GLP Non responder's

[Here2Learn]

I’ve been reading studies on GLP’s and found this interesting. Just data points. I read another one saying those who are sicker or had early childhood obesity or trauma had higher rates of non response too.

Quote from study
“Conclusions
A high HbA1c at baseline and previous non-insulin therapy were the main predictors of a greater response (optimal HbA1c and weight response) to GLP1ra in both men and women. This may aid in treatment decision-making before initiating treatment with GLP-1RAs.”

https://www.sciencedirect.com/science/article/abs/pii/S1751991822001711

 

[noteablequotable]

I just got some vials off of Amazon that are covered in glitter. I tried googling if glitter affects peptide aggregation and it’s coming up blank. Am I taking on additional risk by using this, or will I just be more stylish?

seriously though, where am I meant to get proper vials? I’m sending these “vials” back, but where am I meant to get properly made ones?

And thanks, Ghoul, for all the material to read

Would you mind telling us what brand this was so no one else makes the same mistake?

 

[HUGE McBIGLARGE]

Would you mind telling us what brand this was so no one else makes the same mistake?

 

[Ghoul]

How can you tell when the filter is clogged?

I plunge the reconstituted solution through the filter into a new vial, and eventually the filter gives some “pushback”. This isn’t from the vial, as if I try plunging into air it still gives pushback.

I can get water through, but not air. What gives?

Here’s a video after I disconnected the syringe, filled it with air, and tried getting it through the filter


View attachment 300729

What kind of filter material is that?

 

[HUGE McBIGLARGE]

What kind of filter material is that?

Why? These the wrong ones?

Also, is it safe to make BAC water from pharma-grade sterile water (not saline) and mixing it with benzyl alcohol I bought off eBay?

 

[Strongerhope]

I’ve been reading studies on GLP’s and found this interesting. Just data points. I read another one saying those who are sicker or had early childhood obesity or trauma had higher rates of non response too.

Quote from study
“Conclusions
A high HbA1c at baseline and previous non-insulin therapy were the main predictors of a greater response (optimal HbA1c and weight response) to GLP1ra in both men and women. This may aid in treatment decision-making before initiating treatment with GLP-1RAs.”

https://www.sciencedirect.com/science/article/abs/pii/S1751991822001711

Would this mean that being a keto binge eater - would lead to less positive effects w/ glp1s?

 

[Here2Learn]

Would this mean that being a keto binge eater - would lead to less positive effects w/ glp1s?

I don’t think a keto binge eater has a defined increase/decrease of insulin. The study was discussing those coming in with high blood sugar levels and those never treated for insulin deregulation.

 

[Strongerhope]

I don’t think a keto binge eater has a defined increase/decrease of insulin. The study was discussing those coming in with high blood sugar levels and those never treated for insulin deregulation.

Wouldn't a keto binge eater, who say - eat's lbs of fat/protein at a time, in excess calories. EX pork rinds/cheese/meat still maintain lower levels of blood sugar spikes? Or am i misguided?

 

[HB_22]

Maz is better than Reta if what you care about is WL, but otherwise you're right.

Nope, in terms of WL reta can not be beaten.

 

[noteablequotable]

Nope, in terms of WL reta can not be beaten.

I wrote an entire paper about this that pulled in data from multiple studies. You can find it around here somewhere.

 

[HB_22]

I wrote an entire paper about this that pulled in data from multiple studies. You can find it around here somewhere.

Okay point me to the study that is showing retatrutide to not be superior for weight loss / body weight reduction. There is no such study, so whatever you wrote into that paper is utterly nonsense.

 

[noteablequotable]

Okay point me to the study that is showing retatrutide to not be superior for weight loss / body weight reduction. There is no such study, so whatever you wrote into that paper is utterly nonsense.

I knew you'd come back and reply with a low effort comment.

Here is a link to my paper which has 25 citations:
View: https://drive.google.com/file/d/1YbQce6VDrJrQCQuEv4JmiSoVCvI1sKIj/view?usp=drivesdk


If you're going argue without reading or doing additional research I won't reply to you again.

 

[HB_22]

I knew you'd come back and reply with a low effort comment.

