Endocrine-Disrupting Chemicals

[liftermo]

Re: Environmental Factors and Low T

so basically live a perfect life in a totally phuked up world!!!

Its not diffiuclt. it just requires organisation.

Let em give an example.

1.Distill your water in the evenings - get the waterwise distiller, set it on and let it do its job. Thats your water taken care of.

2.Try and buy organic, it does not cost that much more anymore, organic is quite accessible. If you cant get orgainc, just do the fruit and veg clean as advocated by the juiceman - Juice of half a lemon and a couple of table spoons of salt, fill the sink tub up and allow veg and fruit to soak for 15 minutes. Clean, drain and store away.

3.Use metalic water bottles, avoid plastic storage, avoid plastic as much as possible.

4.Eat some of the following everyday - broccoli, broccoli, cabbage sporuts, kale etc alternating everyday if you want to balance. Make sure you cook the goitergenic ones though

5.Do a liver cleanse, regularly, the hulda clarke liver cleanse is good. This helps your body get rid of excess estrogens.

6.Avoid all drugs, cigarettes, alcohol and even prescription drugs as best you can.

7.Avoid additives, chemicals, preservatives the best you can

8.Eat simple foods, in their most natural state as much as you can.

9.Go to bed early and wake up refreshed naturally, try and sleep as much as your body needs everyday. Do your best.

10.Avoid microwaves, mobile phones as much as posisble and anything high tech and modern.

10. Control physical stress - dont excersize beyond your means - excersize drives up cortisol - recovery, rest and relaxation is very important. Infact many people become hypogonadal through excess weight training, cardio training etc. Training too much and too hard is the single most cause for hormone issues among young men in my opinion. Remember in the old days all this weight training and excersize would be like manual labour! Dont do HIT style weight training, that has screwed up many young men, its may work for some but the majority suffer from it so avoid it is best advice.

11.Control mental and emotional stress - this deplets adrenals, cause low testosterone through high cortisol. 'dont sweat the small stuff, its all small stuff'. Try and detach yourself from situations that rouse you emotionally and train yourself to not let things get to you. It will lead to a happier and healthier life.

12.Conduct regular relaxation - do meditation, deep breathing, listen to claming music, whatever allows you to unwind for at least 15 minutes everyday. No matter how busy someone is they can find 15 minutes to relax. If you have the time a nap is even better.

13.Dont have excess sex, only have sex when you are reallly horny. Too much sex is a stressor as well, it taxes internal glands organs. Allow yourself to fel the hunger before you enagage - and by that i dont mean the hunger that arises when you become stimulated, it means the internal needs for release that builds up naturally and you feel the need to release. Everyone can get stimulated and build this hunger, this is wrong so dont look at too much porn. It stressors the glands which imo leads to problems.


These simple rules will allow you to live in modern society and retain good helath, hormone levels and live a healthy and happy life. Its not difficult to do either.

 

[knarlomatic]

Re: Environmental Factors and Low T

Thanks liftermo, good advice. I can see Imrj's point too. When I was a kid we no one worried about these things. But those were different times.

 

[imrj]

Re: Environmental Factors and Low T

good post as well.....is just really tough out there man, am not just a single guy any more in my 20's looking to get laid...am nearly 40 now, married with 3 kids and the single income for the family......even drinking the right water becomes 20 times as hard!!!

 

[Substance P]

Re: Environmental Factors and Low T

so basically live a perfect life in a totally phuked up world!!!

Its not diffiuclt. it just requires organisation.

Let em give an example.

1.Distill your water in the evenings - get the waterwise distiller, set it on and let it do its job. Thats your water taken care of.

2.Try and buy organic, it does not cost that much more anymore, organic is quite accessible. If you cant get orgainc, just do the fruit and veg clean as advocated by the juiceman - Juice of half a lemon and a couple of table spoons of salt, fill the sink tub up and allow veg and fruit to soak for 15 minutes. Clean, drain and store away.

3.Use metalic water bottles, avoid plastic storage, avoid plastic as much as possible.

