Has anyone actually harmed their heart / kidneys from steroids in spite of having good BP and blood work?

[explodingHeart]

Title explains it all.

Just wondering if over a long period of time (10+ years) the effects of AAS directly on heart/kidney organs have caused users a lot of damage, independent of blood pressure, heart rate, blood work, etc.

 

[Intrepid]

Title explains it all.

Just wondering if over a long period of time (10+ years) the effects of AAS directly on heart/kidney organs have caused users a lot of damage, independent of blood pressure, heart rate, blood work, etc.

Definitely some ventricular heart remodeling from the GH. Studys show that even 4 weeks of superphysiological doses can cause changes.

Do I still use gh anyways? Yes

Supraphysiological Doses of GH Induce Rapid Changes in Cardiac Morphology and Function

Abstract. GH is an agent widely used in sport to improve physical performance and has been proposed as adjunctive therapy in several clinical conditions. H

academic.oup.com

"Low-dose GH did not significantly affect echocardiographic parameters. In contrast, high-dose GH increased left ventricular mass index by 12% (P < 0.05). The type of growth response was concentric, because left ventricular wall thickness but not diameter increased, leading to a 10% increase of relative wall thickness. These structural changes were associated with functional changes, including a significant increase in cardiac index and a decrease in peripheral vascular resistance; diastolic function was not altered. Fractional shortening and systemic blood pressure were unchanged in the two treatment groups.

In conclusion, administration of GH for 4 wk at doses that simulate GH abuse in sport caused a high cardiac output state associated with concentric left ventricular remodeling."

 

[FunkOdyssey]

Definitely some ventricular heart remodeling from the GH. Studys show that even 4 weeks of superphysiological doses can cause changes.

Do I still use gh anyways? Yes

Have you tried converting those doses to IU? I think 1 mg of HGH = 3 IU? So for a 200 lb man, the low dose was 8 IU and the high dose was 16 IU. Please correct me if my calculations are off, but if anything, this would suggest that a majority of GH users are not likely to develop LVH, at least not within the 4 week period studied.

 

[Intrepid]

Have you tried converting those doses to IU? I think 1 mg of HGH = 3 IU? So for a 200 lb man, the low dose was 8 IU and the high dose was 16 IU. Please correct me if my calculations are off, but if anything, this would suggest that a majority of GH users are not likely to develop LVH, at least not within the 4 week period studied.

I think this is a fair assessment

The changes at the more acceptable dosages might not take place over 4 weeks like in this study, but I do think prolonged use of 8iu+ will definitely lead to heart remodeling and increased thickness, just perhaps a bit slower

 

[PeterBond]

We see left ventricular hypertrophy quite regularly, also in the absence of hypertension. Kidneys we sometimes see decreased eGFR (based on cystatin c) and an increased albumin:creatinine ratio in urine. One of our patients, unfortunately, developed focal segmental glomerulosclerosis during a steroid cycle. He's been off for over a year now, and his eGFR is not showing any improvement (stuck around ~30), despite treatment.

 

[Liter O' Test]

Chase irons recently got a full torso MRI scan, his heart was within range, wasn't even enlarged to an athletes size despite using gear for more than a decade, including hgh for years, and most recently 18U of serostim for months and 3g of test.