Fluoroquinolone

Hi,

Seeing as this thread is one of the best I've found on discussion of Fluroquinolone side effects and long term updating of case reports, I wanted to submit my own. FYI, I don't having a history of working out, but I' posting here because the thread is so comprehensive. That said, before my floxing, I'd walk for miles and miles all over NYC, now I can walk about a mile on level ground, but with burning and pain. I'm 33.

Here's an abridged version of my recent reaction:

April 20, 2012 -Prescribed 500mg levaquin for pneumonia. Ask Dr. for a different drug as I vaguely member hearing about side effects. She says all drugs have side effects, I must take this or I'll wind up in the hospital. Stupidly, I do. I pop one pill.
2 hours later -achilles tendons hurt, knees hurt. Over night my vision changes in my left eye, urination delayed (I did not realize vision and urination changes were attributable to the drug, at first - the effects are so systemic and I had a 100+ fever from pneumonia, didn't figure it).
April 21, 2012 -Call doctor - report side effects. They tell me to continue treatment. I take another 500mg levaquin. An hour later side effects increase exponentially - feels like acid being poured down my legs and arms,tendons stiff, knees stiff can't walk well vision change persists.

I go to the ER. They take me of Levaquin.

The next six days - Horrible stiffness in tendons, joint pains, can barely walk, wake up shaking in the middle of the night. Vision returns to normal after day 3.

Here's the strange part - after Day 7 - the symptoms seem to abruptly disappear for the next week. I can walk,I feel loose (I still have after effects of pneumonuia, so I wasn't moving much, but I think I felt better).

May 5 - Two weeks after my initial severe reaction from ingesting two 500mg levaquin, and a week after feeling "better" - it all comes back. Tendon and joint pain all over my body, shoulder, elbows, wrists, fingers, hips, knees, ankles toes,burning feeling down my arms, and legs, muscle spasms under my eye and in my back, increased tinnitus, tingling in y extremities severe cramping in my calf muscles, feeling of dryness in my eyes.

Since early May, my joint and tendon pains have migrated all over my body. I have popping/cracking of the joints. In the last few weeks the musculoskeletalsymptoms have plateaued. They are now concentrated in my knees and ankles and my achilles tendons. However, I have no doubt that if I used my upper body more, that would hurt again too. My cramping has mostly subsided. The tinnitus has reduced somewhat but still flares up. The burning feeling is now concentrated in my knees, ankles, feet and achilles. The arthritis type feeling is mostly limited to my lower extremities, but sometimes comes back in my elbows and wrists.

The scariest thing has been the dry eyes, mouth and skin. In mid-june my eyes became really dry, that persists. Eye drops barely help. I don't want to go on prescription restasis drops. The dry mouth is annoying and my hands are also very dry. I'm really freaking out about the eyes.

For those who had dry eyes - cubbie, krater -how are they now? The "flox report" says this symptom is reserved for a severe reaction so I'm really spooked.

Not counting the first week remission, I don't really know if I've "cycled" as of yet, unless, scarily, this is now me at my "best" and I'll go from here to worse and then back to here. I'm also unnerved because I'm only three months in, and I know, most likely, bad stuff is coming over the next however many months and you've got to give it 6 months to see if you are "severe", "intermediate" "mild"according to the Flox report.

Cubbie, and Krater, and others, I would be very interested to hear how you are doing, now, about 1.5 years out?
 
Hi,

Seeing as this thread is one of the best I've found on discussion of Fluroquinolone side effects and long term updating of case reports, I wanted to submit my own. FYI, I don't having a history of working out, but I' posting here because the thread is so comprehensive. That said, before my floxing, I'd walk for miles and miles all over NYC, now I can walk about a mile on level ground, but with burning and pain. I'm 33.

