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The table I mentioned compared 95 on semaglutide to 45 placebo. The semaglutide group lost much more fat (8.36 vs 1.37) but also more absolute lean mass (5.26 vs 1.83).
According to that, the % of weight lost that was lean mass was 38%. Now, I’m certain some of the lean mass was water, but no way to know how much for certain.
Oh I’m not claiming that group is an ideal set of people to compare for us. In fact, I’m not even sure if they were on any kind of weight training regimen. If not, then the mere implementation of that would further skew the weight loss to a greater % of fat mass lost. And I’m definitely of the opinion that aas use makes loss of actual muscle (not just water) essentially a non-issue.But none of these were people also on aas I would assume which would basically make that irrelevant to those who are and using semaglutide.
The better question is were these people eating a diet high in protein? Because I know plenty of fat people and they eat a lot but mostly crappy food (high carb, high fat, mostly less or moderate protein). Now imagine these people take semaglutide or tirzepatide and dont have much hunger anymore. But their eating habits still remain the same, they just eat less. So instead of 10 pizzas they eat 2 now and lose a lot of weight. So they still get a lot of carbs and fat in but kinda low protein.But none of these were people also on aas I would assume which would basically make that irrelevant to those who are and using semaglutide.
For a study that doesn't mention weight training or exercise to me that is still ideal. The other group had more lean mass loss than fat loss .The table I mentioned compared 95 on semaglutide to 45 placebo. The semaglutide group lost much more fat (8.36 vs 1.37) but also more absolute lean mass (5.26 vs 1.83).
According to that, the % of weight lost that was lean mass was 38%. Now, I’m certain some of the lean mass was water, but no way to know how much for certain.
Do you ever go hypo on this stuff?For a study that doesn't mention weight training or exercise to me that is still ideal. The other group had more lean mass loss than fat loss .
There is something out there with a group that did exercise that did retain alot of their muscle but I can't find it .
But to me, this is still an improvement of overall body composition. Their bodyfat percentage still went down
the first time I was on metformin on HGH and I started sema. I definitely felt it.Do you ever go hypo on this stuff?
And is there a mechanism that causes the weight loss or is it strictly just the appetite suppression?
Habe you tried once per week dosing for the semaglutide? You should try once per week. I think it's better.
How many carbs are you eating? Do you test your blood sugar? You should test your blood sugar (buy a glucose monitor). If you have very good blood sugar numbers, then I wouldn't take metformin unless you want it for anti aging benefits.
This is the one the Mrs. bought https://www.amazon.com/gp/product/B08G5BZQVL/ref=ppx_yo_dt_b_search_asin_title?ie=UTF8&psc=1 (Amazon.com) it seems to work well.
There seem to be some benefits beyond just the appetite suppression. But yes the vast majority of the weight loss seems due to calorie restriction.Do you ever go hypo on this stuff?
And is there a mechanism that causes the weight loss or is it strictly just the appetite suppression?
Oh, agreed. I guess my message seemed to be implying something negative about the glp-1 drugs. Definitely was not my intent if that's how it came across. When you try to get really unhealthy, sedentary people to lose weight you're taking whatever you can get.For a study that doesn't mention weight training or exercise to me that is still ideal. The other group had more lean mass loss than fat loss .
Agreed. It does seem like a large lean mass loss at first glance, but I would strongly suspect that a great deal of it is water. And I do believe we need to assume they're not weight training and maybe not even exercising at all. So an improvement of nearly 30 pounds lost on average (compared to placebo of 6 pounds) is pretty incredible.There is something out there with a group that did exercise that did retain alot of their muscle but I can't find it .
But to me, this is still an improvement of overall body composition. Their bodyfat percentage still went down
should've used this dosing schedule. I started 0.5 mg Sunday and Wednesday now its Friday night and I have no motivation to do anything lol. Gonna wait till next Wednesday and start back at 0.25 weekly and ramp up slowly. I got plenty of this stuff and not in a hurry I do like the feeling of being full I just didn't realize the effect overdosing would have on dopamine. Good stuff otherwiseHere is my type up for dosing instructions for UGL vials.
Would be nice to have input.
There may be hyperlinks for studies/recommendations for meds. I am not recommending or endorsing any particular source. this is just to help other users.
I have used this on 10 users. 7 of them were women.
Ancillaries to have on hand:
Famotidine - every 12 hours Acid reflux control. https://a.co/d/hdZowI8 (Amazon Brand). Costco also has this for dirt cheap.
I do not advise Proton pump inhibitors(omeprazole, lanosprozole, pantoprozole) as medical data shows us some of the long term issues… Also drug to drug interactions.
Pepto-Bismol- great for sulfur(egg) burps. Might make stool black, if it turns black, it does not mean you have internal bleeding.
Tums - Short term acid reflux control. I prefer https://a.co/d/hxZcPOf (this formulation) of it. Costco brand one gives me a metallic taste I do not like.
Simethicone - great for gas pain/ clearance. little to no toxicity profile. You really cannot OD on this. https://a.co/d/bwM0ZAk (Amazon Brand)
Metformin has been shown to help boost the effects of the weight loss. Unsure of how to incorporate this in. Maybe when the drug stalls out or to make smaller doses more effective. (from Ttran1485)
Addition of metformin to exogenous glucagon-like peptide-1 results in increased serum glucagon-like peptide-1 concentrations and greater glucose lowering in type 2 diabetes mellitus
Laxatives- Keep MiraLAX, senna, or bisacodyl on hand.
General sides with Semaglutide
-Heart burn
-Constipation
-Nausea
-Fatigue(unsure if it’s the calorie deficit causing this)
Some little tips:
This is great to combine for BG control for HGH.
Increase hydration to promote bowel movements
Keep a laxative on hand to make sure you do not get backed up.
Dosing
Jano has done a stability test on the semaglutide and no degradation after 2 weeks in the fridge from QSC vials. I am assuming this applies to all generic. Click here for Jano degradation trial
You do not need to increase the dose if you are unable to tolerate the sides or if the appetite suppression is adequate.
weight loss has been shown to stall around 4 months. Might be ideal to titrate off and take a break for 3-4 months. Or could try to incorporate metformin to make it stronger.
One other alternative to dosing is to dose every 4-5 days(use inject half of target weekly dose). This can help maintain peak drug concentrations. You can also create more subtle increases and titrate on the way you feel
Ozempic(Semaglutide) dosing brochure. Click here
Place 2 ML in the 4mg vial
0.25mg weekly x 4 weeks. (13 units on the syringe)
0.5mg weekly x 4 weeks (25 units)
1mg weekly x 4 weeks (50 units)
1.5mg weekly x 4 weeks (75 units)
2mg weekly x 4 weeks (100 units)
2.4mg weekly ongoing (120 units/1.2ml)
My preferred dosing is used with 1 ml. this is what I have used on other people
0.4mg weekly x 4 weeks(10 units on the syringe)
0.6mg weekly x 4 weeks (15 units on the syringe)
1mg weekly x 4 weeks(25 units on the syringe)
1.5mg weekly x 4 weeks (38 units on the syringe)
2mg weekly x 4 (50 units on the syringe) When I get to this point I mix 2 vials and combine them into 1.
2.4 mg weekly ongoing(60 units on the syringe)
Recomp. Possibly low dose at 0.5mg a week.Does semaglutide have any application when on a gaining phase? Like I wonder if there is a dose where you get the benefits of increased insulin sensitivity without killing hunger?
I will probably only use it during mini cuts however.
I would rather advise for metformin on a bulk
BG control if you are on hghWhat's the benefit of metformin on a bulk? Still researching this one