how to make transdermal testosterone?

[john_snow]

Apply it liberally from the bottle straight, not with a dropper. Like 4ml at a time.

4ml per day you say? or 4ml per application?

Assuming it’s 4ml per day of a 160mg/ml solution, I’d be using 640mg of T per day to reach approximately the same levels as 75mg per day would bring if I used DMSO instead. Is that correct?

Does the dropper bring any issues?

 

[FuckinNoob]

So I made a 50mg/ml solution using test base and 100% DMSO. Applied 1ml and the shit stings pretty good, nothing terrible but a constant mild burn feeling. Also looks like a rash might be forming.

This comment is within about 10 mins of application. Probably should’ve started with .5ml. Will update later

 

[john_snow]

Just made a bottle with:

4,5g micronized T powder from PPL
25ml 96% ethanol
3ml isopropyl myristate

Applied 2ml to scrotum an hour ago. Not feeling a damn thing :/

The solution dried in seconds, almost instantly, and I can feel the skin ended up dry with powder coating it

First time experimenting with T ever. Bloodwork from a few months ago said 792ng/dl

Probably doing something wrong? I'd like to try DMSO but it's difficult to source good quality in argentina

 

[shine]

So I made a 50mg/ml solution using test base and 100% DMSO. Applied 1ml and the shit stings pretty good, nothing terrible but a constant mild burn feeling. Also looks like a rash might be forming.

This comment is within about 10 mins of application. Probably should’ve started with .5ml. Will update later

You can add urea to the solution, it will sting less.

 

[FuckinNoob]

Redness/irritation from the dmso went away after about 2 hours. Not sure how much absorbed, I’ll have to take bloods after a few weeks to check efficacy.

I applied to the clavicles/upper chest, since I’m a bit weary about the high conversion to DHT via transscrotal application (as recommended by goingstronger). Trying to preserve my hairline.

I’m essentially trying to accomplish a mild beginner’s T cycle with this method so if anyone’s interested I can update with before/after photos/metrics here

 

[Bullet_Proof]

Just made a bottle with:

4,5g micronized T powder from PPL
25ml 96% ethanol
3ml isopropyl myristate

Applied 2ml to scrotum an hour ago. Not feeling a damn thing :/

The solution dried in seconds, almost instantly, and I can feel the skin ended up dry with powder coating it

First time experimenting with T ever. Bloodwork from a few months ago said 792ng/dl

Probably doing something wrong? I'd like to try DMSO but it's difficult to source good quality in argentina

I'm thinking that your concentration was too high? 4500mg divided by approximately 30ml is 150mg/ml. I'm assuming this was test base, right? I'm no expert on this and am curious what other people have to say.

 

[Deleted member 59947]

I'm thinking that your concentration was too high? 4500mg divided by approximately 30ml is 150mg/ml. I'm assuming this was test base, right? I'm no expert on this and am curious what other people have to say.

Max concentration of test base in pure ethanol is 160mg/ml :

https://purehost.bath.ac.uk/ws/portalfiles/portal/187942283/Dermatopharmacokinetics_as_a_tool_to_characterise_the_performance_of_testosterone_transdermal_formulations

 

[Deleted member 59947]

4ml per day you say? or 4ml per application?

Assuming it’s 4ml per day of a 160mg/ml solution, I’d be using 640mg of T per day to reach approximately the same levels as 75mg per day would bring if I used DMSO instead. Is that correct?

Does the dropper bring any issues?

I picked a random number in the hope you would understand the exact dosage doesn't matter, just apply a lot until you feel something.

3 options :

1) you didn't let it mix long enough for the T to completely dissolve

2) your T is bunk

3) you are expecting too much from testosterone

 

[wiitto]

100% DMSO works.
You can just for example get 30 ml brown glas dropper bottles.
Put the DHT in it, add the DMSO, wait a bit for it to dissolve. No heat, no shaking required.
If I remember correctly you can dissolve approx. 50mg/ml. So around 1.5 g in a 30 ml bottle.

Would this recipe work with anadrol?
Inj anadrol is my fav sterons but i cant source it so must improvise with transdermal one.

Any tips for making transdermal anadrol?
Thanks in advance

 

[Chris6]

Just made a bottle with:

4,5g micronized T powder from PPL
25ml 96% ethanol
3ml isopropyl myristate

Applied 2ml to scrotum an hour ago. Not feeling a damn thing :/

The solution dried in seconds, almost instantly, and I can feel the skin ended up dry with powder coating it

First time experimenting with T ever. Bloodwork from a few months ago said 792ng/dl

Probably doing something wrong? I'd like to try DMSO but it's difficult to source good quality in argentina

that formula didnt work me, too high in ethanol content. do 50/50. So half ethanol half other carrier (i.e. IPM or even MCT oil) and it doesn't dry out like that. Too much ethanol concentration and it dries too fast and doesn't absorb

 

[FuckinNoob]

If I apply the DMSO/TNE to my clavicle/upper chest it burns like shit and leaves a temporary rash. If I apply it to the top of my feet/wrists it basically feels like nothing, and leaves no mark. Any idea why that is?