Here's an abridged version of my recent reaction:

April 20, 2012 -Prescribed 500mg levaquin for pneumonia. Ask Dr. for a different drug as I vaguely member hearing about side effects. She says all drugs have side effects, I must take this or I'll wind up in the hospital. Stupidly, I do. I pop one pill.
2 hours later -achilles tendons hurt, knees hurt. Over night my vision changes in my left eye, urination delayed (I did not realize vision and urination changes were attributable to the drug, at first - the effects are so systemic and I had a 100+ fever from pneumonia, didn't figure it).
April 21, 2012 -Call doctor - report side effects. They tell me to continue treatment. I take another 500mg levaquin. An hour later side effects increase exponentially - feels like acid being poured down my legs and arms,tendons stiff, knees stiff can't walk well vision change persists.

I go to the ER. They take me of Levaquin.

The next six days - Horrible stiffness in tendons, joint pains, can barely walk, wake up shaking in the middle of the night. Vision returns to normal after day 3.

Here's the strange part - after Day 7 - the symptoms seem to abruptly disappear for the next week. I can walk,I feel loose (I still have after effects of pneumonuia, so I wasn't moving much, but I think I felt better).

May 5 - Two weeks after my initial severe reaction from ingesting two 500mg levaquin, and a week after feeling "better" - it all comes back. Tendon and joint pain all over my body, shoulder, elbows, wrists, fingers, hips, knees, ankles toes,burning feeling down my arms, and legs, muscle spasms under my eye and in my back, increased tinnitus, tingling in y extremities severe cramping in my calf muscles, feeling of dryness in my eyes.

Since early May, my joint and tendon pains have migrated all over my body. I have popping/cracking of the joints. In the last few weeks the musculoskeletalsymptoms have plateaued. They are now concentrated in my knees and ankles and my achilles tendons. However, I have no doubt that if I used my upper body more, that would hurt again too. My cramping has mostly subsided. The tinnitus has reduced somewhat but still flares up. The burning feeling is now concentrated in my knees, ankles, feet and achilles. The arthritis type feeling is mostly limited to my lower extremities, but sometimes comes back in my elbows and wrists.

The scariest thing has been the dry eyes, mouth and skin. In mid-june my eyes became really dry, that persists. Eye drops barely help. I don't want to go on prescription restasis drops. The dry mouth is annoying and my hands are also very dry. I'm really freaking out about the eyes.

For those who had dry eyes - cubbie, krater -how are they now? The "flox report" says this symptom is reserved for a severe reaction so I'm really spooked.

Not counting the first week remission, I don't really know if I've "cycled" as of yet, unless, scarily, this is now me at my "best" and I'll go from here to worse and then back to here. I'm also unnerved because I'm only three months in, and I know, most likely, bad stuff is coming over the next however many months and you've got to give it 6 months to see if you are "severe", "intermediate" "mild"according to the Flox report.

Cubbie, and Krater, and others, I would be very interested to hear how you are doing, now, about 1.5 years out?

I think in general as time goes on we as a society are going to have to accept increasing levels of toxicity and side-effects from ABX as we scramble to stay a head of resistant bugs. A growing number of people will have no choice based on the ABX sensitivity of their infection to accept these issues. Amoxicillin is by far one of the safest ABX out there with current dosing guidelines of up to 90mg/kg in children who have multiple ear infection and exposures to amoxicillin. Clindamycin/Augmentin is the next step and is much less well tolerated with increased levels of C. diff. Now we're not just dealing with MRSA but VRSA and so on. The ABX used to treat these are even less well tolerated than clinda/aug.

The best we can do now is Rx the ABX with the best side-effect profile that will get the job done but we are quickly blowing past first line and second line ABX with some infections and it's going to make the future interesting.

Actually a fairly scary time - having to choose between your life or limb and the potential for disability or death from the ABX. We're are going to have to accept the lesser of two evils soon.

JMHO as someone who Rx's a lot of ABX.
 
I get what you're saying, but my case is a little different. I actively asked my Dr. if there was a more benign medication and that I didn't want the FQ. My case of pneumonia could not be heard with a stethoscope and was diagnosed via chest xray.

My Dr never infomred me that other drugs were available including the azythromycin - the z-pac. My dr. never informed me of the black box warning on levaquin. They never tested to see whether my pneumonia was bacterial or viral.

