Giant Semaglutide Thread (and other GLP-1 / GIP agonists)

[Doodle]

Wanted to create a thread where everyone can post their experiences with different sourced Semaglutide.

Who are you using?
Pharma vs non?
Dosage?
How long have you been taking it?
What are your thoughts?
Have you lost weight?
Side effects?
Oral vs injection?
Tests?

 

[clearheaded]

LoL. This is not True!

Researchers have been toying around this class of drugs for years.
A few "-tides" have fallen by the wayside. In 10-15 years there may be other "tides" e.g IBI-362 and BI 456906 that may make us do away with with sema. There are even newer drugs targeting appetite suppression of those blocking glucose absorption from the GIT.
While I agree with you that you can never be sure about anything, that applies for every single medication we have had in the past 30 years. I wouldn't get too worried about unknown severe long term consequences, especially with a medication people took daily for years.

That it worsens kidney function in people with chronic renal failure is just that. It has been observed in a few people, and because it is a new drug, doctors will err on the side of caution for those groups of patients. I know 2 of such cases were women in their 80s so there might not be too much to garner from that. SEMA itself is shown to improve kidney function by ameliorating conditions that lead to renal failure and also reducing microalbuminuria. So, it helps in the early stage but is worse in the latter stages.

All this tells us to do, is to be vigilant. Long term Ibuprofen use for example increases risk of death for women with endometrial cancer, yet improves rates of survival in those with certain types of lung cancer. What do we make of ibuprofen consumption then?

IF we are concerned about abuse, fine. but the narrative of 'unworthy' use of medication needs to take a backseat. Minoxidil's most popular usage today was a side effect in its clinical trial; same goes for viagra. When studs with a weak one pop blu-chew, do we really scream "that is associated with an 11% risk of melanoma?"

I was speaking specifically about reta ie untested not FDA approved etc. as works differently and we really no idea what it may cause, esp in 5 -10 years...

and yes what I said was true was taken directly from the cited article a person posted trying to prove me wrong... AGAIN, people pick a single sentence and dont read what authors actually said which is we dont know and still very possible. now apply that to a drug not even done phase 3....

 

[DanishPanther]

I found this one interesting:
Tirzepatide Reduces Appetite, Energy Intake, and Fat Mass in People With Type 2 Diabetes

There is a lot of speculation and "I feel" this and that conclusion about Sema and Tirz, when it comes to how well it suppresses appetite.

As anyone who knows anything about meds, you can never compare two different meds mg to mg (that's first year 101 in any medicine class), you compare the effects and side effects at the optimal titrated doses.

Etc. You titrate Sema to 2,4 mg and Tirz to 15mg, to compare the two.

Just as you can imagine comparing 1mg Sema to 5mg, or 1,7 mg Sema with 10 mg Tirz.

Here the conclusions are clear:

Appetite scores and energy intake reductions did not differ between tirzepatide and semaglutide.

I can't wait to get some of these studies on Reta as well, many reports say we have to go 8 mg to notice any appetite suppression at all, but then again - it's probably the non-responders that are posting about that.

 

[runway]

Anyone know if they sell Tirz and Sema in turkish pharmacies without prescription? Not really interested in sourcing there since China is probably much cheaper. Just curious.

 

[Captainpotatohead]

15mg tirez taken Sunday - 2.5 days later I have almost zero appetite suppression. Doesn’t make sense - none of the studies on these drugs had participants having to ‘stop’ after using them for X months due to them becoming ineffective. Could it be something to do with the generics I’m using?

 

[roofer22]

15mg tirez taken Sunday - 2.5 days later I have almost zero appetite suppression. Doesn’t make sense - none of the studies on these drugs had participants having to ‘stop’ after using them for X months due to them becoming ineffective. Could it be something to do with the generics I’m using?

My wife takes 2.5 m/w/f to avoid what you're describing. I do the same with sema, albeit different dosage.

 

[DanishPanther]

My wife takes 2.5 m/w/f to avoid what you're describing. I do the same with sema, albeit different dosage.