I would think the absorption would be better on top of my feet/wrists since it’s really thin skin.

 

[tesarpaul]

that formula didnt work me, too high in ethanol content. do 50/50. So half ethanol half other carrier (i.e. IPM or even MCT oil) and it doesn't dry out like that. Too much ethanol concentration and it dries too fast and doesn't absorb

Did you try that formula? Does it dissolve completely without any issues?

 

[Chris6]

Did you try that formula? Does it dissolve completely without any issues?

doesn't work form me, dries too fast and white powder just coat my shoulders. 50/50 works fine though as it doesn't dry immediately and can absorb. no issue with dissolving DHEA in that formula

 

[Deleted member 59947]

doesn't work form me, dries too fast and white powder just coat my shoulders. 50/50 works fine though as it doesn't dry immediately and can absorb. no issue with dissolving DHEA in that formula

If you want something that doesn't dry so fast :

20g test base or DHEA
50ml benzyl alcohol
50ml isopropyl myristate

That makes a 20% solution with a lot more absorption potential than with ethanol and no white residue as benzyl alcohol is such a strong solvent.

Apply 1ml to 3ml at a time.

Crazy strong, but I can't vouch for the long term side effects of that much benzyl alcohol in your bloodstream.

 

[callisto]

If you want something that doesn't dry so fast :

20g test base or DHEA
50ml benzyl alcohol
50ml isopropyl myristate

That makes a 20% solution with a lot more absorption potential than with ethanol and no white residue as benzyl alcohol is such a strong solvent.

Apply 1ml to 3ml at a time.

Crazy strong, but I can't vouch for the long term side effects of that much benzyl alcohol in your bloodstream.

what would be the best topical solution for maximal absorbtion and minimal skin irritation?
also whats the optimal concentration of dht for injectable and topical?

 

[Deleted member 59947]

what would be the best topical solution for maximal absorbtion and minimal skin irritation?
also whats the optimal concentration of dht for injectable and topical?

Anytime you increase skin penetration you de facto increase irritation.

ethanol
benzyl alcohol
DMSO

in increasing order of penetration and irritation

 

[pstnf1]

Anytime you increase skin penetration you de facto increase irritation.

ethanol
benzyl alcohol
DMSO

in increasing order of penetration and irritation

Goingstronger, may I ask what ratio of ethanol/IPM you would recommend to avoid john_snow's problem?

 

[john_snow]

Been applying the transdermal T for 10 days now.

I don't feel a change in mood or energy.

Strength I don't know because I haven't been lifting this week.

What I can surely note is that I'm getting lots of water retention, particularly on my face.

I used to have the cheeks saggy and full of water when I lifted and stressed my body everyday. That went away when I started taking some Pregnenolone and DHEA (Pansterone), vitamin K2 (kuinone) and thyroid (tyromix) and reduced the training stress (all this before T).

My face was tight and lean until now that I started applying the T solution. And that's mostly the only change that I can attribute to it, maybe a bit more energy but not significant enough to attribute.

I have the theory that I used to get this face from cortisol, and now I'm getting it from aldosterone because of the T

 

[tesarpaul]

Been applying the transdermal T for 10 days now.

I don't feel a change in mood or energy.

Strength I don't know because I haven't been lifting this week.

What I can surely note is that I'm getting lots of water retention, particularly on my face.

I used to have the cheeks saggy and full of water when I lifted and stressed my body everyday. That went away when I started taking some Pregnenolone and DHEA (Pansterone), vitamin K2 (kuinone) and thyroid (tyromix) and reduced the training stress (all this before T).

My face was tight and lean until now that I started applying the T solution. And that's mostly the only change that I can attribute to it, maybe a bit more energy but not significant enough to attribute.

I have the theory that I used to get this face from cortisol, and now I'm getting it from aldosterone because of the T

My mistake from the beggining was having too much expectations from the test base. Because I saw all the gains that people got from TRT and the conclusion is that you are not able to get the same results with transdermals steroids.

But my energy levels are much higher, libido is great and my hair dont fall. Plus you know what exactly you are applying and you have to worry about the PUFA and other shit you get with injections.

 

[Deleted member 59947]

Goingstronger, may I ask what ratio of ethanol/IPM you would recommend to avoid john_snow's problem?

No tweaking of the ratio is going to prevent white residue from staying.

If you want a fully dissolved solution with no residue on the skin, use :

- 20g test base powder
- 50ml benzyl alcohol
- 50ml IPM

For a 100ml solution

This solution feels MUCH stronger than with the ethanol, the testosterone mental effects such as confidence and energy throughout the day are very pronounced.