MESO-Rx
Anabolic Steroids
Giant Semaglutide Thread (and other GLP-1 / GIP agonists)
- Thread starter Doodle
- Start date
Don’t forget why you use semaglutide. It is to control homeostatic feeding. Hypothalamus will suppress satiety and increase ghrelin. If in a fast (too low on calorie restriction) it will go into protect mode.
I've been taking 60mcg per day bumped up from 40mcg per day qsc sema doing the job for me don't have cravings so I'm well able to diet
No sides at the moment I'm eating around 1800 cals a day and it's more than enough this stuff is great I would be starving eating 1800 cals a day 180 p rest carbs and fat
No sides at the moment I'm eating around 1800 cals a day and it's more than enough this stuff is great I would be starving eating 1800 cals a day 180 p rest carbs and fat
We haven’t started using tirzepitide yet here in clinic Sema and lira mainly. We will be starting this month. We have been speaking to diabetes colleagues familiar with roll out in US. I am doing a bit more research and figured this would be a great place to look as you guys share the lived experience and are very focused on overall physical results.
LeroyJenkins
Member
Anyone start with a lower dose of tirz than the recommended 2.5mg?
Observations after using Semaglutide and Tirzepatide for the past couple of years. Keep in mind that this is just how my body reacted and these drugs can show massively different effects on people. I’ve done multiple multi month cycles of both of these over the past 3 years. Pharma and UGL.
1 Tirzepatide is the clearly superior drug in terms of how it feels, side effects, results. Semaglutide is like a punch in the gut where you really feel the stomach effects like you can’t eat even if you wanted too like you ate cement where as tirzepatide you just aren’t hungry.
2 there’s something more to these drugs that it easing or potentiating fat loss above and beyond just calorie restriction. I lose more weight on the same calories while on sema and then even more on tirz.
3 the dosages should be stepped up in far smaller steps than what is prescribed now. Pharma dosages are based on mean experiences so they suggest a dose protocol that is good for the average person. I think for example tirz should be started at 1mg a week and people should go up in 1mg increments only when they feel like the dosage is not working as well. This last tirzepatide cycle I had the same results after a few months of 1mg increases vs previously doing the pharma suggested 2.5 to 5 to 10.
4 there’s no difference between pharma and UGL in how the drugs work.
6 there is a huge rebound appetite effect
7 my current thinking is that semaglutide should be used as the cruise drug and tirz the diet cycle drug. So something like 20 weeks of a cutting phase using tirz stepping up at 1mg increments every 3-4 weeks followed by cruise until next cut of .5 mg semaglutide. Or something like that.
8 I cannot weight to see how this class of drugs evolves via research over the next 10 years. If you look at the material improvement between sema and tirz in just 2 years the way this class of drugs should evolve over the next 10 will be astounding I think.
9 at some point we need to get a better understanding of why these drugs behave so massively different in people. Its almost at the level of response differences we see in moonshot cancer drugs
That’s it. Again. This is based solely on my experience.
1 Tirzepatide is the clearly superior drug in terms of how it feels, side effects, results. Semaglutide is like a punch in the gut where you really feel the stomach effects like you can’t eat even if you wanted too like you ate cement where as tirzepatide you just aren’t hungry.
2 there’s something more to these drugs that it easing or potentiating fat loss above and beyond just calorie restriction. I lose more weight on the same calories while on sema and then even more on tirz.
3 the dosages should be stepped up in far smaller steps than what is prescribed now. Pharma dosages are based on mean experiences so they suggest a dose protocol that is good for the average person. I think for example tirz should be started at 1mg a week and people should go up in 1mg increments only when they feel like the dosage is not working as well. This last tirzepatide cycle I had the same results after a few months of 1mg increases vs previously doing the pharma suggested 2.5 to 5 to 10.
4 there’s no difference between pharma and UGL in how the drugs work.
6 there is a huge rebound appetite effect
7 my current thinking is that semaglutide should be used as the cruise drug and tirz the diet cycle drug. So something like 20 weeks of a cutting phase using tirz stepping up at 1mg increments every 3-4 weeks followed by cruise until next cut of .5 mg semaglutide. Or something like that.
8 I cannot weight to see how this class of drugs evolves via research over the next 10 years. If you look at the material improvement between sema and tirz in just 2 years the way this class of drugs should evolve over the next 10 will be astounding I think.
9 at some point we need to get a better understanding of why these drugs behave so massively different in people. Its almost at the level of response differences we see in moonshot cancer drugs
That’s it. Again. This is based solely on my experience.
LeroyJenkins
Member
Nice write-up. Thanks for that. I've been on sema for a almost 2 months and have never needed to go beyond 1mg every 5 days. I just picked up a couple kits of tirz to see how I respond.
I think I'll try 1mg to start, as you've suggested. It'd be nice to be able to make it go a little further, given the price.
Wrote this half asleep on the train this morning so apologies for my poor grammar and spelling
Just wanted to add that I think the next big breakthrough will be an oral version of these that exhibit the same efficacy.
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How fat are you when you used it? Did you do it on a contest prep setting? What's the range and rate of loss on what dose was it optimal, can you elaborate on your protocol and results?
We're you able to keep the weight off, it is well appreciated when you give advice to partner it with results and experience on the process you went through.
I am trying to emulate how a doctor who is also a pro utilize semaglutide on his clients, to suppress appetite on the end of their cut. The main goal is to keep the massive cravings when you're already deep into cutting.
I am due for a diet break and wanted to make the transition to eating on a maintenance as smooth as possible, and being on my fifth month of my cut the calories are on the lowest side, thus I'm employing it at the end when I think it will help me the most.
So, are you saying it's useless when you are already in a very low hypocaloric state? Any studies or experience on this?
I’ve been using both for a couple years now too with little breaks in between. Sema was great at first but lost effectiveness earlier and actually has some uncomfortable sides.
Tirz is fantastic but I notice I have to bump up dosage often now. Can’t wait to try this new Retro stuff coming out. Hopefully it’s affordable like the others.
Fair criticism. At work but will try to respond with more detail later.
mchammertime
Member
Great insight , I found when I microdose the nausea is at minimal, as I inject Hgh twice a day I mix it in my shots, so it’s almost like super microdosing
ThinkDeroid
Banned
I am using Semaglutide since 8 weeks and I don't have any of those "stomach effects". It is just smooth, not hungry, no cravings on hard calorie deficit and even a small meal is enough to be full for half the day.
Tomlikebeetroot
New Member
Happy to share my own results via pm if you like?
I experienced a higher % of muscle loss on ozempic, and switched to tirz when the shortages started.
Tomlikebeetroot
New Member
Weight loss for me didn’t really start until I hit 1.5mg dose
I will administer it 1 mg every 5 days and increase as needed.
Fixingrocks
New Member
If I were starting over I absolutely would start at a lower dose. Even now, I'm at a pretty high dose, but I split it and take half dose every 4 days.
Aren't these drugs tricking your body into assuming that it is fed, therefore your resting metabolic rate stays normal, while in calorie restricted state it would slow down.
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