4.Eat some of the following everyday - broccoli, broccoli, cabbage sporuts, kale etc alternating everyday if you want to balance. Make sure you cook the goitergenic ones though

5.Do a liver cleanse, regularly, the hulda clarke liver cleanse is good. This helps your body get rid of excess estrogens.

6.Avoid all drugs, cigarettes, alcohol and even prescription drugs as best you can.

7.Avoid additives, chemicals, preservatives the best you can

8.Eat simple foods, in their most natural state as much as you can.

9.Go to bed early and wake up refreshed naturally, try and sleep as much as your body needs everyday. Do your best.

10.Avoid microwaves, mobile phones as much as posisble and anything high tech and modern.

10. Control physical stress - dont excersize beyond your means - excersize drives up cortisol - recovery, rest and relaxation is very important. Infact many people become hypogonadal through excess weight training, cardio training etc. Training too much and too hard is the single most cause for hormone issues among young men in my opinion. Remember in the old days all this weight training and excersize would be like manual labour! Dont do HIT style weight training, that has screwed up many young men, its may work for some but the majority suffer from it so avoid it is best advice.

11.Control mental and emotional stress - this deplets adrenals, cause low testosterone through high cortisol. 'dont sweat the small stuff, its all small stuff'. Try and detach yourself from situations that rouse you emotionally and train yourself to not let things get to you. It will lead to a happier and healthier life.

12.Conduct regular relaxation - do meditation, deep breathing, listen to claming music, whatever allows you to unwind for at least 15 minutes everyday. No matter how busy someone is they can find 15 minutes to relax. If you have the time a nap is even better.

13.Dont have excess sex, only have sex when you are reallly horny. Too much sex is a stressor as well, it taxes internal glands organs. Allow yourself to fel the hunger before you enagage - and by that i dont mean the hunger that arises when you become stimulated, it means the internal needs for release that builds up naturally and you feel the need to release. Everyone can get stimulated and build this hunger, this is wrong so dont look at too much porn. It stressors the glands which imo leads to problems.


These simple rules will allow you to live in modern society and retain good helath, hormone levels and live a healthy and happy life. Its not difficult to do either.

These are valid points but how do you actually expect anyone to live their lives this way? That will bring no joy to anyones life. It eliminates almost all social interaction and fun. It almost makes life not worth living in the first place. I have tried this and it literally made me socially withdrawn and miserable.

 

[hardasnails1973]

Re: Environmental Factors and Low T

These are valid points but how do you actually expect anyone to live their lives this way? That will bring no joy to anyones life. It eliminates almost all social interaction and fun. It almost makes life not worth living in the first place. I have tried this and it literally made me socially withdrawn and miserable.

I have patients that have actually stressed them self out because they live in a glass bubble and take everything on the internet so seriously. It has even hampered one person to the point where they can not even more forward in their life. I basically explained to them they became their own prisoner,

 

[liftermo]

Re: Environmental Factors and Low T

This is not a glass bubble, it is lifestyle adjustment that is necessary because if you dont do it you will be unhappier later on when your health screws up. Its a healthy lifestyle.

However you just do your best and dont worry or fret if you 'fall of the waggon' so to speak, as long as you head in the right direction all is good.

Thats my take anyway, i have started encorporating these steps into my life from a few days ago and will see.

HANS i will do this routine of mine for a couple of months and if i do not get better i will consult you. I am confident just these adjustments alone may bring me back to nomrlaity. I have given up on cafifene and I will also take indolplex DIM as my estradiol was high. Hopefully adrenals will start helaing and estradiol will start lowering due to liver cleansing and use of indolplex.

What do you think?

 

[bax]

Re: Environmental Factors and Low T

so basically live a perfect life in a totally phuked up world!!!

Its not diffiuclt. it just requires organisation.

Let em give an example.

1.Distill your water in the evenings - get the waterwise distiller, set it on and let it do its job. Thats your water taken care of.

