Giant Semaglutide Thread (and other GLP-1 / GIP agonists)

[Doodle]

Wanted to create a thread where everyone can post their experiences with different sourced Semaglutide.

Who are you using?
Pharma vs non?
Dosage?
How long have you been taking it?
What are your thoughts?
Have you lost weight?
Side effects?
Oral vs injection?
Tests?

 

[DECLAN]

Unfortunately these clowns have been successfully to a degree. The number of members who DM me rather than post here is an indicator of how effective the intimidation of these idiots that wear their ignorance as a point of pride has been.

They have no interest in "harm reduction" for the people most interested in this thread. They think those in here looking for accurate info on using GLPs for to improve their health, rather than to tweak their appearance the way they do, are "fatty trash", less then them, and deserve nothing but being unhealthy.

The irony is most of these guys are losers by every other real life metric. More likely to be digging out old cesspools or power washing dog shit off decks by the order of some fat guy than leading a company or being top in any field.

You’re going off topic again buddy, the point of these thread is not accommodate your lies and complaints.

This is for sharing actual evidence and information about use of glps, not your drama and personal attacks.

This is OP’s original question, care to share your experiences.

Who are you using?
Pharma vs non?
Dosage?
How long have you been taking it?
What are your thoughts?
Have you lost weight?
Side effects?
Oral vs injection?
Tests?

 

[jonnygira]

I don't see a problem with it. Reta is GLP, GIP so it's "Tirz" with glucagon added. I just wouldn't want to get committed to a compound that's far less cost effective, and still has some questions about what glucagon is going to do long term. It's not even FDA approved yet.

If you think Tirz is out of stock though you should be checking other suppliers. It's widely available.

Not so much OOS - just none in my dose range for domestic warehouse. International will take forever plus the reta is otw. Got a good dose/ frequency of it alone? Also I’m not doing it super long term just don’t want a lapse in my cut here. So thats the protoco I am running with for now

 

[Ghoul]

Not so much OOS - just none in my dose range for domestic warehouse. International will take forever plus the reta is otw. Got a good dose/ frequency of it alone? Also I’m not doing it super long term just don’t want a lapse in my cut here. So thats the protoco I am running with for now

Reta is a superset of Tirz, so it's not like you're going backwards. Just be aware of the consequences of stopping and restarting use. Gear induced liver damage, heart remodeling and arterial plaque accumulation can be slowed, and even reversed by staying on a small maintainance dose below the appetite suppression level. You also avoid the "rebound" effect and most of all, the potential reduction in future efficacy.

 

[jonnygira]

Y

Reta is a superset of Tirz, so it's not like you're going backwards. Just be aware of the consequences of stopping and restarting use. Gear induced liver damage, heart remodeling and arterial plaque accumulation can be slowed, and even reversed by staying on a small maintainance dose below the appetite suppression level. You also avoid the "rebound" effect and most of all, the potential reduction in future efficacy

Yeah last time I used tirz I didn’t even get close to this. Was able to do 2.5/5/7.5mg and it worked amazing. Now I’m like week 3 of 10 and its not the same. So when its over and reta is started I will definitely start small since its first time using. Is 1 or 2.5 mg an ideal starting dose? Also some people do it twice a week versus once, thoughts?

 

[OilCarrier]

Reta is a superset of Tirz, so it's not like you're going backwards. Just be aware of the consequences of stopping and restarting use. Gear induced liver damage, heart remodeling and arterial plaque accumulation can be slowed, and even reversed by staying on a small maintainance dose below the appetite suppression level. You also avoid the "rebound" effect and most of all, the potential reduction in future efficacy.

are there any indications at all for how long these 'downregulations' in efficacy occur?

 

[Grey Spartan]

Also some people do it twice a week versus once, thoughts?

I wonder if there is any science behind micro-dosing a GLP. I saw a few videos by users of the drugs who said more stable levels but no real evidence. If it make the user feel better whether its psychological or actually physical more power to them.

 

[Ghoul]

are there any indications at all for how long these 'downregulations' in efficacy occur?

I'll preface this by saying this is a recognized issue, all protein based drugs have to measure this effect to pass FDA approval. And when those drug neutralizing antibodies are detected they aren't always significant. In other cases they can make the drug completely ineffective.

For semaglutide, about 2% of patients developed antidrug antibodies in the approval trials. No measurement of their impact on efficacy was taken because 2% is within the acceptable standard of users developing ADAs.

