understanding of epidemiological associations and of the molecular mechanisms involved in the endocrine-disrupting properties of PFCs on human reproductive health is a major concern.
Objective - To investigate the relationship between PFCs exposure and male reproductive health.
Design - This study was performed within a screening protocol to evaluate male reproductive health in high schools.
Patients - this is a cross-sectional study on 212 exposed males from the Veneto region, one of the four areas worldwide heavily polluted with PFCs, and 171 non-exposed controls.
Main outcome measures - Anthropometrics, seminal parameters and sex hormones were measured in young males from exposed areas, compared with age-matched controls. We also performed biochemical studies in established experimental models.
Results - We found that increased levels of PFCs in plasma and seminal fluid positively correlate with circulating T and with a reduction of semen quality, testicular volume, penile length and AGD. Experimental evidence points towards an antagonistic action of PFOA on the binding of T to AR in gene reporter assay, competition assay on AR-coated SPR chip and AR nuclear translocation assay.
Discussion - This study documents that PFCs have a substantial impact on human health as they interfere with hormonal pathways, potentially leading to male infertility.
This is an excellent thread giving insights into what we are being exposed to, as well as long term official knowledge of it. It’s shameful, but that’s what happens to humans when you give them power and money
View: https://twitter.com/michaelscally/status/1363474569810612226?s=20
Something alarming is happening between our legs.
Sperm counts have been dropping; infant boys are developing more genital abnormalities; more girls are experiencing https://centerforhealthjournalism.org/2016/06/22/precocious-puberty-girls-increasing-and-alarming#:~:text=Sixteen%20percent%20of%20U.S.%20girls,not%20agree%20on%20the%20reasons.; and adult women appear to be suffering declining egg quality and more miscarriages.
It’s not just humans. Scientists report genital anomalies in a range of species, including unusually small penises in alligators, otters and minks. In some areas, significant numbers of fish, frogs and turtles have exhibited both male and female organs.
Four years ago, a leading scholar of reproductive health, Shanna H. Swan, calculated that from 1973 to 2011, the sperm count of average men in Western countries had fallen by 59 percent. Inevitably, there were headlines about “Spermageddon” and the risk that humans would disappear, but then we moved on to chase other shiny objects.
Now Swan, an epidemiologist at Mount Sinai Medical Center in New York, has written a book, “Count Down,” that will be published on Tuesday and sounds a warning bell. Her subtitle is blunt: “How our modern world is threatening sperm counts, altering male and female reproductive development, and imperiling the future of the human race.”
View: https://twitter.com/michaelscally/status/1363475127669776384?s=20
In the tradition of Silent Spring and The Sixth Extinction, an urgent, meticulously researched, and groundbreaking book about the ways in which chemicals in the modern environment are changing—and endangering—human sexuality and fertility on the grandest scale, from renowned epidemiologist Shanna Swan.
Phthalates...
www.cnn.com
Chemicals in plastics damage babies' brains and must be banned, expert group says
Human-made chemicals in the plastics we use are damaging children's brain development and must be banned immediately, according to a group of scientists dedicated to studying and reducing kids' exposure to neurotoxic chemicals and pollutants.
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