To the prevous poster that mentioned the increased risk with cortstrds: Just some Wiki stuff. But it does seem the P-450 is pretty poplular and there appear to be many drugs that increase the effects.....
InteractionsTheophylline, nonsteroidal anti-inflammatory drugs and corticosteroids enhance the toxicity of fluoroquinolones.[62][63][64]
Products containing multivalent cations, such as aluminum- or magnesium-containing antacids and products containing calcium, iron, or zinc, invariably result in marked reduction of oral absorption of fluoroquinolones.[65]
Other drugs that interact with fluoroquinolones include antacids, sucralfate, probenecid, cimetidine, warfarin, antiviral agents, phenytoin, cyclosporine, rifampin, pyrazinamide, and cycloserine.[64]
Many fluoroquinolones, especially ciprofloxacin, inhibit the cytochrome P450 isoform CYP1A2.[66] This inhibition causes an increased level of, for example, antidepressants such as amitriptyline and imipramine, clozapine (an atypical antipsychotic), caffeine, olanzapine (an atypical antipsychotic), ropivacaine (a local anaesthetic), theophylline (a xanthine), and zolmitriptan (a serotonin receptor agonist).[66]
ALL of the quinolone family seem to have some similarities in risks, and yet some illicit extremely different worst case scenarios.
Regarding the increased C. Diff and staph incidence. I could only speculate that this again has to do with the length of the drugs actions, and thus also having a lingering, but still occurring effect of colon/skin. Perhaps just the pure power of the total destruction of these bacteria though is the cause, and there are no "friendlies" left to protect. The effect is stated as "a cellular level DNA disruption". So I guess one should be gobbling yogourt whilst smearing dogshit on their skin every day for a couple month post discontinuation. Really, I do find it interesting that no one fucuses on bacterial REPOPULATION. They kinda do with colon, but why not skin??
Sorry I am getting there... I agree with you that Florine may not have much to do. Just pointing out. Although this IS SIGNIFICANT in the DURATION of the drugs ACTION. I also noted it interesting that they state not to give these antibiotics to heavy Benzo users as the drug will apparently effect the CNS receptors in a way that could cause a good enough blockage of the XANAX receptors to cause immediate sever withdrawal symptoms. So this is the admission. And theres the proof too. So now you know its working on the CNS receptors, which I would assume IS RELATED TO TENDON RUPTURE. My experience is that the receptors were stimulated in an involuntarily contracted kinda way. I would also assume THIS is the reason for the tears of tendons. You can only keep a muscle contracted for so long, VOLUNTARILY. The reason for this is that as it tires, the CNS fails to stimulate it AS A SAFTEY MECHANISM AS WELL. So continued stimulation of a muscle like the achilles would not be good. But this applies throughout the body. The achilles is just a muscle that undergoes MASSIVE LOADS in a shit or get off the pot style... So its sink of swim for that one when it comes to LOAD APPLIED.
But you mentioned some other effects I think. Like skeletal/knee. Not sure now. YOU said Floride has nothing to do but contrair -
Excessive exposure to fluoride causes an arthrtiic bone disease called skeletal fluorosis.
There just happens to be something about the nature of this combination of Floride/Flourine that makes it different. ALL DRUGS are different even by the slightest modification to the molecular structure. One chromisome is the difference from you even being born with eyes, etc. This is a great lie used to service some concepts - that similar molecular design means similar results.. NOT True... The molecular effects to skeletal are described as making bone harder and LESS porous. So this is why only a few breif blasts by the dentist as a youth.
Regardless, Floride's HARNENING EFFECT on teeth, may not necessarily be welcomed on bones throughout the body, and for a life time..... Unfortunately it would seem that short of STEM CELLs or GH applied young enough, any bone damage may be a case of premature aging and only reversible by some high end tricks.
I am done for now. But the point is that while may drugs have a flouride base, it does not mean they are acting like flourides. Also I think that the variance in why some have certain problems taking these drugs is due to DIET, Other Drugs, Or genetic predispositions of certain elemental compositions in the body. Truth be told there is probably enough data out there allready to weed out who is a good candidate and who is not. THIS IS WHERE HAVING SOME $CHANGE$ to be treated by a physician outside normal circles would benefit. I am certain whoever is treating Steve Jobs currently, aint operating by current medical practice guidlines and restrictions.
I am only trying to open some doors for you as I think you may be swimming in CIRCLES OF FURY....
Fluoride has nothing to do with it. There are a shit ton of fluoride drugs that have none of these side effects. There are also a bunch of malaria drugs that are essentially FQs that have many of the same side effects - Lariam is one.