I noticed the lessening effect of Sema after a break, personally .Thought the vial was bunk or went bad. Then I noticed other people reporting a similar effect. Later a number of clinicians started reporting the same was happening to their patients in some medical journals.

Finally, in a study of Tirz, researchers noted, coincidentally, that subjects who had been exposed to an early GLP daily injected drug, and stopped using it years earlier, universally had a weaker response to Tirz. So in that case at least, the "immunity" lasted for years, and their immune systems recognized the Tirz and attacked it, clearing it from the body before it could have an effect.

For reasons too complicated to get into, UGL peptides are much more likely to cause antidrug antibodies to form.

Bottom line: We know it happens. It's common enough doctors are warning of its potential, and it could be long term, or like some vaccines, create a lifetime immunity not only to the GLP you're using, but other ones as well. Continued use of whatever the compound is tends to limit this antidrug antibody effect, vs taking a break and restarting. Like getting a vaccine, then a required booster to increase protection against smallpox or whatever, and never needing it again. That "second exposure" strengthens immunity more than a single one can.

Given all the important health benefits this class of meds appear to provide, whether you want to chance losing "access" to them in the future is up to your risk tolerance.

PS. You can at least minimize your risk of developing antidrug antibodies by, in order:

-Dilute sufficiently. Use the dilution rate the manufacturer is using, they need to keep antidrug antibody development to a minimum, so they choose a dilution rate with this in mind.

-Minimize injections. TLDR, subq injections start a chain reaction that kickstarts the immune response, If the manufacturer is using once a week, it's better to use that frequency (or less) and not increase it,

-.22ul filter the reconstituted peptide, This can eliminate the largest aggregates, which disproportionally trigger immune responses. Probobly a step too far for most people, but it does work. Very expensive (think thousands a dose) peptide drugs often require this step before administration.

 

[iris]

@iris, I want to be clear, I don't think you're coming to this debate with ill intent borne out of the same contempt as many of the commenters.

Declan, by far the smartest of the anti-GLP crew, makes compelling, "common sense" arguments that trigger the knuckle draggers who see their visceral "fattie hatred" justified by reasons they could never articulate themselves, to crawl out of the woodwork. His statements about "too good to be true", or "better to avoid pharmaceutical interventions" are actually all good general points that I follow myself, in the absence of evidence to the contrary. I prefer to let a few million other guinea pigs take the lead, since we've seen some awful outcomes from previous "miracle drugs". Drugs that are actually beneficial to be taken indefinitely, instead of being something one should try to use for as short a time as possible are the rare minority.

That's the crux of the matter, however. These aren't some novel "miracle" drugs that just appeared in the last few years. The evidence of safety and benefits is not only substantial, it's overwhelming. By the same standard, ibuprofen is cyanide in comparison. GLPs taken even when not used for weight loss, appear to improve the long term health of nearly every organ and extend life.

It's understandable that most people don't have the time to really dig into this. Some of the worst, most emotionally heated opposition to GLPs came from general practitioner doctors, of all people (mostly very fit ones). Luckily their numbers have been shrinking in the face of so much evidence they look stupid to their colleagues. You can sense the crumbling opposition even here, on Meso. It's far less of a hostile place to GLPs than just 6 months ago.

What's taken the place of the "don't be lazy just eat less move more" narrative is the more nuanced "use it if you must" but just as a "crutch" narrative.

That's the last stand of resistance to the ever clearer science connecting genetics, hormones, and their influence over behavior, in an environment of easily available, often poor quality food to feed this built-in "addiction" as being the root cause of obesity. Not some mass collapse in willpower worldwide that's only avoided by the best people who will themselves to a lower BMI, permanently. Yes of course individual choices play a part. Yes bodybuilders set a great example of the care and discipline that should be taken regarding nutrition, and many other aspects of health the population as a whole should learn from. Not necessarily motivated by health, after all, if a twinkie and ice cream diet led to a great looking body that would be the standard, but nevertheless, good looks and health track pretty closely together. Carefully managed nutrition is seen in those who've been most successful with GLPs, putting it into practice once they don't have to battle with "food noise" every moment of every day. The demand for healthier food by GLP users is changing what people are buying, for those paying attention, and companies are


https://apnews.com/article/wegovy-ozempic-zepbound-obesity-0d2b4e3f055dfd1b02a1d330db805c52

Like I said, I am not and never have denied that hormones play a part in many biological functions, appetite regulation being one.
I'd heard about leptin and ghrelin long before glps.
But I also recognise that we are free to make choices, as sentient beings, who have knowledge and the power to steer decisions independently of other factors.
Whether that works, in the end, is another matter but there must be the recognition that being overweight or ill can also be down to how we choose to conduct ourselves.
We are not solely driven by hormones. We have a brain and choices.