2.Try and buy organic, it does not cost that much more anymore, organic is quite accessible. If you cant get orgainc, just do the fruit and veg clean as advocated by the juiceman - Juice of half a lemon and a couple of table spoons of salt, fill the sink tub up and allow veg and fruit to soak for 15 minutes. Clean, drain and store away.

3.Use metalic water bottles, avoid plastic storage, avoid plastic as much as possible.

4.Eat some of the following everyday - broccoli, broccoli, cabbage sporuts, kale etc alternating everyday if you want to balance. Make sure you cook the goitergenic ones though

5.Do a liver cleanse, regularly, the hulda clarke liver cleanse is good. This helps your body get rid of excess estrogens.

6.Avoid all drugs, cigarettes, alcohol and even prescription drugs as best you can.

7.Avoid additives, chemicals, preservatives the best you can

8.Eat simple foods, in their most natural state as much as you can.

9.Go to bed early and wake up refreshed naturally, try and sleep as much as your body needs everyday. Do your best.

10.Avoid microwaves, mobile phones as much as posisble and anything high tech and modern.

10. Control physical stress - dont excersize beyond your means - excersize drives up cortisol - recovery, rest and relaxation is very important. Infact many people become hypogonadal through excess weight training, cardio training etc. Training too much and too hard is the single most cause for hormone issues among young men in my opinion. Remember in the old days all this weight training and excersize would be like manual labour! Dont do HIT style weight training, that has screwed up many young men, its may work for some but the majority suffer from it so avoid it is best advice.

11.Control mental and emotional stress - this deplets adrenals, cause low testosterone through high cortisol. 'dont sweat the small stuff, its all small stuff'. Try and detach yourself from situations that rouse you emotionally and train yourself to not let things get to you. It will lead to a happier and healthier life.

12.Conduct regular relaxation - do meditation, deep breathing, listen to claming music, whatever allows you to unwind for at least 15 minutes everyday. No matter how busy someone is they can find 15 minutes to relax. If you have the time a nap is even better.

13.Dont have excess sex, only have sex when you are reallly horny. Too much sex is a stressor as well, it taxes internal glands organs. Allow yourself to fel the hunger before you enagage - and by that i dont mean the hunger that arises when you become stimulated, it means the internal needs for release that builds up naturally and you feel the need to release. Everyone can get stimulated and build this hunger, this is wrong so dont look at too much porn. It stressors the glands which imo leads to problems.


These simple rules will allow you to live in modern society and retain good helath, hormone levels and live a healthy and happy life. Its not difficult to do either.

All The earmarks of an early Muscleman post........

 

[liftermo]

Re: Environmental Factors and Low T

I have done a lot of research, lots of reading. Muscleman post???

 

[Crazy Crew]

Is Food Packaging Affecting Your Health?

Chemicals like Bisphenol A (BPA), phthalates and PCV (polyvinyl chloride) have all been found in plastic food packaging, the linings of soda cans and canned food. These chemicals, often referred to as endocrine disruptors, do much more than simply help to protect and contain our food. They can mimic our natural hormones, turning on or off the body's native hormone signals to block natural responses or trigger excessive action.




From baby bottles and toys to the lining of milk cartons, it may seem like plastic is everywhere and there this no way to reduce your exposure. But a recent study -- though small -- offers an opportunity for us to be hopeful and puts the power in our own hands. The researchers looked at levels of BPA and bis(2-ethylhexyl) phthalate (DEHP) in individuals who were eating canned and packaged foods and drinking out of plastic water bottles. They were told to eat their normal diet and then were given fresh foods for three days that didn't come from cans or plastic. The researchers made sure the fresh food wasn't cooked or prepared in plastic or stirred with plastic utensils.



In just three days, the participants reduced their levels of BPA and DEHP by more than 50 percent!

Marcelle Pick, OB-GYN N.P.: Is Food Packaging Affecting Your Health?

 

[Michael Scally MD]

[In a series of articles both in print and online, C&EN takes a broad look at the ongoing bisphenol A story. The following is the cover story. The article provides links to the other stories.]

