Interesting study on Anadrol - would appreciate Dr Scally's comments

[cvictorg]

http://retroconference.org/2004/cd/PDFs/725.pdf

Study Design: Double-blind, randomized, placebo-controlled trial of 89 HIV-positive women and men with wasting assigned to the anabolic steroid oxymetholone (50 mg BID or TID) or placebo for 16 weeks followed by open-label treatment.

Overall, 35% of patients in the TID, 27% of patients in the BID oxymetholone group and no patients the placebo group had a greater than 5 times baseline increase for ALT during the double-blind phase of the study.Conclusions: Oxymetholone can be considered an effective anabolic steroid in eugonadal male and female patients with AIDS-associated wasting. The BID (100 mg/day) regimen appeared to be equally effective to the TID (150 mg/day) regimen in terms of weight gain, LBM and BCM and was associated with less, but still significant liver toxicity.

Could you clarify what TID and BID mean in terms of frequency of dosage as well as your thoughts on the study. Also - this study was for a duration of 16 weeks - what would you say to someone taking a dose like this or less for 6 weeks?

 

[cvictorg]

http://retroconference.org/2004/cd/PDFs/725.pdf

Study Design: Double-blind, randomized, placebo-controlled trial of 89 HIV-positive women and men with wasting assigned to the anabolic steroid oxymetholone (50 mg BID or TID) or placebo for 16 weeks followed by open-label treatment.

Overall, 35% of patients in the TID, 27% of patients in the BID oxymetholone group and no patients the placebo group had a greater than 5 times baseline increase for ALT during the double-blind phase of the study.Conclusions: Oxymetholone can be considered an effective anabolic steroid in eugonadal male and female patients with AIDS-associated wasting. The BID (100 mg/day) regimen appeared to be equally effective to the TID (150 mg/day) regimen in terms of weight gain, LBM and BCM and was associated with less, but still significant liver toxicity.

Could you clarify what TID and BID mean in terms of frequency of dosage as well as your thoughts on the study. Also - this study was for a duration of 16 weeks - what would you say to someone taking a dose like this or less for 6 weeks?

Got the answer to one question - BID - twice/day - TID - Three times/day

 

[Michael Scally MD]

The full article is attached. Oxymetholone is hard on the liver. Winstrol is even harder and more toxic to the liver, particularly if oral. There are so many areas to comment on Oxymetholone, it is better to ask a specific question. The article might give more insight into effects at 6 weeks.

 

[cvictorg]

The full article is attached. Oxymetholone is hard on the liver. Winstrol is even harder and more toxic to the liver, particularly if oral. There are so many areas to comment on Oxymetholone, it is better to ask a specific question. The article might give more insight into effects at 6 weeks.

The article says that all liver-related grade 4 side effects were
reversible upon cessation of the study drug - so - would taking 50mgs of this per day for 6 weeks cause irreversible problems? The study says no - what do you say

Adverse Events
Adverse events are shown in Table 3. The most
important adverse event was liver-associated toxicity
occurring in 12 (43%) patients in the tid group,
7 (25%) patients in the bid oxymetholone group,
and 2 (8%) individuals in the placebo group, respectively.
When the percentage of patients with
grade 3/4 liver toxicity (AST, ALT, or ?GT > 5 times
of baseline) was analyzed, the dose dependence
became clearly evident (Figure 4). As soon as 4
weeks after beginning treatment, 23% of patients
receiving 50 mg tid experienced grade 3/4 increases
in liver function tests as compared with 8%
of patients receiving 50 mg bid and 0% of placebo
patients, respectively. At week 16, 28% of patients
receiving 50 mg tid and 25% of individuals on 50
mg bid had at least one grade 3/4 liver toxicity as
compared with 5% in the placebo group, respec-
tively. One patient in the oxymetholone bid group
developed jaundice probably due to canaliculous
cholestasis and hepatomegaly.
The single most frequent laboratory abnormality
was an elevation of AST observed in 16 (26%) individuals
undergoing oxymetholone therapy. Total
bilirubin did not significantly change in any study
group. All liver-related grade 4 side effects were
reversible upon cessation of the study drug

 

[Michael Scally MD]

I agree. But, the patients are monitored, have no pre-existing LFT problems or otherwise, and most of all are not chronic AAS users. This is a big difference!!! This has no translation to the nonprescription (illicit) AAS user.