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Giant Semaglutide Thread (and other GLP-1 / GIP agonists)
- Thread starter Doodle
- Start date
HB_22
Well-known Member
Lol. I added 250mg Metformin yesterday evening to my "before bed routine" with my HGH and today I woke up and my stomache is feeling so full, I cant eat and I have a feeling of vomitting, its very managable tho but it's there.
Seems like they potentiate each other, GLP-1s and tiny doses of Metformin for hunger suppression and probably weight loss.
I think 250mg once a day before bed is enough for me, the hunger suppression is really strong.
Seems like they potentiate each other, GLP-1s and tiny doses of Metformin for hunger suppression and probably weight loss.
I think 250mg once a day before bed is enough for me, the hunger suppression is really strong.
vanguardx6
Member
Is it much more than with GLP-1's solo? I found this online
In patients with type 2 diabetes mellitus, metformin inhibits DPP-4 activity and thus increases active GLP-1 concentrations after subcutaneous injection. In combination with GLP-1, metformin significantly lowers plasma glucose concentrations in type 2 diabetes mellitus subjects compared with GLP-1 alone, whereas insulin responses were similar. Metformin enhances serum concentrations of injected active GLP-1(7-36)amide, and the combination results in added glucose-lowering potency.
(Addition of metformin to exogenous glucagon-like peptide-1 results in increased serum glucagon-like peptide-1 concentrations and greater glucose lowering in type 2 diabetes mellitus - PubMed)
In patients with type 2 diabetes mellitus, metformin inhibits DPP-4 activity and thus increases active GLP-1 concentrations after subcutaneous injection. In combination with GLP-1, metformin significantly lowers plasma glucose concentrations in type 2 diabetes mellitus subjects compared with GLP-1 alone, whereas insulin responses were similar. Metformin enhances serum concentrations of injected active GLP-1(7-36)amide, and the combination results in added glucose-lowering potency.
(Addition of metformin to exogenous glucagon-like peptide-1 results in increased serum glucagon-like peptide-1 concentrations and greater glucose lowering in type 2 diabetes mellitus - PubMed)
HB_22
Well-known Member
Well I dont know about the scientific background but my appetite is completely gone. Right now I feel like I could live forever without ever taking a bite of food. I have no craving for water as well, that's something I force myself to cause its really warm here.
Hunger suppression is a lot stronger than with Semaglutide alone.
Hunger suppression is a lot stronger than with Semaglutide alone.
Thank you for this I am super interested in using both. Does this mean the combination of the two is bad for glucose control? Can you explain it to me like I’m 5?
HB_22
Well-known Member
Hm from how I understand the scientific explanation it is more like metformin helps any GLP-1 drug to do its job, leading to higher concentrations of GLP-1 and by that leading to more blood glucose control (stronger bg lowering effect with both, than with GLP-1 alone).
I take 1000mg metformin once a day. With my bigger meal. That seems to work for me.
Yep this is what I'm doing... thinking about combining it with a little low dose semaglutide towards the end of the week when the hunger starts coming back but not sure if there's any risks with mixing the two.
HB_22
Well-known Member
Im mixing them and I have done a loooong google search and couldn't find anything negative about combining two different GLP-1 agonists.
For those using the injectable peptide… shake the reconstituted vial before drawing or just a light swirl like with GH? I have the 5mg semaglutide so I reconstituted in a separate, sterile vial. I’ll be getting the 2mg pucks next time.
but shake or swirl? Is it delicate?
but shake or swirl? Is it delicate?
vanguardx6
Member
I swirled it. Currently on 5mg Tirzepatide. At day 5 i feel the hunger slightly kicking in again so i'm adding .25mg semaglutide on this day. See how that treats me.
I noticed that too. I pin Tuesday and by Friday/saturday I’m standing in my pantry debating a binge! I think I’m going to up the dose and split it to twice a week.
Ya I’m finding the same thing with peptide versions. The Ozempic seems to work fine once a week, I just needed to up the dose quicker and luckily my sides are very minimal and short lived.
HB_22
Well-known Member
Well I even do the Ozempic twice a week. Not sure why but I feel with either the QSC peptide but also with the original Ozempic the effect lasts roughly 4-5 days and then gets weaker.
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