In life or death circumstances, maybe I can see prescribing this poison, but not in the scenario I laid out above. When I asked for information so that I could make an informed choice, I should have been given that info and the choice should have been mine. Too bad, I usually research everything but running a fever on a late friday, I took the pill. THEN, after I reported my side effects, the uneducated dr. told me to take ANOTHER pill - and we know the effects of this are dose dependent. Complete negligence and dereliction of duty, I think.
 
I get what you're saying, but my case is a little different. I actively asked my Dr. if there was a more benign medication and that I didn't want the FQ. My case of pneumonia could not be heard with a stethoscope and was diagnosed via chest xray.

My Dr never infomred me that other drugs were available including the azythromycin - the z-pac. My dr. never informed me of the black box warning on levaquin. They never tested to see whether my pneumonia was bacterial or viral.

In life or death circumstances, maybe I can see prescribing this poison, but not in the scenario I laid out above. When I asked for information so that I could make an informed choice, I should have been given that info and the choice should have been mine. Too bad, I usually research everything but running a fever on a late friday, I took the pill. THEN, after I reported my side effects, the uneducated dr. told me to take ANOTHER pill - and we know the effects of this are dose dependent. Complete negligence and dereliction of duty, I think.

[IThe best we can do now is Rx the ABX with the best side-effect profile that will get the job done....][/I]

Sounds like this is what your doctor failed to do. I see this a lot....doctors Rx something and it's like bringing a bazooka to a tennis match in stead of a tennis racket. It's bad form, it drives resistance and unfortunately is often associated with pressure from sales people.
 
First off, I'm sorry this happened to you.

I'm doing fairly well. Still a lot of joint popping and random tendonitis (little bit in shoulder, knee, achilles) but I can do most things I want. Be patient. Things will (probably) get better as time goes on.

I had/have some eye issues. I am on a different type of contact lens now to help with that. They were REALLY dry in the beginning and now most times I don't notice.

The flox report has some good information but trying to determine where you fall in as "severe/mild/whatever" ain't gonna do much for you. Everyone's different.

There is a good facebook page that a lot of quin sufferers use as a support mechanism. You can search for it if you like.
 
Hi Cubbie,

Thanks for taking the time to provide an update on your situation. I'm glad to hear that you're doing better and I hope a full recovery is in the works for you very soon. This has definitely been the worst time in my life. I marveled at reading some of your earlier posts, as I am where youa re now --researching the journal articles, finding out about the mitochondria/dna damage, trying desperately to find supplements that might help.

I've been taking cocktails of supplements that I thought might help, but I'm thinking about going cold turkey on almost all of them because I've always been sensitive to stuff and I wonder if they could cause their own reactions after a time. I'm taking:

500-650mg time release magnesium malate
Vitamin C 1G
Vitamin B Complex
Fish oil 4G
Probiotic
Vitamin D 1000 iu

an have taken but stopped:
Turmeric
Ginger
COq10 - 100mg
R-Lipoic Acid

considering taking:
Glutathione
Alpha Lipoic Acid
L Carnatine

Im also now getting signs of Diabetes Insipidus - my urine is clear, not straw colored no matter now little I drink. The Flox Report says this is a common smptom of severe cases (yikes). I'm thinking it coul also b attributable to the VItamin D as I've read. I'm low in D but I may stop.

Cubbie, and others who were floxed, in general, is the consensus that there really isn't any suppleent that does anything for this?

I'm partial to continued Magnesium supplementation, but not sure.

I'm hoping, praying that this won't get worse and will get better. Thanks again for the update.
 
Hi Cubbie,

Thanks for taking the time to provide an update on your situation. I'm glad to hear that you're doing better and I hope a full recovery is in the works for you very soon. This has definitely been the worst time in my life. I marveled at reading some of your earlier posts, as I am where youa re now --researching the journal articles, finding out about the mitochondria/dna damage, trying desperately to find supplements that might help.

