Marijuana [Cannabis]

Discussion in 'General Discussion' started by biggerandbetter, May 8, 2011.

  1. movingiron88

    movingiron88 Member

    Yes click the link. You need to properly decarb the weed. Yours might work but there are more efficient ways to extract more thc.
     
    hurricane likes this.
  2. GymRaccoon

    GymRaccoon Member

    I can understand he could get more out of the flower he is using, but not why he has so much inconsistency between pieces in the same batch of brownies...unless I read something wrong.
     
    hurricane likes this.
  3. hurricane

    hurricane Member

    Don't understand the inconsistencies myself.
     
  4. Michael Scally MD

    Michael Scally MD Doctor of Medicine

     
    hurricane and Seven like this.
  5. Michael Scally MD

    Michael Scally MD Doctor of Medicine

    [OA] The Relationship between Marijuana Use Prior to Sex and Sexual Function in Women

    Introduction - Scientific research on the effects of marijuana on sexual functioning in women, including libido, arousal, orgasm, and satisfaction, is limited.

    Aim - To evaluate women’s perceptions of the effect of marijuana use before sexual activity.

    Methods - A cross-sectional design, from March 2016–February 2017, within a single, academic, obstetrics and gynecology practice, was performed. Patients were given a questionnaire at their visit and asked to complete it anonymously and place it in a locked box after their visit.

    Main Outcome Measures - The primary outcome was satisfaction in the sexual domains of drive, orgasm, lubrication, dyspareunia, and overall sexual experience. The secondary outcome was the effect of the frequency of marijuana use on satisfaction.

    Results - Of the 373 participants, 34.0% (n = 127) reported having used marijuana before sexual activity. Most women reported increases in sex drive, improvement in orgasm, decrease in pain, but no change in lubrication.

    After adjusting for race, women who reported marijuana use before sexual activity had 2.13 higher odds of reporting satisfactory orgasms (adjusted odds ratio = 2.13; 95% CI = 1.05, 4.35) than women who reported no marijuana use.

    After adjusting for race and age, women with frequent marijuana use, regardless of use before sex or not, had 2.10 times higher odds of reporting satisfactory orgasms than those with infrequent marijuana use (adjusted odds ratio = 2.10; 95% CI = 1.01–4.44).

    Conclusion - Marijuana appears to improve satisfaction with orgasm. A better understanding of the role of the endocannabinoid system in women is important, because there is a paucity of literature, and it could help lead to development of treatments for female sexual dysfunction.

    Lynn BK, López JD, Miller C, et al. The Relationship between Marijuana Use Prior to Sex and Sexual Function in Women. Sex Med 2019;7:192–197. https://www.smoa.jsexmed.org/article/S2050-1161(19)30009-1/fulltext
     
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  6. Michael Scally MD

    Michael Scally MD Doctor of Medicine

    [OA] Effects of Cannabinoids on Female Sexual Function

    Introduction - With the legalization of both medical and recreational marijuana in some countries and a few US states, its use has become more widely prevalent. Both exogenous cannabinoids such as tetrahydrocannabinol (THC) and endogenous cannabinoids (endocannabinoids) have been shown to affect female gonadotropin pathways and female sexuality. Yet, our understanding of the mechanisms and effects on female sexual function is limited.

    Aim - To review the literature regarding the effects of both endogenous and exogenous cannabinoids on female sexual function in both animals and humans.

    Methods - We performed a PubMed search for English-language articles in peer-reviewed journals between 1970 and 2019. We used the following search terms: “cannabinoids,” “endocannabinoids,” “marijuana,” “cannabis,” and “female sexual function” or “sexual function.” The main outcomes of the papers were reviewed.

    Main Outcome Measure - The main outcome measure was sexual function in females.

    Results - A total of 12 human studies and 8 animal studies that evaluated the relationship between cannabinoids and female sexual function were included. Study types in animals were blinded, prospective, placebo-controlled trials. Human studies were based primarily on questionnaire data. The data indicate dose-dependent effects on female sexual desire and receptivity, such that low doses generally facilitate or have no effect but high doses inhibit.

    Conclusions - More research is needed to develop a better understanding of the effects of cannabinoids on female sexual function. There does appear to be an effect on both animals and humans, but whether the effect is positive or negative along dose and species lines requires more study. With the legalization of marijuana occurring in more countries and more US states, there needs to be more well-controlled studies evaluating the effects.

