how to make transdermal testosterone?

[GritzN'Gravy]

That much alcohol will be straight up shuttled to your bloodstream by that much DMSO.

If applying twice a day that's a risky business.

Not really, studies have proven as the alcohol evaporates, transdermal transmission increases.

Also dmso acts as a great solvent, so with the high concentration of the solution, the topical dosage volume is small.

Not much alcohol gets into your system.

 

[GritzN'Gravy]

DMSO is shredding my skin! lol
I might apply to areas that have rougher skin. Inside of elbows getting shredded xD
Anyone try anything out to aid in the drying/burning the DMSO causes?

Your concentration of dmso is too high.

If you change application site to somewhere with thicker skin, you defeat the whole purpose of using a transdermal.

Usually places with thinner skin, and more visible vascular network is used as an application site. Such as top of feet, inside of forearms, etc.

A lower concentration of dmso is actually better for absorbtion, within reason of course.

I've tried it at full concentration and my skin peeled when rubbed, and my fingers stayed wrinkled for days as the dmso drew excess water into my skin.

 

[Biggerp73]

The efficacy of dmso actually decreases after the concentration surpasses 75%.

What's your source for this information?

 

[GritzN'Gravy]

What's your source for this information?

I've used it in the laboratory, as well as in therapeutic interventions.

As such, it is important to remember what we are doing here is analogous to garage type, diy transdermal formulation.

In a clinical setting, when transdermals are used, most often the "drug" of choice is encapsulated in an amphiphilic micelle as part of a standardized transdermal delivery system.

When standardized dosages of medications are required most often iontophoresis with known pharmacodynamics is the transdermal system most often utilized.

if you would like citations/empirical data from peer reviewed sources, let me know.

 

[GritzN'Gravy]

I think if you wanted the Gritz n gravy, down and dirty, quickest, most efficient, most bioavavailable mode of action, you could easily make a solution of 75% dmso to 25% alcohol of choice.

Use a dropper bottle with your standardized concentration of solution and administer it sublingually/buccal route.

The absorbtion would be nearly immediate, no worries of cross contamination by touching others at the site of administration, no shaving, no manual rubbing for permeation, etc.

Probably would taste ass, but people do take dmso orally, so it would not hurt you.

 

[Biggerp73]

I think if you wanted the Gritz n gravy, down and dirty, quickest, most efficient, most bioavavailable mode of action, you could easily make a solution of 75% dmso to 25% alcohol of choice.

Use a dropper bottle with your standardized concentration of solution and administer it sublingually/buccal route.

The absorbtion would be nearly immediate, no worries of cross contamination by touching others at the site of administration, no shaving, no manual rubbing for permeation, etc.

Probably would taste ass, but people do take dmso orally, so it would not hurt you.

You the man, Gravy.

 

[Deleted member 59947]

Not really, studies have proven as the alcohol evaporates, transdermal transmission increases.

Also dmso acts as a great solvent, so with the high concentration of the solution, the topical dosage volume is small.

Not much alcohol gets into your system.

DMSO shuttles everything into the bloodstream including the layer of dirt on your skin you forgot to wash, but it magically leaves out the alcohol?

Please explain by what miracle.

DMSO is a great solvent for esterless hormones. Try dissolving a propionate into DMSO, impossible, you need alcohol added to it.

 

[Deleted member 59947]

I think if you wanted the Gritz n gravy, down and dirty, quickest, most efficient, most bioavavailable mode of action, you could easily make a solution of 75% dmso to 25% alcohol of choice.

Use a dropper bottle with your standardized concentration of solution and administer it sublingually/buccal route.

The absorbtion would be nearly immediate, no worries of cross contamination by touching others at the site of administration, no shaving, no manual rubbing for permeation, etc.

Probably would taste ass, but people do take dmso orally, so it would not hurt you.

Definitely burns your oesophagus at that concentration.
And I don't mean that as in "burning sensation".
It litterally eats through human tissues.

 

[Biggerp73]

I think if you wanted the Gritz n gravy, down and dirty, quickest, most efficient, most bioavavailable mode of action, you could easily make a solution of 75% dmso to 25% alcohol of choice.

Use a dropper bottle with your standardized concentration of solution and administer it sublingually/buccal route.

The absorbtion would be nearly immediate, no worries of cross contamination by touching others at the site of administration, no shaving, no manual rubbing for permeation, etc.

Probably would taste ass, but people do take dmso orally, so it would not hurt you.

Hey I just noticed you recommended oral administration. The transdermal I am making is site specific, so oral doesn't work. Would you still recommend 75% DMSO and 25% isopropyl alcohol?

 

[GritzN'Gravy]

Hey I just noticed you recommended oral administration. The transdermal I am making is site specific, so oral doesn't work. Would you still recommend 75% DMSO and 25% isopropyl alcohol?