Here is a link to my paper which has 25 citations:
View: https://drive.google.com/file/d/1YbQce6VDrJrQCQuEv4JmiSoVCvI1sKIj/view?usp=drivesdk


If you're going argue without reading or doing additional research I won't reply to you again.

I was asking you for the study that you think does point into the direction of showing mazdutide to be superior for weight loss. There is no such study linked in your paper. Answer the simple question and link the study. But there are studies showing mazdutide resulted in less weight loss than retatrutide, now let us know how you come up with the opposite conclusion.

 

[noteablequotable]

I was asking you for the study that you think does point into the direction of showing mazdutide to be superior for weight loss. There is no such study linked in your paper. Answer the simple question and link the study. But there are studies showing mazdutide resulted in less weight loss than retatrutide, now let us know how you come up with the opposite conclusion.

What exactly are you getting out of this exchange?

I too have seen studies showing Mazdutide results in less weight loss than Retatrutide. I have also seen studies showing it results in more. Both types of studies are linked in the paper I shared with you. I even created a nifty table for people who don't like to read, but there is nothing I can do for people who don't want to use their braincells.

I specifically wrote that up in paper form months ago so that it would be easy for others to understand my thinking, refer to specific references, and critique my conclusions where appropriate. You're not interested in any of that so we have nothing to talk about. Please ignore me from here on out.

Since you don't want to read, I suggest you Google the other studies on Mazdutide. Look for info about 9mg, 10mg, and 16mg doses. Bye.

 

[HB_22]

What exactly are you getting out of this exchange?

I too have seen studies showing Mazdutide results in less weight loss than Retatrutide. I have also seen studies showing it results in more. Both types of studies are linked in the paper I shared with you. I even created a nifty table for people who don't like to read, but there is nothing I can do for people who don't want to use their braincells.

I specifically wrote that up in paper form months ago so that it would be easy for others to understand my thinking, refer to specific references, and critique my conclusions where appropriate. You're not interested in any of that so we have nothing to talk about. Please ignore me from here on out.

Since you don't want to read, I suggest you Google the other studies on Mazdutide. Look for info about 9mg, 10mg, and 16mg doses. Bye.

I cant take you serious.There is a reason for why high dose mazdutide is no longer subject of research, it stopped at phase 1b trial, unlike retatrutide which is likely going to complete phase 3. I doubt that we will ever see a 16mg mazdutide study being succesfully completed. Furthermore your own table does not even support your claim as it clearly shows retatrutide to be superior.
So whatever you compare is utterly nonsense.

 

[MackVMT]

Currently on 15mg a week tirz real deal from pharmacy. Not a great responder but responding well at the high dose.
Others I know respond as well as I have at half the dose.

 

[noteablequotable]

I cant take you serious.There is a reason for why high dose mazdutide is no longer subject of research, it stopped at phase 1b trial, unlike retatrutide which is likely going to complete phase 3. I doubt that we will ever see a 16mg mazdutide study being succesfully completed. Furthermore your own table does not even support your claim as it clearly shows retatrutide to be superior.
So whatever you compare is utterly nonsense.

I was actually going to ignore you but now you're just lying and spreading misinformation which isn't okay.

The 16mg Mazdutide study was Phase 1, but research on higher doses wasn't stopped, it was finished. They just presented their findings at a conference this September and concluded that it was as safe as other incretin memetics in their phase 1 trials at that dose. Innovent only bothered to investigate the 16mg dose because back in 2023 they found the 9mg dose safe and effective as well.

As for weight loss, I don't know how you do math, but 24.2% weight loss in 48 weeks is slower than 15.4% in 24 weeks or 20.6% in 20 weeks.

If you happen to be anti-Mazdutide because you're worried about your LLY stock, you should know that Eli Lilly owns the rights to Mazdutide everywhere but China because they bought them from Innovent.

 

[HB_22]

As for weight loss, I don't know how you do math, but 24.2% weight loss in 48 weeks is slower than 15.4% in 24 weeks or 20.6% in 20 weeks.

There is your problem, you think this effect is proportional to the time being on the drug. Sadly it's not, most drugs will reach a point over time where we dont see any further effect if not going up in dose. With mazdutide we see that effect way sooner than with retatrutide. But I finally see how you came up with that nonsense. And yea I did invest in EL years ago but that has nothing to do with this debate.