    Lynn B, Gee A, Zhang L, et al. Effects of Cannabinoids on Female Sexual Function. J Sex Med 2019. Effects of Cannabinoids on Female Sexual Function - ScienceDirect
     
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  7. Michael Scally MD

    Michael Scally MD Doctor of Medicine

    [OA] Stoned Sex: The Influence of Social Norms and Expectancies on Sex While Experiencing the Effects of Cannabis

    Though it is currently still classified as an illicit substance at the federal level, cannabis, or marijuana, is being decriminalized and legalized in an increasing number of states and territories in the United States. At the same time, there is evidence to suggest that use is increasing and attitudes towards use are becoming more permissive.

    While rates of cannabis use increase as individuals become more positive in their attitudes towards use, relatively little research has been devoted to the sexual effects of acute cannabis intoxication, including what sexual behavior people engage in while experiencing the effects and what their subjective sexual experience is like, nor what factors might be influencing these outcomes.

    Two such factors, perceived social norms and sex-related expectancies, or the anticipated sex related outcomes of use, have been shown to be predictors of substance use and sexual behavior respectively, though neither has been linked directly to sexual behavior and experience while experiencing the effects of marijuana.

    The current study explored the extent to which perceived social norms and sex-related expectancies predict participants’ reported sexual behaviors and experiences while feeling the effects of cannabis. Findings highlighted the relative frequency that participants reported engaging in oral, vaginal, and anal sex WEEC, and were consistent with much of the previous literature on the subjective effects, with most participants reporting increases in positive effects, such as desire and arousal, some reporting no change, and few reporting decreases.

    Of the identified predictors, enhancement and intimacy expectancies as well as descriptive social norms around cannabis use and sex WEEC were predictive of the general sexual behavior outcomes with main partners while only descriptive social norms around sex WEEC were predictive of the sexual risk behavior outcomes with casual partners.

    Enhancement expectancies were the most consistently significant predictor across subjective effects, with disinhibition, intimacy, and risk expectancies as well as descriptive social norms around cannabis use predicting fewer subjective effects.

    The results highlight potential educational and risk-reduction intervention points, and lend support to the sexual therapeutic potential of cannabis.

    Lindsay Lock. Stoned Sex: The Influence of Social Norms and Expectancies on Sex While Experiencing the Effects of Cannabis. A Dissertation Presented to the Faculty of the School of Human Service Professions Widener University In Partial Fulfillment of the Requirements for the Degree Doctor of Philosophy. Center for Human Sexuality Studies. May 2019. Stoned Sex: The Influence of Social Norms and Expectancies on Sex While Experiencing the Effects of Cannabis - ProQuest
     
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  8. Michael Scally MD

    Michael Scally MD Doctor of Medicine

    Kraft Heinz leads $23m investment in cannabis startup Flowhub
    Kraft Heinz leads $23m investment in cannabis startup Flowhub

    Kraft Heinz has made its first move into the cannabis sector, as its Evolv Ventures venture capital arm has co-led a $23 million funding round in cannabis technology startup Flowhub.

    Denver-headquartered Flowhub is a cannabis retail software company which delivers compliance, point of sale, inventory tracking and business intelligence data to cannabis dispensaries through a digital platform.

    Evolv Ventures was established by Kraft Heinz last year to invest in emerging tech companies that are “transforming the food industry”, and this investment is the third venture made by Evolv and its first in the cannabis tech sector.

    The overarching goal of the venture arm is to support Kraft Heinz’s efforts to keep on top of changing trends in the food and beverage industry, and CBD-infused products are gaining interest from consumers due to their perceived functional benefits.


    Kraft Heinz
    The Kraft Heinz Company
     
  9. Michael Scally MD

    Michael Scally MD Doctor of Medicine

     
    Seven likes this.
  10. Praeceptorem

    Praeceptorem Member

    Does anyone have a good recipe for thc syrup like for making hard candies and such?
     
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  11. Sworder

    Sworder Member

    I am not a big "weed" guy however I have been using it for sleep. There is so much talk about "strains" and I just buy whatever they have. I have not noticed a difference at all between the strains and I tend to have a pretty acute sense. So, I have been questioning the validity of strains for a while. I personally think it is all marketing.

    At least I do not think that the strains differ the way they make it seem. If the different strains were different I would assume they had different MOAs and receptor behavior. Just this article confirms my suspicion. However I want to learn more. If you guys have any information about "strains" please forward to me. I need to go through this thread still as well.