Bisphenol A
A rift persists between safety assessments of the man-made estrogen mimic
Bisphenol A | Cover Story | Chemical & Engineering News

June 6, 2011
Stephen K. Ritter

Regular exposure to bisphenol A from food, drink, and other sources means that the commodity chemical shows up at low levels in the urine of essentially everyone. That fact has created a lot of concern about how toxic BPA might be. But assessing the risk the chemical poses has turned out to be not so simple.

Primarily employed as a building block to make polymers, BPA has been used in an array of consumer goods since the 1950s. It’s a primary component of polycarbonate hard plastics found in reusable drink containers, DVDs, cell phones, eyeglass lenses, automobile parts, and sports safety equipment. The chemical is also a key component of epoxy resins that provide a protective layer inside food and drink cans. It’s found in dental sealants and in cash-register receipts as well.

That BPA has estrogenic activity—the ability to simulate the activity of the primary female sex hormones—is old news, dating back to about 1930. At one point decades ago, it was even considered for use as an estrogen replacement drug until better mimics were discovered.

More recently, however, hundreds of animal and cell-culture research studies have linked the chemical’s low-level estrogenic activity to obesity, diabetes, attention deficit hyperactivity disorder, reproductive health problems, heart disease, and breast and prostate cancer. Yet BPA’s safety status is in limbo because regulators think that the methods used in many of those studies haven’t been fully validated. Instead, regulators continue to rely more heavily on a few larger-scale industry-funded studies that used older, standardized assays and reported minimal ill effects at human exposure levels.

It would be easy enough to test the effects of BPA directly on people and settle the issue. That’s naturally out of the question because it’s unethical. So although the ubiquitous chemical is known to prompt some harmful effects, it remains just beyond science’s grasp to provide a definitive assessment of BPA’s safety. This confounding situation has led to a vigorous debate about what to do with BPA: ban it, restrict its use, or leave it alone.

As this debate has unfolded, the public has been bombarded with a steady flow of studies, reports, claims, counterclaims, conflicts of interest, lawsuits, and congressional inquiries regarding BPA. Both sides of the debate have been active in promoting their views to the media and the public. And both sides accuse each other of using spin tactics to create uncertainty about BPA, not unlike the socioscientific debates that have unfolded over cigarette smoking and climate change.

 

[Michael Scally MD]

Positive Independent Relationship between Urinary Bisphenol A Levels and Diabetes Mellitus

Bisphenol A (BPA) is a chemical produced in very high volume, with more than 2 million metric tons produced worldwide in 2003. It is used extensively in the manufacture of epoxy resins, polycarbonate plastics, and food and beverage containers, and detectable levels of BPA in urine have been shown to be present in the majority of U.S. adults. BPA has been shown to have estrogenic and thyroid hormone-disrupting effects. Recent evidence, especially from animal studies, suggests that BPA exposure may have a role in weight gain, development of obesity and insulin resistance, and the subsequent development of diabetes mellitus. However, the association between BPA levels and diabetes mellitus in humans is not clear.

Two previous studies have examined the association between urinary BPA levels and diabetes and reported opposing findings—with one study reporting a positive association and the other not detecting an association. However, both of the studies used self-reported diabetes as the outcome; fasting glucose or glycosylated hemoglobin was not used as a criterion in defining diabetes in these studies as recommended by recent guidelines. Studies have shown that, when using self-reported diabetes as opposed to blood glucose measurements, there is likely to be substantial misclassification of diabetes status and this may consequently lead to biased risk associations.

In this context, researchers examined the association between urinary BPA levels and diabetes mellitus in the 2003 to 2008 National Health and Nutritional Examination Survey (NHANES), a representative sample of U.S. adults. In the current report, they had fasting glucose levels as well as glycosylated hemoglobin to define diabetes mellitus according to the latest American Diabetes Association guidelines.

In a large multiethnic, nationally representative sample, they found that increasing serum BPA levels are positively associated with diabetes mellitus. The observed association was found to be independent of confounding factors such as BMI, urinary creatinine, alcohol intake, and serum cholesterol level. This study adds to the emerging evidence of the role of environmental exposure to BPA on cardiometabolic health in humans.