You are an example of that, right?
You have chosen to address your issues in a way that worked and continued along that path, making adjustments, changing your way of doing things, to accommodate your renewed mental and physical health.
We can at least try to rationalise our behaviour, if we want to.
It may not always be possible, but we can try.
Let's agree to disagree on the relevance you and I place on this particular thing.

Declan takes glps for exactly the reasons you have been expounding, to improve health markers and not necessarily for fat loss.
Do you think that, unless these drugs are needed for the purpose they were initially intended (that is, to treat obesity and related conditions), they should be precluded to people who are not in that situation (like Declan)?
Or the many women out there that take them for weightloss despite the fact they do not really need to lose any weight, just to avoid eating? (if eating disorders have always been a problem, for women, I think the availability of this stuff is going to make that even worse. But you may think otherwise).

The half pack of cookies I ate all in one go, mindlessly, yesterday, says I am dickhead, not that my hormones made me do it.
I had the choice to put it down and I did not.
I can eat crap out of boredom, or to cheer myself up.
And then I wonder why there is some fat on my ass, when there was zero.
The same for many other people, whilst for others it may be down to what you say.

So your deployment of

the tongue in cheek sarcasm

Towards others when glps are discussed extends to how they interact with you. Declan responds to your provocations by being a "knuckle dragger", but you are both basically doing the same thing.

Also, why don't you fill the little questionnaire that was at the beginning of the thread and Declan keeps posting?
Are you concerned about disclosing personal info?
You have written about this kind of thing a lot.
Maybe you are unwilling to do it just because of the person who is asking.
But I think the interest is genuine.
Many others have shared it and would be interested in seeing you answering.

OK, it's 11pm and I still have to do a bit of shoulders.
Will see ya when I get back home.

X

 

[iris]

Also, @Ghoul when is this happening?

his 20yr old American Asian gf in Thailand and f her brains out with his 20" python, while burning $100 bills to light up his cigar WHILE scuba diving.

I must give you my TG.
In case there is nothing on tv, where do I sign up for a video call?

 

[narta]

The half pack of cookies I ate all in one go, mindlessly, yesterday, says I am dickhead, not that my hormones made me do it.
I had the choice to put it down and I did not.
I can eat crap out of boredom, or to cheer myself up.
And then I wonder why there is some fat on my ass, when there was zero.

Not you are not a dickhead, you are merely human and once in a while you need to treat yourself.

P.S. Personal opinion: A woman's ass without fat is like having the perfect meat without any seasoning, although great, it's not epic.

 

[iris]

Not you are not a dickhead, you are merely human and once in a while you need to treat yourself.

Thanks for being so charitable, but i did not deserve the treat.

What were you doing up so late, when your dogs bang on your door for walkies, at 5am?
Not eating cookies, of course...

 

[BuildABro]

Thanks for being so charitable, but i did not deserve the treat.

What were you doing up so late, when your dogs bang on your door for walkies, at 5am?
Not eating cookies, of course...

If I had my way I would have no crap food in the house at all, but with a wife who does not give af about fitness and 2 kids ages 5 and 7, the chances of that happening are pretty much nil. They eat one thing for dinner eat night, and I eat another. Daddy's food is "ucky".

I really have tried as hard as I can to instill my nutritional focus on the kids, but it just seems like they would sooner gargle bleach than to eat a vegetable, no matter what technique I use in an attempt to persuade them.

Though in a way I also like seeing the captain crunch, frozen chicken tenders, chef boyardee or whatever in the fridge or pantry. It's a reminder that the vast majority of the rest of the world does not think like I do, and that being around crap does not mean I have to be the weak piece of shit that wallows in it just because it's there. I find it oddly empowering.

 

[Ghoul]

If I had my way I would have no crap food in the house at all, but with a wife who does not give af about fitness and 2 kids ages 5 and 7, the chances of that happening are pretty much nil. They eat one thing for dinner eat night, and I eat another. Daddy's food is "ucky".