I've been taking cocktails of supplements that I thought might help, but I'm thinking about going cold turkey on almost all of them because I've always been sensitive to stuff and I wonder if they could cause their own reactions after a time. I'm taking:

500-650mg time release magnesium malate
Vitamin C 1G
Vitamin B Complex
Fish oil 4G
Probiotic
Vitamin D 1000 iu

an have taken but stopped:
Turmeric
Ginger
COq10 - 100mg
R-Lipoic Acid

considering taking:
Glutathione
Alpha Lipoic Acid
L Carnatine

Im also now getting signs of Diabetes Insipidus - my urine is clear, not straw colored no matter now little I drink. The Flox Report says this is a common smptom of severe cases (yikes). I'm thinking it coul also b attributable to the VItamin D as I've read. I'm low in D but I may stop.

Cubbie, and others who were floxed, in general, is the consensus that there really isn't any suppleent that does anything for this?

I'm partial to continued Magnesium supplementation, but not sure.

I'm hoping, praying that this won't get worse and will get better. Thanks again for the update.

Vitamin D and a multi are the only two constants I take. Everything else kind of rotates. I wouldn't diagnose yourself with diabetes based on your piss color. Check your blood sugar if you are suspicious.
 
CubbieBlue said:
Vitamin D and a multi are the only two constants I take. Everything else kind of rotates. I wouldn't diagnose yourself with diabetes based on your piss color. Check your blood sugar if you are suspicious.

Diabetes insipidus does not = diabetes mellitus. Two totally different diseases.

But you're correct....piss color is hardly diagnostic.
 
Cipro doesn't do anything for prostatitis.
Plus it is the most dangerous quinolone out there now, if you don't take into account tequin, floxin and some other crap that they removed.
Apart from cipro levaquin causes some sides but not even close as bad as cipro.
At one point i was downing 2 different quinolones per day plus clindamycin plus spectromycin to combat prostatitis. The outcome was very low to minimal.
You need really efficient antibiotics (prulifloxacin at least - or sitafloxacin) to treat it and pressure massages and potent herbs that increase blood flow to the gland. And still its not treatable 100%.
It will possibly come back after some time with much harder strains.
Using a single antibiotic like cipro equals development of resistant strains.
Multiple antibiotics are a must for trying to treat. If you have enterococci strains forget about it. Its untreatable. Completely.
If you have staph aureus its like a 50/50 chance.
Chlamydia is also very tough to almost unbeatable since it utilizes 2-3 different paths and carriers in your immune system to evade treatment.
I use sitafloxacin + clindamycin (sitafloxacin=gracevit) lately (directly from Japan) still results are not the best but i am hoping. Plus using state of the art prostate massager squeezing all the stupid infected prostatic fluid out of the gland and damiana to increase blood flow and make sure at least some of the abx is entering the prostate.

Now regarding the side effects you got from cipro, it is due to its high level of fluoride that they remain for so long.
This drug got me a dozen times to the ER first time i used it 5 years ago.
Ended up loosing part of my vision, damaging joints, developed intracranial pressure (still have it) and a myriad of other unbelievable symptoms which had me walk around like a zombie or sleep most of the day after using it.
Offcourse using vitamins and hormones to overcome its effects is a mistake. Since fluoride doesn't get out of your body in anyway. Using NAC and other antioxidant crap like i heard above is only going to delay all progress.
Quit EVERYTHING
ONLY treatment is complete REST/SLEEP
There is nothing in this world that will make you feel better if have been floxed. Only rest. Only sleep. Only avoiding stress. I heard of people getting mass blood transfusions, restoring all possible hormones, trying any drug in the market to combat cipro's sides and the most wicked stuff only to find out that later on their problems returned.
I started having depersonalisation just the day i quit cipro (17 days of use for prostatitis). Body parts would move without me ordering them to. I watched through my eyes everything move around like in 1920 movies. Everything felt moving slowly and creepy in a way. This lasted 2-3 weeks where i stayed home completely frightened shitless. Then came the weird loss of time and speed. Walking felt like running, getting in a cab was like entering a batmobile. 20 miles per/hour felt like 200 for me. I had to get out of the cab since i couldn't bear the stress of the flight!!!.
Then came the worse of all. Stability issues. I couldn't stand still. I had to reach out and hold on to something to walk. I went to the ENR at least 5 times during the 3 month period that this lasted, they wanted to put me on dexamethasone but i said no no thanks since i heard even more horror stories from patients that had taken them post quinolones. Even the doctors where astonished at my inability to walk properly. They said its definately a vestibular damage from the drug and insisted on me staying in the hospital. I left only to come back in a few days. This went on for quite some time and all sorts of experimenting tests was done on me to find out nothing in the end.
My eye problems came 6 months after stopping cipro and whilst i was taking vitamin C and antioxidants. I woke up one day and started seeing strange lights and fires around me, i thought ok thats the end of my retina its a detachment. I went to the hospital and they told me its all in my mind. Still for weeks i saw those fires and lights wherever i looked. Two weeks later i lost peripheral vision completely. All i kept seeing is whats in front of me only. i went for an MRI and MRA later on. Nothing. I thought it was from the intracranial pressure busting my optic nerve. Still nothing like that found.

