MESO-Rx
Anabolic Steroids
Giant Semaglutide Thread (and other GLP-1 / GIP agonists)
- Thread starter Doodle
- Start date
Orc419
Member
Any experienced people know that if after a 3 month break from sema would you be able to start from the same minimum effective dose as your first cycle? In other words, would your tolerance reset? This stuff is absolutely amazing but expensive I'm worried about breaking the bank to maintain my goal weight.
Rido
Subscriber
I cant say I am very surprised. 2 drugs that are known to have nausea effects.
I hope she feels better
SpicyMeatball
Member
The 7.2 study is in phase 3 and set to go for a full year for participants, so has already gotten through smaller studies. Given that combined with the really good safety profile of 2.4mg, I am feeling ok dosing up to 4 or 5mg if needed.
Reverso007
New Member
Hey guys, anyone tried both liraglutide and semaglutide or Tirz? Which one would you guys say is better for appetite suppression and less chance of nausea?
Currently taking 1.2mg of saxenda (liraglutide) on a -700kcal deficit but still crave food so much. Albeit it is stuff like chicken and rice or lean meats, I’m still feeling hungry.
For some reason it’s only helping just a little bit, but for the price doesn’t seem justified (50 quid a month). Notice similar appetite suppression (with no nausea and more energy) with my EC stack.
But obviously I want to see if sema or even tirz have more of an appetite blunting effect without the nausea.
At 1.2 lira -> no nausea, feel full after meals but shortly later am hungry again
At 1.4 lira -> nausea, fatigue, skipping workouts, skipping cardio
EC stack -> energy, happy, can stick to deficit, however increases resting heart rate and blood pressure. Harder to fall asleep.
Current stats: 173cm, 62kg (got a small frame), 13-15% bf trying to get down to 8%.
All suggestions welcome in the GLP1 realm.
And yes I’ve combined lira with EC but very similar to a full doses EC stack suppression wise.
Currently taking 1.2mg of saxenda (liraglutide) on a -700kcal deficit but still crave food so much. Albeit it is stuff like chicken and rice or lean meats, I’m still feeling hungry.
For some reason it’s only helping just a little bit, but for the price doesn’t seem justified (50 quid a month). Notice similar appetite suppression (with no nausea and more energy) with my EC stack.
But obviously I want to see if sema or even tirz have more of an appetite blunting effect without the nausea.
At 1.2 lira -> no nausea, feel full after meals but shortly later am hungry again
At 1.4 lira -> nausea, fatigue, skipping workouts, skipping cardio
EC stack -> energy, happy, can stick to deficit, however increases resting heart rate and blood pressure. Harder to fall asleep.
Current stats: 173cm, 62kg (got a small frame), 13-15% bf trying to get down to 8%.
All suggestions welcome in the GLP1 realm.
And yes I’ve combined lira with EC but very similar to a full doses EC stack suppression wise.
Reverso007
New Member
Just saw this, same experience with me, I posted up above, did you ever end up trying Tirz?
HB_22
Well-known Member
Keep in mind that you have to come off of it at some point and the hunger will come back and fuk you up the higher the dose. Now, I went as high as 1mg and came off and I went as high as 2mg and came off and the last time was for sure harder to manage. I cant imagine going up to 7.2mg and then coming off completely.
But it's actually great to see that we are capable to creat modern drugs like GLP-1 receptor agonists that are kinda safe and also very helpful. At 7.2mg I think the hba1c of most diabetics will be in a healthy range below 5.6.
Reverso007
New Member
Nope, just short and have low bone density. Get this a lot though rip
Deadp007
Well-known Member
Isn't 3.2 mg the clinical dose for liraglutide?
freddy4play
New Member
I don't have a lot to add, but I just want to thank everyone for all the posts over the years. Looking to lose 125 pounds or so to get back to a healthy weight and this forum has helped out quite a bit. Read the whole thing 
I can't bring a whole lot to the table, but I was considering getting a lab freezer to keep tz in, so I could keep it really cold to avoid degradation. (dry) I read some stuff about freezer defrosting that might affect quality. My relative has been an appliance repairman for almost 35 years, so I asked him about the differences. Well, he told me to just keep it in my chest freezer vs refrigerator freezer. I guess most chest freezers don't have auto defrost. He also said that if I was really worried about it, a simple insulated container would keep it at a steady temperature in the freezer. Putting it in the middle of a refrigerator freezer would keep it at the steadiest temperature, even in self-defrost, the temperature barely rises, maybe a degree or two, when it does self-defrost. The self-defrost function normally happens towards the back of the refrigerator, where the most variation would occur. It is designed to go up a minimal amount, because if there is too much variation it leads to frost on your food.