That seems like a good concentration. You can add a surfactant also.

There seem to be several schools of thought.

Another being to place dmso on the skin, then applying your solution of choice on top.of that. This is intended to minimize the volume of dmso used, and the rationale being ot then "pulls" the secondary solution into the skin with it.

 

[may2021]

You just need to take a page from the Walenda Family book of spine elongation and gesticulate into licking your sack, bro. EASY does it.

 

[Deleted member 59947]

That seems like a good concentration. You can add a surfactant also.

There seem to be several schools of thought.

Another being to place dmso on the skin, then applying your solution of choice on top.of that. This is intended to minimize the volume of dmso used, and the rationale being ot then "pulls" the secondary solution into the skin with it.

Along with all the additives your secondary solution contains.

 

[Deleted member 59947]

Anyone else has recently been playing with transdermal solutions and having good results?

 

[Tmisatix]

Anyone else has recently been playing with transdermal solutions and having good results?

May be trying transdermal dhb soon

I’d make all injectable compounds td if I was willing to go the raws route. Hesitant to , though. It’s so easy , just mix dmso or phlojel with compound. No ester Base drugs probably work the best

 

[Megadick3000]

Anyone else has recently been playing with transdermal solutions and having good results?

Few years back i did alot of fucking around with no ester testosterone freebase. Heres the experiments i did that i ended up using, my memory may be a bit foggy on the specifics:

1) TNE in 100% DMSO base - this was the best for transdermal

2) TNE in Phlojel - this did not feel nearly as effective, was also a bitch to get it to uniformly dissolve in the phlojel

3) TNE in PEG400 + DMSO - I forget the ratios but when adding the peg400 and dmso together it immediately formed this waxy cream. Application wise this was nice as unlike the pure DMSO which flowed like water this was more like a professional product it stayed where i applied it, not sure if this was as effectively absorbed as the pure DMSO version though

4) TNE encapsulated in hydroxy-propyl-betacyclodextrin (HPBCD) dissolved into water - HPBCD allows TNE to dissolve in water, opening up various other methods of administration. Using this cyclodextrin encapsulated TNE i made the following experiments:

A. Intranasal spray - great for pre workout, annoying to maintain blood level all day long needing numerous administrations daily, made throat dry and scratchy, got me high everytime, the kind of high where you dont realize how high you are until it wears off. Read a study showing intranasal administration of testosterone achieves dramatically higher brain concentrations of Testosterone verse any other route of administration

B. Gummy bears - made the TNE/HPBCD complex into gummy bear candies, would chew them for a few seconds then they stick to my gums where id leave them to dissolve for sublingual/buccal/gingival route of administration. Worked but seems this route of administration is very limited in how much you can absorb in a given time frame. Despite increasing dosages i could not notice increased effects. Read a study that confirmed transmucosal oral route seems to have an absorption limit between 20-40mg in a dosing period.

C. Water drops - just TNE/HPBCD in water dropped under the tongue. Same issue as the gummy bears increasing dosage size did not seem to increase effect.

D. SubQ injectable - made this as TNE/HPBCD in bac water injectable for subq administration. Unfortunately it seemed to partially crash when left overnight revealing some small particles the next day, decided not to inject.


Of all these the two most relevant were the cyclotestosterone nasal spray and the pure DMSO transdermal. The big issue with the pure DMSO transdermal was the consistency of water making applying it messy and annoying as it would drip down my body. Using PEG400 with the DMSO to form a waxy feeling cream gave a real nice application and is worth exploring further.

 

[powerandmuscle]

Few years back i did alot of fucking around with no ester testosterone freebase. Heres the experiments i did that i ended up using, my memory may be a bit foggy on the specifics:

1) TNE in 100% DMSO base - this was the best for transdermal

2) TNE in Phlojel - this did not feel nearly as effective, was also a bitch to get it to uniformly dissolve in the phlojel

3) TNE in PEG400 + DMSO - I forget the ratios but when adding the peg400 and dmso together it immediately formed this waxy cream. Application wise this was nice as unlike the pure DMSO which flowed like water this was more like a professional product it stayed where i applied it, not sure if this was as effectively absorbed as the pure DMSO version though

4) TNE encapsulated in hydroxy-propyl-betacyclodextrin (HPBCD) dissolved into water - HPBCD allows TNE to dissolve in water, opening up various other methods of administration. Using this cyclodextrin encapsulated TNE i made the following experiments:

A. Intranasal spray - great for pre workout, annoying to maintain blood level all day long needing numerous administrations daily, made throat dry and scratchy, got me high everytime, the kind of high where you dont realize how high you are until it wears off. Read a study showing intranasal administration of testosterone achieves dramatically higher brain concentrations of Testosterone verse any other route of administration

B. Gummy bears - made the TNE/HPBCD complex into gummy bear candies, would chew them for a few seconds then they stick to my gums where id leave them to dissolve for sublingual/buccal/gingival route of administration. Worked but seems this route of administration is very limited in how much you can absorb in a given time frame. Despite increasing dosages i could not notice increased effects. Read a study that confirmed transmucosal oral route seems to have an absorption limit between 20-40mg in a dosing period.