Shankar A, Teppala S. Relationship between Urinary Bisphenol A Levels and Diabetes Mellitus. Journal of Clinical Endocrinology & Metabolism. Relationship between Urinary Bisphenol A Levels and Diabetes Mellitus

Background: Bisphenol A (BPA) is a widely used chemical in the manufacture of polycarbonate plastics and epoxy resins. Recent animal studies have suggested that BPA exposure may have a role in the development of weight gain, insulin resistance, pancreatic endocrine dysfunction, thyroid hormone disruption, and several other mechanisms involved in the development of diabetes. However, few human studies have examined the association between markers of BPA exposure and diabetes mellitus.

Methods: We examined the association between urinary BPA levels and diabetes mellitus in the National Health and Nutritional Examination Survey (NHANES) 2003-2008. Urinary BPA levels were examined in quartiles. The main outcome of interest was diabetes mellitus defined according the latest American Diabetes Association guidelines.

Results: Overall, we observed a positive association between increasing levels of urinary BPA and diabetes mellitus, independent of confounding factors such as age, gender, race/ethnicity, body mass index, and serum cholesterol levels. Compared to quartile 1 (referent), the multivariate-adjusted odds ratio (95% confidence interval) of diabetes associated with quartile 4 was 1.50 (1.05-2.14) (p-trend = 0.03). The association was present among normal-weight as well as overweight and obese subjects.

Conclusions: Urinary BPA levels are found to be associated with diabetes mellitus independent of traditional diabetes risk factors. Future prospective studies are needed to confirm or disprove this finding.

 

[beav7]

This shit is scary.

I gnash my teeth at night and have to wear such a plastic piece which also boxers use. I asked my dentist if the material which is used to make this thing is tested for plasticizers and he says he thinks so.
But I heard that even blood bags in hospital contain harmful substances then why should dental materials be free from them? This really worries me. But if I sleep without it then I gnash with my teeth and this is also no solution on the long run cause some teeth are already pretty damaged.

 

[BBC3]

Really the issue is the potential estrogen competition in males ( I think). So we wind up wasting into fat little bitches, all along thinking we were drinking healthy spring water right>> I have researched further over the years. I dont really want my daughters growing titties at the age of 7 - like many these days. I am certain the reprecussions down the road would be bad.

But YOU HAVE to wonder about the contribution in todays breast cancer rate with mature women!?!?!?

Come to think. Pehaps I'll put my 40 year old wife on a steady diet of water bottles and see if she lathers up better. LOL. But you have to wonder the corrolation of plastic bottles drunk, vs. degree of crazy bitch this month. And further cycle regularity, etc... It would be interesting.

HOWVER WE CAN NOT FAIL TO NOTE THIS APPLIES TO SOFT DRINK - DIET COKE BOTTLES AS WELL. And dont forget pizza boxes recently acknowledged...

I dont know if I was this far with this one before, but the amount of BPA in food grade plastics corrolates with the number on the bottom. Usually denoted as surrounded by a Triangle. (2, 5, etc). So there may even be more to whether you want to wash certain dishes in heat, and not just related to whether they will melt..

DEJAVIOUS !! So maybe I have done this. But this is new. I recently inquired to Kentwood water service with regard to their 5 gal delivery bottles. They stated they print a filled on stamp on every bottle and usually within a week when you get it. I have not checked but once or twice.

A critical point unrecognized would be HOW LONG THE BOTTLE SITS STORED, at what temp, and is their a curve of contamination rate.? Apparently the last thing you want to do is store a shitpile of bottled water in your garage for a year of more and then drink it.!!!

But the long and short is this ( I think). The more RIGID the plastic, the less BPA (as a general). So #2 grade being the safest, should also be the most brittle. The Kentwood guy I spoke with was very knowledgeable and indicated they can only TUNE their plastic so far before the 5 gal jugs would be cracking. He did say that they only run them about 5-8 times and then recycle them. What is involved here who knows?? Perhaps the more brittle (hard) they make the plastic, then the less likely to leach out BPA. Then the brittle becomes the con. So Actually I may have been speculating on the relation of BPA with FDA Food grade ratings....