I really have tried as hard as I can to instill my nutritional focus on the kids, but it just seems like they would sooner gargle bleach than to eat a vegetable, no matter what technique I use in an attempt to persuade them.

Though in a way I also like seeing the captain crunch, frozen chicken tenders, chef boyardee or whatever in the fridge or pantry. It's a reminder that the vast majority of the rest of the world does not think like I do, and that being around crap does not mean I have to be the weak piece of shit that wallows in it just because it's there. I find it oddly empowering.

Childhood exposure to High Fructose Corn Syrup correlates very closely with adult metabolic diseases like obesity and diabetes.

Introduced into the US food supply in the late 60s, obesity rates started rising a decade later and increased as more foods, from bread to cold cuts started including it. Pics of pre 1970s America showed very few obese people, despite a food abundance.

As it started showing up in food in South America, Europe, and then Asia, obesity rates began to rise the same way as well.

The current theory is that because as we evolved calories were almost always scarce, but fruit would ripen all at once, the intake of liquid sugars (fructose) would suspend normal appetite regulation, by down regulating the sensitivity of GLP and Glucagon receptors, so we'd consume as much as possible during that short period, eating far more than appetite would normally allow. Once that brief ripe fruit period stoped, receptors, and appetite regulation would return to normal.

But like blasting without a break for long enough, eventually, PCT won't be able to restore normal functioning and you have to go on TRT to maintain proper testosterone levels.

Children are now exposed to liquid sugars almost continuously, something unnatural and unique to the last few decades, which may permanently break the system that regulates energy intake, with appetite demanding more calories despite energy needs being met.

Glucose and regular sugar don't seem to cause this problem, they've always been in our diet.

So keeping an eye on ingredient labels for HFCS or Fructose would probably be doing them a big favor.

 

[iris]

I wonder if there is any science behind micro-dosing a GLP. I saw a few videos by users of the drugs who said more stable levels but no real evidence. If it make the user feel better whether its psychological or actually physical more power to them.

Ghouls would say no.
I think this was asked/discussed somewhere else.

 

[iris]

Nearly two decades ago there were a couple of weak, deeply flawed studies that suggest human cognition and the ability to responsibly make decisions doesn't happen until 25.

That until 25, the brain wasn't "fully developed".

These studies were pounced on ideologies and politicians who sought to change many policies, particularly around the age of criminal responsibility (but not the voting age),

That level of selective enthusiasm for "science" that confirms pre-existing ideological positions alone should raise suspicions.

A large number of neuroscientists have since countered this "brain doesn't mature until 25" as patently false, if not outright deceptive.

Perhaps the most glaring flaw, the seminal study on this issue stopped looking at brain changes after 25 (hint: it continues to change at the same pace).

In other words, they chose an arbitrary age, 25, and stopped looking at whether changes continued beyond that age, the. declared at 25 the brain was "fully developed".

Now that I see you here, I forgot to reply to this.
Is this about age of consent?

Then I see this:

At what age are men supposed to stop finding women in their 20s attractive?

Typically hear this kind of backhanded judgement from men for whom a young, attractive partner wouldn't be an option anyway, not you of course. The "consensual" comment and what it suggests is pretty vile, but since such a relationship is so far out of your realm of possibility, it's not surprising you can only imagine it's some sort of coerced, non-consensual slavery.

So you think a man finds a relationship or sex with someone half their age as objectionable just because they can't get some?

 

[Ghoul]

Now that I see you here, I forgot to reply to this.
Is this about age of consent?

Then I see this:



So you think a man finds a relationship or sex with someone half their age as objectionable just because they can't get some?

"Just because" tries to poison the answer before it's even given. Of course it's a factor for some. Like the "He's got a small dick". comments in response to a hot car. You're a woman, you don't find nasty comments borne of envy to be a daily occurance? Come on.

Then there's the echo of Anglo-American puritanism in some. Hypocritical in a million ways I could argue, but it's not a universal set of values, for sure.

The culture of much younger mistresses in France, for example, is perfectly acceptable, even coming with a set of strict rules. Successful Japanese businessmen forming long term committed relationships with Geisha is not some relic of centuries ago.

Now, as women are increasingly gaining significant levels of power and resources, we even see the dynamic in reverse in some of these highly traditional cultures.

