MESO-Rx
Anabolic Steroids
I wonder if adding tirz to the stack might be a solution to counter the leptin resistance issues.
www.psychiatrist.com
Effect of Mirtazapine Treatment on Body Composition and Metabolism
Article Abstract Objective: Weight gain is a common side effect of psychotropic medications. Mirtazapine, a widely used antidepressant, induces adverse metabolic effects such as an increase in body weight. The aim of this study was to investigate the influence of mirtazapine treatment on body...
I got fat just reading the study results.
diabetesjournals.org
Get some rest man! Thanks for the link and thoughts. Very nice.Haha indeed.
Histamine plays an important part in heat production, energy balance/expenditure beyond leptin. So decreasing histamine signaling, as far as I know, decreases energy expenditure. But it's also important for leptin signaling pathway. And beyond that it also ties in many other processes revolving around energy balance/expenditure (brown adipose tissue, neuropeptides, etc.). I mean, blocking histamine as profoundly as mirtazapine does (it's the strongest antihistaminergic psychotropic drug to my knowledge) just wrecks pure havoc; from the immune system, energy expenditure to friking gut motility. It's why I said it's a dirty drug. I tried justifying it's use once to myself, so I did a little research, but this is as far as I went.
What's interesting though is that it kinda seems that people who have poor sleep (certainly something which is highly influenced through the histamine - orexin systems) seem to be more on the skinny side and have an easier time loosing weight and a harder time gaining weight. Might be a connection there involving, broadly speaking, histamine. And such people might not be at such a peril when using antihistaminergic drugs.
I'm to tired and today I've been on-line way beyond what's mentally healthy for me, so I can't further debate/research this (albeit interesting) topic now. But it certainly does disrupt leptin beyond increases in BMI and it certainly does predispose one to weight gain beyond pure increases in appetite (which is also down to mirt's 5HT2c antagonism btw, not just it's anti histamine action).
Central Infusion of Histamine Reduces Fat Accumulation and Upregulates UCP Family in Leptin-Resistant Obese Mice
Leptin resistance has recently been confirmed not only in animal obese models but in human obesity. Evidence is rapidly emerging that suggests that activat
Did you do 100 mcg before sleep? That would make a standard 2 mg vial last 20 days. Pretty cheap, assuming it's shelf life lasts that long? I'm intrigued
Haha indeed.
Histamine plays an important part in heat production, energy balance/expenditure beyond leptin. So decreasing histamine signaling, as far as I know, decreases energy expenditure. But it's also important for leptin signaling pathway. And beyond that it also ties in many other processes revolving around energy balance/expenditure (brown adipose tissue, neuropeptides, etc.). I mean, blocking histamine as profoundly as mirtazapine does (it's the strongest antihistaminergic psychotropic drug to my knowledge) just wrecks pure havoc; from the immune system, energy expenditure to friking gut motility. It's why I said it's a dirty drug. I tried justifying it's use once to myself, so I did a little research, but this is as far as I went.
What's interesting though is that it kinda seems that people who have poor sleep (certainly something which is highly influenced through the histamine - orexin systems) seem to be more on the skinny side and have an easier time loosing weight and a harder time gaining weight. Might be a connection there involving, broadly speaking, histamine. And such people might not be at such a peril when using antihistaminergic drugs.
I'm to tired and today I've been on-line way beyond what's mentally healthy for me, so I can't further debate/research this (albeit interesting) topic now. But it certainly does disrupt leptin beyond increases in BMI and it certainly does predispose one to weight gain beyond pure increases in appetite (which is also down to mirt's 5HT2c antagonism btw, not just it's anti histamine action).
Central Infusion of Histamine Reduces Fat Accumulation and Upregulates UCP Family in Leptin-Resistant Obese Mice
Leptin resistance has recently been confirmed not only in animal obese models but in human obesity. Evidence is rapidly emerging that suggests that activat
Effect of Mirtazapine Treatment on Body Composition and Metabolism
Article Abstract Objective: Weight gain is a common side effect of psychotropic medications. Mirtazapine, a widely used antidepressant, induces adverse metabolic effects such as an increase in body weight. The aim of this study was to investigate the influence of mirtazapine treatment on body...
I got fat just reading the study results.
Thanks for that. Very nice. I don't think I'll "treat" myself with the mirtazipine again. It makes me feel unclean.
it doesn’t seem to have that effect for everyone
Did you sort your AFIB in the end? Did AAS induce it?
Yeah it did sort out. Thanks for asking.
Thanks for the response. I'm glad you've got it under control. From what I hear, it's really uncomfortable. My Mum is currently on the waiting list for an ablation, so fingers crossed that will sort it for her as it's been years now, and so far, they have just been doing cardioversions, which usually fail within a couple of months.