SO someone correct me if I have something backwards...

 

[BBC3]

Really thought, I dont think that the chemical properties are addressed readily with the public. I think I saw in the past that it is simply a molecular stucture that looks similar to estrogen and therefore is speculated to have interactions in human nature??

I dont think there was any causation or implication that the chemicals are "Coercing" TT to turn into estrogen... RIGHT?? Anyone?

So really I have speculated as of late the true lifespan of estrogens in males, and whether of not they linger longer at receptors, onle certain receptors, how many times they go on to interact with other receptors PRIOR TO ELIMINATION.?? So I wonder what the elimination profile of this Chemical (BPA) actually is? And just how detrimental a drink can be??!! I have speulated on male hormonal abnormalities as a function of ESTROGEN INTERFERENCE more so than an estrgoen based feedback shutdown as a direct. So fine, BPA resembles as estrogen molecule. ( and which one moreso (E1, E2, or E3)??? But just what kind of involvement is it having in male receptors? Is it blockading at potential androgen sites? Is it binding to estrogen receptor at A LONGER THAN NATURAL PLAN, and indeed signalling a one-sided shut down?? For an extended time.

Finally, I wonder what we can do to purge this. My first thoughts are physical activity/exercise??

Anyone?

 

[beav7]

I heard one time that there are many plastics which they could use which do not contain harmful substances but they decided to use the plastic which has harmful crap in it. Not sure if this is true but it wouldn't surprise me if it was.

 

[Michael Scally MD]

Canned Soup Consumption and Urinary Bisphenol A

Consumption of 1 serving of canned soup daily over 5 days was associated with a more than 1000% increase in urinary BPA. Generalizability is limited due to selection of participants from 1 school and testing of a single soup brand; however, generalizability to canned goods with similar BPA content is expected. The increase in urinary BPA concentrations following canned soup consumption is likely a transient peak of yet uncertain duration. The effect of such intermittent elevations in urinary BPA concentration is unknown. The absolute urinary BPA concentrations observed following canned soup consumption are among the most extreme reported in a nonoccupational setting. For comparison, the 95th percentile unadjusted urinary BPA in the 2007-2008 National Health and Examination Survey was 13.0 ?g/L (95% CI, 10.0-15.4 ?g/L). The observed increase in urinary BPA concentrations following canned soup consumption, even if not sustained, may be important, especially in light of available or proposed alternatives to epoxy resins linings for most canned goods.


Carwile JL, Ye X, Zhou X, Calafat AM, Michels KB. Canned Soup Consumption and Urinary Bisphenol A: A Randomized Crossover Trial. JAMA: The Journal of the American Medical Association 2011;306(20):2218-20. Canned Soup Consumption and Urinary Bisphenol A: A Randomized Crossover Trial, November 23/30, 2011, Carwile et al. 306 (20): 2218 — JAMA

 

[BBC3]

So are we noting that it is a product that they line the inside of cans with to keep from rusting, or protect the food from the metal?? I have heard this too. I have also heard its in the inside of soft drink cans...

At least it sounds like its being passed.... But at what cost....

Canned Soup Consumption and Urinary Bisphenol A

Consumption of 1 serving of canned soup daily over 5 days was associated with a more than 1000% increase in urinary BPA. Generalizability is limited due to selection of participants from 1 school and testing of a single soup brand; however, generalizability to canned goods with similar BPA content is expected. The increase in urinary BPA concentrations following canned soup consumption is likely a transient peak of yet uncertain duration. The effect of such intermittent elevations in urinary BPA concentration is unknown. The absolute urinary BPA concentrations observed following canned soup consumption are among the most extreme reported in a nonoccupational setting. For comparison, the 95th percentile unadjusted urinary BPA in the 2007-2008 National Health and Examination Survey was 13.0 ?g/L (95% CI, 10.0-15.4 ?g/L). The observed increase in urinary BPA concentrations following canned soup consumption, even if not sustained, may be important, especially in light of available or proposed alternatives to epoxy resins linings for most canned goods.


