Giant Semaglutide Thread (and other GLP-1 / GIP agonists)

[Doodle]

Wanted to create a thread where everyone can post their experiences with different sourced Semaglutide.

Who are you using?
Pharma vs non?
Dosage?
How long have you been taking it?
What are your thoughts?
Have you lost weight?
Side effects?
Oral vs injection?
Tests?

 

[T&H]

Went up from 0.5 to 0.75 semaglutide and getting bad nausea and constipation a day or two after. Two different nausea meds ain't doing much, but the appetite suppression is there.

 

[clobberingtyme]

Anyone watch Impact Nightline on Hulu where they talk about Ozempic and Mounjaro.

 

[Rido]

Anyone watch Impact Nightline on Hulu where they talk about Ozempic and Mounjaro.

going to now

 

[Fat]

Am I the only one who gets desensitised to Liraglutide/Semaglutide after 12 weeks? How do I prevent this?

 

[Rido]

For those seeking stronger hunger-suppressing effects of GLP-1 agonists, combining it with metformin yields greater results in terms of both hunger suppression and reducing H1AC.

Addition of metformin to exogenous glucagon-like peptide-1 results in increased serum glucagon-like peptide-1 concentrations and greater glucose lowering in type 2 diabetes mellitus - PubMed

Glucagon-like peptide-1 (GLP-1) is an incretin hormone that lowers blood glucose after meals in type 2 diabetes mellitus. The therapeutic potential of GLP-1 in diabetes is limited by rapid inactivation by the enzyme dipeptidylpeptidase-4 (DPP-4). Metformin has been reported to inhibit DPP-4...

pubmed.ncbi.nlm.nih.gov

I really appreciate this. I incorporated metformin to make it cheaper. It definitely works.

I am starting to wonder if hgh is counteracting the hunger inhibition now

 

[Yosyrj]

I really appreciate this. I incorporated metformin to make it cheaper. It definitely works.

I am starting to wonder if hgh is counteracting the hunger inhibition now

One of the reason I stopped hgh was cuz made me insulin resistance after using it for a long time combined w testosterone, I want to go back to do it again now that my glucose is somehow between 85 to 95 average, but concerned also abt hunger coming back, probably adding metformin will help

 

[Rido]

One of the reason I stopped hgh was cuz made me insulin resistance after using it for a long time combined w testosterone, I want to go back to do it again now that my glucose is somehow between 85 to 95 average, but concerned also abt hunger coming back, probably adding metformin will help

I have no idea. My a1c hasn't changed at all. Sits at 5.1. Even on a bulk.

It would still be good on hgh or not

 

[Yosyrj]

I have no idea. My a1c hasn't changed at all. Sits at 5.1. Even on a bulk.

It would still be good on hgh or not

Ideal will be 5 or below, I was able to lower it from 5.5 to 5.1 with lot of cardio and diet, right before GLP I have it at 51 few months ago, I can tell that my numbers will drop to 4.8 in the next 3 months since I’m measuring each morning and is lower than ever and never above 100 anymore

 

[bigtyivier2k2]

do you mean the next dose will be 5mg?

Yeah. Yesterday did my first 5mg. I wonder if Im a non responder. I dont feel any different between 5mg and 2.5mg

 

[bigtyivier2k2]

Dude be very careful what you wish for, last 2 weeks I was like 1 egg, 1 bacon, 1 piece of toast for bfast if I was lucky. I actually ahd nightmares about not being able to gain and going Stephen King Thinner style. I backed way the fuck off of the sema. Now its somewhat normal, but yeah the 2 pieces of sushi and feeling full/sick shit was a bit much

Sema or Mounjaro??
I just did a 5mg Mounjaro shot yesterday and have yet to feel the effects ur talking about

 

[Rido]

Sema or Mounjaro??
I just did a 5mg Mounjaro shot yesterday and have yet to feel the effects ur talking about

You should research peak time of mounjaro

 

[T&H]

Sema or Mounjaro??
I just did a 5mg Mounjaro shot yesterday and have yet to feel the effects ur talking about

Didn't you say you didn't feel the 2.5 for a few days too? And then you began to see it working after.

 

[Fat]

Vigourous Steve recommends 1mg of Mounjaro Monday, Wednesday and Friday instead of 5mg 1x a week.


View: https://youtu.be/ocx076as67c

 

[effswithtren]

Vigourous Steve recommends 1mg of Mounjaro Monday, Wednesday and Friday instead of 5mg 1x a week.


View: https://youtu.be/ocx076as67c

Doing 1mg once a week of sema had me rolling in nausea and heartburn. Splitting it to two .5’s made a world of difference.

 

[Rido]

Doing 1mg once a week of sema had me rolling in nausea and heartburn. Splitting it to two .5’s made a world of difference.

This is tirazepide but I definitely wouldn't like a vigorous Steve video. some of his reccomendations are a little whack

 

[bigtyivier2k2]

Vigourous Steve recommends 1mg of Mounjaro Monday, Wednesday and Friday instead of 5mg 1x a week.


View: https://youtu.be/ocx076as67c

He also recommended 5-amino-1mq and $500 later (from peptide sciences last year) it didnt do shit

 

[Fat]

Doing 1mg once a week of sema had me rolling in nausea and heartburn. Splitting it to two .5’s made a world of difference.

When using pharma grade stuff its hard to adjust the dose with their pens

 

[Rido]

When using pharma grade stuff its hard to adjust the dose with their pens

No it isn't. You transfer it to a vial

 

[Fat]

No it isn't. You transfer it to a vial

Lol! Thanks for that tip

 

[Rido]

Lol! Thanks for that tip

I did it for 2x 10mg injectors today lol