How long does it take for tolerance to HGH to disappear?

[smartgear]

I heard that the longer you take HGH, the more antibodies are built and less IGF-1 there will be.

But I didn't understand if this applies to systemic and local IGF-1 or only to systemic IGF-1.

If GH levels are 5.88 ng/mL, can this keep local IGF-1 high, even when tolerance is built to systemic IGF-1? Does the tolerance affect the 2 types of IGF-1 or only the first type?

How long does it take for tolerance to be built and how long should I be off HGH for the tolerance to disappear?

Isn't there a substance that clears the receptors and removes the tolerance without me having to cycle off and wait?

 

[topia]

This is interesting because in most HGH clinical trials they will have the children take regular, even daily doses for months and years. Medical professionals aren't a big fan of "cycling"

 

[smartgear]

This is interesting because in most HGH clinical trials they will have the children take regular, even daily doses for months and years. Medical professionals aren't a big fan of "cycling"

They are using therapeutic and replacement doses such as 1 or 2 IUs a day, these doses keep their GH levels within the reference range.

I'm using higher doses, such as 5 IUs a day, that make my GH level to be above the reference range.

It's understandable that tolerance doesn't built-up when GH level is within reference range. But what about when GH is above reference range for a very long time, and IGF-1 is also high although it's not above the reference range?

 

[topia]

They are using therapeutic and replacement doses such as 1 or 2 IUs a day, these doses keep their GH levels within the reference range.

I'm using higher doses, such as 5 IUs a day, that make my GH level to be above the reference range.

It's understandable that tolerance doesn't built-up when GH level is within reference range. But what about when GH is above reference range for a very long time, and IGF-1 is also high although it's not above the reference range?

My question is, why would a significant amount of antibodies be produced to "destroy" IGF-1 when your body produces this hormone by itself?

 

[hghlover]

Tons of people in here run HGH year round and have super high IGF 1 levels, by blood work. Not sure where this whole tolerance thing is coming from, as it's certainly not matched by real world blood work.

 

[smartgear]

Tons of people in here run HGH year round and have super high IGF 1 levels, by blood work. Not sure where this whole tolerance thing is coming from, as it's certainly not matched by real world blood work.

A supposedly experienced member on this forum told me about this tolerance a few days ago.

 

[TomGlass]

I heard that the longer you take HGH, the more antibodies are built and less IGF-1 there will be.

But I didn't understand if this applies to systemic and local IGF-1 or only to systemic IGF-1.

You only need to be concerned with "systemic" igf1 and developing antibodies is not a guarantee, it's rare. DMR....