Carwile JL, Ye X, Zhou X, Calafat AM, Michels KB. Canned Soup Consumption and Urinary Bisphenol A: A Randomized Crossover Trial. JAMA: The Journal of the American Medical Association 2011;306(20):2218-20. Canned Soup Consumption and Urinary Bisphenol A: A Randomized Crossover Trial, November 23/30, 2011, Carwile et al. 306 (20): 2218 — JAMA

 

[dfein]

I'm wondering whether canned tuna also could have BPA or chinese made containers which leak chemicals into food when microwaved.

 

[BBC3]

I just looked up canning on Wiki. Also BPA, and I can say it looks like they have been working on it somewhat. There is a shitload on BPA now...

Here is an exceprt from canning:

Migration of can components

In canning toxicology, migration is the movement of substances from the can itself into the contents.[8] Potential toxic substances that can migrate are lead, causing lead poisoning, or bisphenol A, a potential endocrine disruptor that is an ingredient in the epoxy commonly used to coat the inner surface of cans.

Here is an excerpt from BPA:

Bisphenol A (BPA) is an organic compound with two phenol functional groups. It is used to make polycarbonate plastic and epoxy resins, along with other applications.

As it has been known to be estrogenic since the mid 1930s, concerns about the use of bisphenol A in consumer products have been regularly reported in the news media since 2008, after several governments issued reports questioning its safety, prompting some retailers to remove products containing it from their shelves. A 2010 report from the United States Food and Drug Administration (FDA) raised further concerns regarding exposure of fetuses, infants and young children.[1] In September 2010, Canada became the first country to declare BPA a toxic substance.[2][3] In the European Union and Canada, BPA use is banned in baby bottles.[4]

MORE (SCARY AS SHIT!!!!)
:
Low-dose exposure in animals



Dose (µg/kg/day)

Effects (measured in studies of mice or rats,
descriptions (in quotes) are from Environmental Working Group)[132][133]

Study Year



0.025

"Permanent changes to genital tract"

2005[134]



0.025

"Changes in breast tissue that predispose cells to hormones and carcinogens"

2005[135]



1

long-term adverse reproductive and carcinogenic effects

2009[88]



2

"increased prostate weight 30%"

1997[136]



2

"lower bodyweight, increase of anogenital distance in both genders, signs of early puberty and longer estrus."

2002[137]



2.4

"Decline in testicular testosterone"

2004[138]



2.5

"Breast cells predisposed to cancer"

2007[139]



10

"Prostate cells more sensitive to hormones and cancer"

2006[140]



10

"Decreased maternal behaviors"

2002[141]



30

"Reversed the normal sex differences in brain structure and behavior"

2003[142]



50

Adverse neurological effects occur in non-human primates

2008[57]



50

Disrupts ovarian development

2009[89]


The current U.S. human exposure limit set by the EPA is 50 µg/kg/day.[143]

[edit] Xenoestrogen

There is evidence that bisphenol A functions as a xenoestrogen by binding strongly to estrogen-related receptor ? (ERR-?).[144] This orphan receptor (endogenous ligand unknown) behaves as a constitutive activator of transcription. BPA seems to bind strongly to ERR-? (dissociation constant = 5.5 nM), but not to the estrogen receptor (ER).[144] BPA binding to ERR-? preserves its basal constitutive activity.[144] It can also protect it from deactivation from the selective estrogen receptor modulator 4-hydroxytamoxifen.[144]

Different expression of ERR-? in different parts of the body may account for variations in bisphenol A effects. For instance, ERR-? has been found in high concentration in the placenta, explaining reports of high bisphenol accumulation in this tissue.[145]

Like I said, The wiki on the BPA is pretty long - check it out....

[ame=http://en.wikipedia.org/wiki/Bisphenol_A]Bisphenol A - Wikipedia, the free encyclopedia[/ame]

 

[LW64]

Might as well pile this on:

BPA's Diabetes Link Strengthened by New Study