9 months post cipro i started feeling like my head would explode. I couldn't get out of bed from this extraordinary pain. The pain that someone hits you in the head with an iron boot.
This became worse and worse as each day went on i felt like puking. The more aspirins i took the worst i felt. I went to the ER again, and after a dozen exams they told me that its all in my head. I went to a private lab and had another MRI. and then after that was negative too i convinced them to get me a myelography, i was so sure that my pressure in my brain had either exploded too much or dropped too low and so the headache had became so relentless. Results = nothing.
They told me its all in my head. Offcourse it was. Then i realised that cipro had messed up with all my neurotransmitters. And each stupid vitamin or herb or anytime i was under stress this brought about a new constellation of symptoms. So i cut every single thing i took to recover and just waited. At 12-13 months post drug use i was almost 80-90% better of its sides.
I only have the intracranial pressure that is anoying now, with this stupid sound in my ears all day long.
 
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Is it possible to take a fluroquinolone antibiotic for say 2 weeks and then have joint, muscle and tendon pain for 10 years or more?
 
Han DP, Szabo A. Flashes, Floaters, and Oral Fluoroquinolones. Arch Ophthalmol. Published online September 01, 2012. http://archopht.jamanetwork.com/article.aspx?articleid=1357782

Context: Fluoroquinolones are commonly prescribed classes of antibiotics. Despite numerous case reports of ocular toxicity, a pharmacoepidemiological study of their ocular safety, particularly retinal detachment, has not been performed.

Objective: To examine the association between use of oral fluoroquinolones and the risk of developing a retinal detachment.

Design, Setting, and Patients: Nested case-control study of a cohort of patients in British Columbia, Canada, who had visited an ophthalmologist between January 2000 and December 2007. Retinal detachment cases were defined as a procedure code for retinal repair surgery within 14 days of a physician service code. Ten controls were selected for each case using risk-set sampling, matching on age and the month and year of cohort entry.

Main Outcome Measure: The association between retinal detachment and current, recent, or past use of an oral fluoroquinolone.

Results: From a cohort of 989 591 patients, 4384 cases of retinal detachment and 43 840 controls were identified. Current use of fluoroquinolones was associated with a higher risk of developing a retinal detachment (3.3% of cases vs 0.6% of controls; adjusted rate ratio [ARR], 4.50 [95% CI, 3.56-5.70]). Neither recent use (0.3% of cases vs 0.2% of controls; ARR, 0.92 [95% CI, 0.45-1.87]) nor past use (6.6% of cases vs 6.1% of controls; ARR, 1.03 [95% CI, 0.89-1.19]) was associated with a retinal detachment. The absolute increase in the risk of a retinal detachment was 4 per 10 000 person-years (number needed to harm = 2500 computed for any use of fluoroquinolones). There was no evidence of an association between development of a retinal detachment and ?-lactam antibiotics (ARR, 0.74 [95% CI, 0.35-1.57]) or short-acting ?-agonists (ARR, 0.95 [95% CI, 0.68-1.33]).