Yeah, many reports better supression esp with Sema, by splitting it into two doses a week, many have run months and months on 2 x 0.5 m, that way.

 

[Captainpotatohead]

I’ve got some sema on the way so let’s see!

 

[roofer22]

I’ve got some sema on the way so let’s see!

It works but it sucks. I puke a lot. In my experience the cleaner I eat the less puking.

 

[Captainpotatohead]

It works but it sucks. I puke a lot. In my experience the cleaner I eat the less puking.

I’ve used it in the past and don’t recall sides being too bad. I may consider the split doses and do 1mg MWF .. 0.5mg over the max dose but I’m sure it’ll be fine.

 

[DeltsWanted]

It works but it sucks. I puke a lot. In my experience the cleaner I eat the less puking.

You might want to check with your doctor about this- vomiting is a common side effect but it's usually occasional, mostly when upping the dose. Persistent/frequent vomiting is associated with one of the more severe complications that can arise- gastroparesis.

 

[AlexDavis43]

I was speaking specifically about reta ie untested

Retatrutide is not untested.

2023 Rosenstock in The Lancet.

2023 Jastreboff in NEJM.

 

[AlexDavis43]

It works but it sucks. I puke a lot. In my experience the cleaner I eat the less puking.

I’ve used it in the past and don’t recall sides being too bad. I may consider the split doses and do 1mg MWF .. 0.5mg over the max dose but I’m sure it’ll be fine.

You might want to check with your doctor about this- vomiting is a common side effect but it's usually occasional, mostly when upping the dose. Persistent/frequent vomiting is associated with one of the more severe complications that can arise- gastroparesis.

Vomiting is no bueno for sure.

I had to discontinue because of heartburn & GI upset, but never vomited on it. See doc asap. Could be easily avoidable (or not).

May need to switch compounds or dosing protocol.

 

[clearheaded]

Retatrutide is not untested.

2023 Rosenstock in The Lancet.

2023 Jastreboff in NEJM.

yes it has tests but I mean tested for safety in a phase 3 & 4.. not a ~120 people using it for a year but tested looking specifically for safety not if it works at what dosage... ESP as only one with triple action... may be great, may cause some unforeseen problems. time will tell. even with ozempic, every new weightless drug has been a miracle, until it wasn't... thats all im saying. 9/10 times there is no free(or 90% off) lunch. time will tell, looking pretty good, may just be the first miracle since 1920 or whenever they invented insulin in canada!

on a side note, what really sucks for diabetics is people see them as weak shitty people, but go back 150 years they were the ones who could survive hardship, work with no food, go for days out hunting on little food to feed the tribe and their genetics were selected for.. now we give them a 9-5 job in a cubicle or factory with 3 square meals and fucks those great genetics right up.

 

[ShredSeason]

there is no free(or 90% off) lunch

90% off the plate though

 

[ShredSeason]

is it logical a diabetic drug causes hair loss?

It doesn’t, severe caloric restriction causes hair loss. A protocol should be put in place beforehand to prevent this regardless of if the restriction is aided by a GLP.

 

[ShredSeason]

I was thinking more of the money saving aspect of it. Like 2,5 mg every 5 days would be 15 mg per month vs 1,25 mg 2x per week would be 10 mg per month.

China.

Or is it possible to just inject once weekly like only Mondays? Would that be enough? Or do you really get a hunger rebound by day 5?

It is possible, but you really do get a rebound, yes. I’m on Reta, even with the extra day of half life, I notice significant increases in appetite starting day 5. Realistically, your appetite should be nuked enough to make up for any rebound. Unless you’re planning on running a 500 cal deficit or something even smaller, I don’t see this becoming a problem for you.

Also what kind of insulin syringes do you all use? Never done subcutan injections so far.

Buy 31g 5/16” insulin needles.

 

[ShredSeason]

Anyone know if they sell Tirz and Sema in turkish pharmacies without prescription? Not really interested in sourcing there since China is probably much cheaper. Just curious.