A 23 year old woman is not a child, and the ones proclaiming outrage should be more concerned with the common western dynamic of their 18 year old daughters hooking up with 40 close in age guys on Tinder, over the course of a year or two, who quickly discard her, than one in their 20s in a relationship where she's respected, cared for, and as a prerequisite, treated very well,

I'm not concerned with the gauzy, superficial values and judgement of small town America. I dropped my rose colored glasses long ago and operate by my own set.

 

[iris]

"Just because" tries to poison the answer before it's even given. Of course it's a factor for some. Like the "He's got a small dick". comments in response to a hot car. You're a woman, you don't find nasty comments borne of envy to be a daily occurance? Come on.

Then there's the echo of Anglo-American puritanism in some. Hypocritical in a million ways I could argue, but it's not a universal set of values, for sure.

The culture of much younger mistresses in France, for example, is perfectly acceptable, even coming with a set of strict rules. Successful Japanese businessmen forming long term committed relationships with Geisha is not some relic of centuries ago.

Now, as women are increasingly gaining significant levels of power and resources, we even see the dynamic in reverse in some of these highly traditional cultures.

A 23 year old woman is not a child, and the ones proclaiming outrage should be more concerned with the common western dynamic of their 18 year old daughters hooking up with 40 close in age guys on Tinder, over the course of a year or two, who quickly discard her, than one in their 20s in a relationship where she's respected, cared for, and as a prerequisite, treated very well,

I'm not concerned with the gauzy, superficial values and judgement of small town America. I dropped my rose colored glasses long ago and operate by my own set.

Right,
I read above it's a 50 year old and an 18 year old.
I thought it was about that, not you.

 

[Country Club Hero]

Reta is a superset of Tirz, so it's not like you're going backwards. Just be aware of the consequences of stopping and restarting use. Gear induced liver damage, heart remodeling and arterial plaque accumulation can be slowed, and even reversed by staying on a small maintainance dose below the appetite suppression level. You also avoid the "rebound" effect and most of all, the potential reduction in future efficacy.

First I’m hearing about how to come off the stuff. What are the latest recommendations for coming off for a while? I probably have about 2.5 months left on Reta. Then I was planning on taking a few months off and then probably back on Tirz for spring/summer.

 

[Ghoul]

First I’m hearing about how to come off the stuff. What are the latest recommendations for coming off for a while? I probably have about 2.5 months left on Reta. Then I was planning on taking a few months off and then probably back on Tirz for spring/summer.

If you're planning to go back on, I'd really suggest you stay on a low maintainance dose.

There is no tolerance that develops over time. These drugs are designed to be used like insulin for diabetics. Some degree of "immunogenicity", that is, the immune system learning how to quickly attack and remove the compound from your system develops, and when you take an extended break, and come back, it only strengthens this unwanted effect, potentially making it completely ineffective eventually. It may be short lasting, or permanent immunity depending on the specific GLP compound. No one knows, other than Liraglutide, for instance, seems to make you immune to Tirzepatide for years, at least, after stopping.

Sema antidrug antibodies don't affect Tirz, apparently. However, if you develop Sema antibodies, they will attack NATURAL GLP, which helps explain why the "rebound" for some quitters results in them gaining even more weight, as their own GLPs can't suppress appetite as much as they would before. That's a huge risk imo.

By staying on, the body seems to tolerate its presence without increasing its immune response,

There are NO downsides to continuous use, only proven health benefits. You're very modestly supplementing the level of naturally present hormones produced by the digestive system.

This is why I reccomend people consider cost per dose of continuous use when choosing which to use.

If a small dose of Reta is too costly, hopefully Tirz will do the trick, as it's molecule is very close to Reta in shape, I mean 2.5mg Tirz a week is around $2 I think, and it's still enough to keep hitting those GIP receptors in your liver, clearing fat out, and undoing years of scar buildup.

 

[Ghoul]

I wonder if there is any science behind micro-dosing a GLP. I saw a few videos by users of the drugs who said more stable levels but no real evidence. If it make the user feel better whether its psychological or actually physical more power to them.

No, micro dosing, or ANY increase in injection frequency is a mistake.

Each sub-q injection starts a chain reaction that puts your immune system on high alert. This greatly increase the chances, and quantity of antidrug antibodies forming as your body seeks to dispose of this infecting invader,

You always want to minimize the development of antidrug antibodies with any protein based treatment. No one moreso than pharma companies, since you won't buy, and the FDA often won't approve, a drug you quickly develop an immunity to. The observed impact by clinicians and researchers of lessened effects for those who've stopped and restarted strongly supports this is what's happening.