Conclusion: Patients taking oral fluoroquinolones were at a higher risk of developing a retinal detachment compared with nonusers, although the absolute risk for this condition was small.
 
Whats that you say. They choked the chicken till they strained some cartilage?:D Sorry, and dont mean to spell check ya, but if yur gonna have a karate kick going, gotta get it right! Errr.. MMMMM.. OOOhh. System malfunction.... WEBSITE ERROR INTERNAL @ Location #0U812.....

Yes I talked to a few lifters that had same issue with the tendons and it matches my symptoms completely. They did injections of chicken cartliege guided by ultra sound deep in the joint and they where fine in 8 weeks. It does not hurt just annoying when I lift. I might try some DMSO on it to see if I can reduce inflammation. I used DMSO back in the day on my shoulders and cleared it up in matter of a few days.
 
Paterson JM, Mamdani MM, Manno M, Juurlink DN. Fluoroquinolone therapy and idiosyncratic acute liver injury: a population-based study. Canadian Medical Association Journal 2012;184(14):1565-70. Fluoroquinolone therapy and idiosyncratic acute liver injury: a population-based study

Background: Although fluoroquinolones are sometimes associated with mild, transient elevations in aminotransferase levels, serious acute liver injury is uncommon. Regulatory warnings have identified moxifloxacin as presenting a particular risk of hepatotoxicity. Thus, we examined the risk of idiosyncratic acute liver injury associated with the use of moxifloxacin relative to other selected antibiotic agents.

Methods: We conducted a population-based, nested, case–control study using health care data from Ontario for the period April 2002 to March 2011. We identified cases as outpatients aged 66 years or older with no history of liver disease, and who were admitted to hospital for acute liver injury within 30 days of receiving a prescription for 1 of 5 broad-spectrum antibiotic agents: moxifloxacin, levofloxacin, ciprofloxacin, cefuroxime axetil or clarithromycin. For each case, we selected up to 10 age- and sex-matched controls from among patients who had received a study antibiotic, but who were not admitted to hospital for acute liver injury. We calculated odds ratios (ORs) to determine the association between admission to hospital and previous exposure to an antibiotic agent, using clarithromycin as the reference.

Results: A total of 144 patients were admitted to hospital for acute liver injury within 30 days of receiving a prescription for one of the identified drugs. Of these patients, 88 (61.1%) died while in hospital. After multivariable adjustment, use of either moxifloxacin (adjusted OR 2.20, 95% confidence interval [CI] 1.21–3.98) or levofloxacin (adjusted OR 1.85, 95% CI 1.01–3.39) was associated with an increase in risk of acute liver injury relative to the use of clarithromycin. We saw no such risk associated with the use of either ciprofloxacin or cefuroxime axetil.

Interpretation: Among older outpatients with no evidence of liver disease, moxifloxacin and levofloxacin were associated with an increased risk of acute liver injury relative to clarithromycin.
 
Well I just read this thread and am now completely freaked out. I started a ten day script of Levofloxacin for a sinus infection thing I got from my two tear (who may be trying to kill me). I usually run 30+ miles per week. Saturday I felt up for a walk so I managed a slow mile and a half stroll and woke up with super sore calves. I thought I'd look into the rumours Iheard about these Flourodine (sp?) antibiotics, found this thread, and now... well I'm friggin' wiggin'.

I'm going to call my doc and see if I can switch to augmentin (which is supposed to be OK for your ligaments). I've been blowin green boogers for over two months but I don't want to sacrifice my achilles for a quick fix.

I'm curious...

1.) Is the damage done? I mean, how long will this stay in my system?
2.) Can I do anything to flush this out?
3.) Any supplements, etc. that may help?

I'm a semi competitive runner and I've been plagued with achilles/calves issues for a while (now I may know why).

Gents please weigh in.
 
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