I can't bring a whole lot to the table, but I was considering getting a lab freezer to keep tz in, so I could keep it really cold to avoid degradation. (dry) I read some stuff about freezer defrosting that might affect quality. My relative has been an appliance repairman for almost 35 years, so I asked him about the differences. Well, he told me to just keep it in my chest freezer vs refrigerator freezer. I guess most chest freezers don't have auto defrost. He also said that if I was really worried about it, a simple insulated container would keep it at a steady temperature in the freezer. Putting it in the middle of a refrigerator freezer would keep it at the steadiest temperature, even in self-defrost, the temperature barely rises, maybe a degree or two, when it does self-defrost. The self-defrost function normally happens towards the back of the refrigerator, where the most variation would occur. It is designed to go up a minimal amount, because if there is too much variation it leads to frost on your food.
BigRed91
Well-known Member
Thanks man, but yea she don't get nausea from either one but together she has a near flu like reaction. Puking a few times a day for like 4 days now. I've now read a few other people have had the same kind of reaction.
BigRed91
Well-known Member
Definitely not. Surely she's about over it. Just wanted to let everyone know it's a bad combo
ar7353
Member
I have combined sema and MT2 before and had a shitty reaction, but only the first time I did it. First time I did it, I was puking/heaving for roughly 12 hours, nausea lasted around 48 hours. I will say though, this was a combination of factors.
I was being impatient on titrating the sema and took a higher dose than normal (was also my second dose of the week, as I dose twice weekly). This sema dose was taken in the evening, and then I took my MT2 the next morning before hitting the beach. Was probably only my 3rd or 4th MT2 dose at this point, so I was still evaluating effects. Noticed a few hours later at the beach that I didn’t feel great, could barely eat a quarter of my meal at the restaurant that evening at dinner, and then I was up all night puking and heaving up nothing. Next day I could still hardly eat and felt like ass.
Fast forward to now, a month later, and I have combined them with no issues. I have since taken them on the same day multiple times with no issues at all. I’ve been taking my time with titrating sema like I should have from the beginning, so that helps. Also, I am loving seeing the MT2 effects and have gotten multiple complements recently (thanks Cridi).
I was being impatient on titrating the sema and took a higher dose than normal (was also my second dose of the week, as I dose twice weekly). This sema dose was taken in the evening, and then I took my MT2 the next morning before hitting the beach. Was probably only my 3rd or 4th MT2 dose at this point, so I was still evaluating effects. Noticed a few hours later at the beach that I didn’t feel great, could barely eat a quarter of my meal at the restaurant that evening at dinner, and then I was up all night puking and heaving up nothing. Next day I could still hardly eat and felt like ass.
Fast forward to now, a month later, and I have combined them with no issues. I have since taken them on the same day multiple times with no issues at all. I’ve been taking my time with titrating sema like I should have from the beginning, so that helps. Also, I am loving seeing the MT2 effects and have gotten multiple complements recently (thanks Cridi).
johndoe29434
New Member
Have ran both at the same time for months. Certainly don't dose on the same day. Try to split them. When I ran pharma Id do Sema on a Tuesday and MT2 maintenance dose Sat morning and it was fine. If you do it the same day do the MT2 in the morning and Sema at night. Neasuea on MT2 will hit way faster in my experience than with Sema. With UGL sema doing it 2x a week Ill do Sema - Monday/Friday and MT2 on Wednesdays. Don't have issues but I do run ~350mcg doses of MT2 which is much lower than a lot of people.
BandBob23
New Member
Would start from the lowest dose, and slowly up after 4 day increments until.you get to the dose you lost at to prevent side effects.
Iron_Yuppie
Well-known Member
Pfizer has their own GLP-1, in oral form, in phase 2 and announced yesterday that it achieved the same results as semaglutide in half the time. This whole market is going to be astonishingly huge.
Danuglipron for Glycemic Control Among Patients With Type 2 Diabetes
This randomized clinical trial investigates the efficacy, safety, and tolerability of danuglipron treatment for 16 weeks in adults with type 2 diabetes and inadequate glycemic control on diet and exercise, with or without the use of metformin.
jamanetwork.com
Pfizer's diabetes drug results in similar weight loss levels as Novo's Ozempic
Pfizer Inc's diabetes drug resulted in weight loss similar to that of Novo Nordisk's Ozempic in a mid-stage study testing it in patients with type 2 diabetes, according to data published in a medical journal.
Something as effective as semaglutide in pill form would be a huge success
HB_22
Well-known Member
For the majority of people who don't like to inject for sure, but let's see the market price first. There already is an oral GLP-1 product and it is very expensive compared to injectable forms.Danuglipron for Glycemic Control Among Patients With Type 2 Diabetes
This randomized clinical trial investigates the efficacy, safety, and tolerability of danuglipron treatment for 16 weeks in adults with type 2 diabetes and inadequate glycemic control on diet and exercise, with or without the use of metformin.
Pfizer's diabetes drug results in similar weight loss levels as Novo's Ozempic
Pfizer Inc's diabetes drug resulted in weight loss similar to that of Novo Nordisk's Ozempic in a mid-stage study testing it in patients with type 2 diabetes, according to data published in a medical journal.www.reuters.com
Something as effective as semaglutide in pill form would be a huge success
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