IGF Results on 4 IUs HGH

[PigsOnTheWing]

Hello all,

I've been running HGH for the past several years from the same supplier. My IGF baseline was 106 ng/mL back in 2016 when I was natural. Since starting GH, my IGF levels have always come back in the high 200's. My most recent test back in July of this year came back at 299 ng/mL running 4 iu's a day. Last year, my levels were at 278 ng/mL running 3 iu's a day.

Last week, I had my levels checked again and they came back low at 142 ng/mL, meaning my latest supply of GH is bunk. However, I usually get my labs done at LabCorp. This latest test was done with Quest for the first time, and the results had a note I have never seen before. Anyone have any idea what it means?

"Based on the mass-spectrometric data, a rare heterozygous IGF-1 variant was detected in this specimen. The level of this variant was not included in the reported IGF-1 result above, which explains a potentially lower than expected value. The level of the variant is expected to be the same as the value reported for the Wild Type IGF-1 protein. The clinical significance of this IGF-1 variant remains unknown. Additional DNA sequencing is recommended to confirm the presence of the variant."

If I go off GH, I notice my sleep goes back to shit after a week, the way it was before I started taking GH (i.e. significantly less deep and restful sleep, waking frequently throughout the night etc.), but I've still been sleeping really well lately which makes me think my latest batch of GH may not be bunk and these Quest results are off for the reasons stated above? I'm going to get a follow-up IGF test with LabCorp next week to see whether the results are similar, but want to hear your guys' thoughts.

Thanks

 

[Tim22]

Tough one .. It's so hard to tell anymore. Also so hit or miss with all this UGL HGH.If you call anyone out .They te you you must not be a good converter for igf and their hgh is good. Other call you put of you have feels side effects. Other give good reviews cause they get freebies Monstro on here will tell u a bottle of shit is good if he gets it free to try out. He was all over Qtropin till they cut him off. It's all bullshit

 

[PigsOnTheWing]

I asked my brother who's a doctor to interpret the results in case anyone's interested. I'm still going to get my IGF levels tested along with a serum GH test at LabCorp in a week or two but this is what my bro had to say:

"You body has two copies of a gene to produce a protein. One of your IGF genes is this "variant" and the other is the normal version. This variant may or may not be dysfunctional, I cant say based on these results . . .

One amino acid change in the middle of a protein sequence can either result in the rest of that protein from not being produced (ie, a smaller, non functional protein), can not result in any significant change or problem, or still produces the whole protein, but is less functional

Based on the Quest analysis using "mass spectroscopy" they actually measured the size/weight of your circulating IGF-1, whereas Labcorp uses another type of assay that just binds to a specific, commong part of the IGF protein, without identifying the full protein

Your total IGF levels likely haven't changed - just multiply your current number by 2, at that is likely what you Labcorp level is

The "variant" is your own intrinsic production of IGF stimulated by the endogenous GH - your GH is probably the same"

 

[Megadick3000]

I asked my brother who's a doctor to interpret the results in case anyone's interested. I'm still going to get my IGF levels tested along with a serum GH test at LabCorp in a week or two but this is what my bro had to say:

"You body has two copies of a gene to produce a protein. One of your IGF genes is this "variant" and the other is the normal version. This variant may or may not be dysfunctional, I cant say based on these results . . .

One amino acid change in the middle of a protein sequence can either result in the rest of that protein from not being produced (ie, a smaller, non functional protein), can not result in any significant change or problem, or still produces the whole protein, but is less functional

Based on the Quest analysis using "mass spectroscopy" they actually measured the size/weight of your circulating IGF-1, whereas Labcorp uses another type of assay that just binds to a specific, commong part of the IGF protein, without identifying the full protein

Your total IGF levels likely haven't changed - just multiply your current number by 2, at that is likely what you Labcorp level is

The "variant" is your own intrinsic production of IGF stimulated by the endogenous GH - your GH is probably the same"

So basically your some mutant with Alien IGF-1 variant genes???

Honestly this is the first ive ever heard of something like this so i cant contribute anything other than nonsense.

 

[bluzzer]

This is interesting. Maybe you body gets worser over time to convert the exogenous GH..

Have you ever played with long acting insulin like Lantus? It should bind hard to the igf1 receptor and give it a bunk upwards

 

[PigsOnTheWing]

So basically your some mutant with Alien IGF-1 variant genes???