C. Water drops - just TNE/HPBCD in water dropped under the tongue. Same issue as the gummy bears increasing dosage size did not seem to increase effect.

D. SubQ injectable - made this as TNE/HPBCD in bac water injectable for subq administration. Unfortunately it seemed to partially crash when left overnight revealing some small particles the next day, decided not to inject.


Of all these the two most relevant were the cyclotestosterone nasal spray and the pure DMSO transdermal. The big issue with the pure DMSO transdermal was the consistency of water making applying it messy and annoying as it would drip down my body. Using PEG400 with the DMSO to form a waxy feeling cream gave a real nice application and is worth exploring further.

Don`t forget the awesome iron-legion Salvo advanced transdermal carrier . IT works well but it is wery hard to find inside eu. At least i have not find it anymore ! If some one know a source inside eu please put pm. TNE/HPBCD in water dropped under the tongue, allso works wery well, with that a few world champs medals have been taken in different sports

 

[Deleted member 59947]

Few years back i did alot of fucking around with no ester testosterone freebase. Heres the experiments i did that i ended up using, my memory may be a bit foggy on the specifics:

1) TNE in 100% DMSO base - this was the best for transdermal

2) TNE in Phlojel - this did not feel nearly as effective, was also a bitch to get it to uniformly dissolve in the phlojel

3) TNE in PEG400 + DMSO - I forget the ratios but when adding the peg400 and dmso together it immediately formed this waxy cream. Application wise this was nice as unlike the pure DMSO which flowed like water this was more like a professional product it stayed where i applied it, not sure if this was as effectively absorbed as the pure DMSO version though

4) TNE encapsulated in hydroxy-propyl-betacyclodextrin (HPBCD) dissolved into water - HPBCD allows TNE to dissolve in water, opening up various other methods of administration. Using this cyclodextrin encapsulated TNE i made the following experiments:

A. Intranasal spray - great for pre workout, annoying to maintain blood level all day long needing numerous administrations daily, made throat dry and scratchy, got me high everytime, the kind of high where you dont realize how high you are until it wears off. Read a study showing intranasal administration of testosterone achieves dramatically higher brain concentrations of Testosterone verse any other route of administration

B. Gummy bears - made the TNE/HPBCD complex into gummy bear candies, would chew them for a few seconds then they stick to my gums where id leave them to dissolve for sublingual/buccal/gingival route of administration. Worked but seems this route of administration is very limited in how much you can absorb in a given time frame. Despite increasing dosages i could not notice increased effects. Read a study that confirmed transmucosal oral route seems to have an absorption limit between 20-40mg in a dosing period.

C. Water drops - just TNE/HPBCD in water dropped under the tongue. Same issue as the gummy bears increasing dosage size did not seem to increase effect.

D. SubQ injectable - made this as TNE/HPBCD in bac water injectable for subq administration. Unfortunately it seemed to partially crash when left overnight revealing some small particles the next day, decided not to inject.


Of all these the two most relevant were the cyclotestosterone nasal spray and the pure DMSO transdermal. The big issue with the pure DMSO transdermal was the consistency of water making applying it messy and annoying as it would drip down my body. Using PEG400 with the DMSO to form a waxy feeling cream gave a real nice application and is worth exploring further.

Very valuable info on the PEG 400 ! Thank you.
I'm having the best success with TNE in pure DMSO as well, but just like you, I would like to find a way to not have it drip.
Only issue is DMSO shuttles everything to the blood with extreme efficacy, so that addition would have to be absolutely non-toxic.

 

[Deleted member 59947]

My neighbor just did a dht Creme with dht powder, dmso and peg400 as moisturizer (aloe Vera wasn’t available).
i can give update in some weeks. It’s only 10% but he will use it 2-3 times a day

Any update on this?
Do you know how he incorporated the liquid dmso in a gel like substance? How do you make this homogenous?

 

[z666z]

Isn't transdermal only shuttling 40% of your raws.

If you buy a kilo of Test Base that means only 400 grams is absorbed, that seems like a huge waste of raws.

 

[hightest]

Isn't transdermal only shuttling 40% of your raws.

If you buy a kilo of Test Base that means only 400 grams is absorbed, that seems like a huge waste of raws.

No absorption with DMSO should be higher. Also, Test base is cheap as shit so even if you don't fully absorb, it still remains very affordable