My Turkish pharma source is selling Rybelsus (oral Semaglutide), interesting! I wonder what stacking this instead of injectable sema with Tirz or Reta would do, interested to know if anyone has ever tried this.

 

[DanishPanther]

I notice significant increases in appetite starting day 5. Realistically, your appetite should be nuked enough to make up for any rebound. Unless you’re planning on running a 500 cal deficit or something even smaller, I don’t see this becoming a problem for you.

But worth saying that:

1) You are doing a shit load of training on a massive kcal deficit and eating 1/3 of the protein intake you should; meaning your body can't recover at all (read: you are breaking down and killing your body), and therefore it's fighting to make you eat, because your life might very well depend on it.

Even without any drugs, when people die from crash diets its usually because of protein intake either being to low or to bad quality.

2) On top of that you are using the most hunger-stimulating chemicals in existence such as DNP, that at the same time only add to the effect I describe above.

3) And you are running steroids in hunger stimulating levels as well.

4) And taking so many different things, it might be hard to figure out what thing is causing what: or how each thing is effecting each other, some meds might work more and some might work less - it becomes a bit of a mess at that point.

5) Lastly the kicker, according to Lilly themselves and all studies I have seen appetite only really kicks in on Reta around 8mg, but when you hit that spot most report it to suppress as well as Triz, and in the studies, they stay there for years if you do everything else "right", without any sign that it stops working.

So your experience with the med probably won't be useful to anyone else.
It would be interesting if Triz were able to keep your hunger and cravings better at bay under the same conditions though.

 

[ShredSeason]

all studies I have seen appetite only really kicks in on Reta around 8mg

You have zero experience using this or any other GLP. Reta 100% supresses appetite before 8 mg, stop wasting everyone’s time here that’s actually using this stuff and losing weight. You’re the only person here that sits on their ass doing nothing but getting fatter and whining their ass off while lecturing people with 20+ years of bodybuilding experience.

But worth saying that:

1) You are doing a shit load of training on a massive kcal deficit and eating 1/3 of the protein intake you should; meaning your body can't recover at all (read: you are breaking down and killing your body), and therefore it's fighting to make you eat, because your life might very well depend on it.

Even without any drugs, when people die from crash diets its usually because of protein intake either being to low or to bad quality.

2) On top of that you are using the most hunger-stimulating chemicals in existence such as DNP, that at the same time only add to the effect I describe above.

3) And you are running steroids in hunger stimulating levels as well.

4) And taking so many different things, it might be hard to figure out what thing is causing what: or how each thing is effecting each other, some meds might work more and some might work less - it becomes a bit of a mess at that point.

5) Lastly the kicker, according to Lilly themselves and all studies I have seen appetite only really kicks in on Reta around 8mg, but when you hit that spot most report it to suppress as well as Triz, and in the studies, they stay there for years if you do everything else "right", without any sign that it stops working.

So your experience with the med probably won't be useful to anyone else.
It would be interesting if Triz were able to keep your hunger and cravings better at bay under the same conditions though.

I’ve actually been on my GLP for over 2 months, losing weight, changing my life while you’re still reading animal studies wiggling your thumb around your ass while you stuff your mouth with whatever abominations you shovel into it. Hard training was only introduced these last 2 weeks. The entire first month was done with only a GLP and a TRT dose, so I don’t know what the fuck you think you’re onto with this. The half life of these drugs is 5-6 days, and you 100% experience increased hunger towards the end of the week. This has been documented by hundreds, if not thousands of people that use these drugs. Stay in your lane and shut the fuck up on everything you know nothing about.

 

[ShredSeason]

if you really want to lose rapidly, cut the cardio, lower the training volume, and eat at as big a deficit as possible

I can't get my diet clean at the moment, it's against nature laws, simply!

I'm way too heavy, my nervous system is way too tired, stressed and traumatized, I have gut issues, and a constant hunger that going up against feels like having to hold my breath for days, weeks, months, years, I'm in such bad shape that recovering or even walking allot is rough...

- I have been a coach

Clown shit.