Honestly this is the first ive ever heard of something like this so i cant contribute anything other than nonsense.

That is what appears to be the case if my brother is right. Won't know for sure until I get the labs redone at LabCorp next week.

 

[PigsOnTheWing]

This is interesting. Maybe you body gets worser over time to convert the exogenous GH..

Have you ever played with long acting insulin like Lantus? It should bind hard to the igf1 receptor and give it a bunk upwards

I wouldn't be surprised. If my brother is right and I multiply the Quest value by two, that's basically the same IGF level at 4 IU as it was last year at 3 IU. Seems like my body's getting worse at converting or I've reached the point of diminishing returns. Or the the quality of my GH has gotten worse.

Never tried Slin and probably won't ever. I'm not too concerned with my IGF levels as long as they're below acromegaly territory. I just like to use IGF to gauge whether my GH is real and working. I don't take GH for bodybuilding purposes other than helping me stay leaner.

 

[Deleted member 123722]

@GoodLyfe has good GH. I got 371 at 5ius ed... I only took 2.5ius right before the blood test that morning. (not sure if that matters).

 

[bluzzer]

I wouldn't be surprised. If my brother is right and I multiply the Quest value by two, that's basically the same IGF level at 4 IU as it was last year at 3 IU. Seems like my body's getting worse at converting or I've reached the point of diminishing returns. Or the the quality of my GH has gotten worse.

Never tried Slin and probably won't ever. I'm not too concerned with my IGF levels as long as they're below acromegaly territory. I just like to use IGF to gauge whether my GH is real and working. I don't take GH for bodybuilding purposes other than helping me stay leaner.

What range is below acromegaly territory?

 

[PigsOnTheWing]

@GoodLyfe has good GH. I got 371 at 5ius ed... I only took 2.5ius right before the blood test that morning. (not sure if that matters).

Thanks for the suggestion. I've been reading a lot of good reviews for GoodLyfe lately. May need to make the switch.

 

[PigsOnTheWing]

What range is below acromegaly territory?

Haha good point. I guess anything over 400 would have me concerned, so I've got some room to move up still. High 200's/low 300's is what I'm shooting for though.

 

[Isrrike]

Maybe this is a stupid question but if you haven’t been diagnosed with cancer is it safe to say you’re. All clear to run or should people get a marker test before running gh if they have family history

 

[PigsOnTheWing]

Not sure what marker tests you could get. There is a theoretical increased risk of cancer with HGH use, but a direct casual link between HGH/elevated IGF levels and cancer has never been proven as far as I know. It's all based on correlation, but I could be wrong. Here are a couple of studies showing no evidence that HGH causes cancer, although one of these studies mentions that "GH/IGF-1 provides an anti-apoptotic environment that may favour survival of genetically damaged cells."

Does growth hormone cause cancer? - PubMed

The ability of GH, via its mediator peptide IGF-1, to influence regulation of cellular growth has been the focus of much interest in recent years. In this review, we will explore the association between GH and cancer. Available experimental data support the suggestion that GH/IGF-1 status may...

pubmed.ncbi.nlm.nih.gov

Growth Hormone’s Links to Cancer

Abstract. Several components of the GH axis are involved in tumor progression, and GH-induced intracellular signaling has been strongly associated with bre

academic.oup.com

In my opinion, when used responsibly, HGH is one of the safest and most side-effect free drugs you could use, and this is coming from someone who has lost a couple close relatives to cancer. I believe that the increased health benefits from HGH, such as significantly improved sleep quality, are enough to outweigh any potential risks such as cancer or diabetes. I also think a lot of the cancer fears stem from that dumb shit NFL player who blamed his cancer on steroids and HGH in the 80s.

 

[PigsOnTheWing]

Lab results are back from LabCorp. IGF levels are at 383, so looks like my HGH is still legit and the Quest results were inaccurate.

I went with Quest because they were cheaper, but looks like they are cheaper for a reason. Ironically, I ended up spending more money because I had to have the test performed twice. Opening that LabCorp PDF earlier this morning felt like I was a high school student looking at my SAT scores for the first time.

 

[Deadp007]

Thank you for keeping up with this thread...I was reading it thinking "f*@k, this is old and he's going to ghost, I should stop reading".
So glad I didn't.
I'm wanting to get a base & know where I'll get tested.
Mad props to PotW!!!