    An Overview of Products and Bias in Research
    https://link.springer.com/article/10.1007/s13311-015-0370-x

    Abstract
    Cannabis is a genus of annual flowering plant. Cannabis is often divided into 3 species—Cannabis sativa, Cannabis indica, and Cannabis ruderalis—but there is significant disagreement about this, and some consider them subspecies of the same parent species. Cannabis sativa can grow to 5–18 feet or more, and often has a few branches. Cannabis indica typically grows 2–4 feet tall and is compactly branched. Cannabis ruderalis contains very low levels of Δ-9-tetrahyocannabinol so is rarely grown by itself. Cannabis ruderalis flowers as a result of age, not light conditions, which is called autoflowering. It is principally used in hybrids, to enable the hybrid to have the autoflowering property. There are > 700 strains of cannabis, often with colorful names. Some are strains of 1 of the 3 subspecies. Many are crossbred hybrids. The strains can be named in a variety of ways: smell or lineage are common ways of naming. There are only a few rules about how the strains are named, and most strains’ names do not follow the rules. There are 4 basic preparations of marijuana: bhang, hasish, oil (or hash oil), and leaves and/or buds. In medical marijuana trials, subjective outcomes are frequently used but blind breaking can introduce significant bias. Blind breaking occurs when patients figure out if they are in the control or the treatment group. When this occurs, there is significant overestimation of treatment effect.
     
  12. Sdryx

    Sdryx Member

    I would equate it to something like wine. You have to develop a taste and a skill for noticing the subtle differences in these chemicals, much like a noob wine drinker wouldn’t understand why a bottle of wine goes for thousands of dollars. Similarly, give a newbie smoker any kind of weed and they all get “stoned” the same and it all tastes like burnt flowers the same. They may be able to tell the difference between dirt weed and the “good shit” but that’s about it.

    Keep smoking a specific strain consistently and you may find you start to like a particular strain better than a new strain that you try later.

    The best way to start is to start being consistent in knowing exactly what you are smoking each time by buying specific strains from a dispensary and not some random “bag of weed” from your dealer.

    We have a luxury nowadays where we can treat weed like top shelf alcohol. Don’t drink whatever shit you can find and mix together from your parents liquor cabinet like a kid just to get “drunk.” Go to a top dispensary and order the equivalent of your favorite well crafted top shelf mixed beverage!
     
  13. Sworder

    Sworder Member

    That's my main thing! I feel like I should have developed those subtle differences by now. I have been smoking for at least a year, I went to dabs pretty fast though. First I got some flower and then there was this crumble that I liked putting on the flower. That stuff hit hard. Then I just bought a dab rig because I figured it would be easier on my lungs as I don't like the smoke that much.

    I don't know, weed isn't my forte.

    I can tell differences in quality in regard to the wax that I buy. However I can't tell any differences between strains nor sativa or indica. So that's again my confusion, I have developed a sort of sensitivity to the "strength" however not to the "strains" or "sativa/indica." I am starting to believe it is a farce almost.

    Okay, this could be my problem. I mainly buy wax and it is different strains most the time. I could see how buying like a pound of flower and smoking that to really get familiar with it could help.

    I think I am going to go back to flower, or maybe lower the dose of the dabs.
     
    Sdryx likes this.
  14. Michael Scally MD

    Michael Scally MD Doctor of Medicine



    SMITHS FALLS, Ontario — The skunky, floral smell of growing marijuana is everywhere, from the parking lot outside the cavernous warehouse, to the lobby, even inside the coffee nook where employees take a break.

    The building itself is a chocolate brown box that once housed a Hershey’s candy factory. In just one wing, a labyrinth of white halls links seemingly endless rows of windowless rooms, some the size of a school gymnasium, with fields of cannabis inside growing under bright white and yellow lights.

    Workers wheel carts piled high with bales of green buds. In large open-floor production rooms, assembly lines of machinery pump out pot products, scores of perfectly rolled joints from the silver fingers of one, slews of red pills for medical marijuana patients in Germany spilling from another.

    Welcome to the Walmart of Weed.

    With Canada the largest nation to completely legalize marijuana, the world’s most valuable pot company, Canopy Growth Corp., has set up shop in this rural town seven hours northwest of Boston. Founded in 2013 and now worth about $6.4 billion, Canopy is one of the most watched and most controversial pot companies, the embodiment of Big Marijuana that critics contend uses size, market power, and lobbying prowess to accelerate the loosening of cannabis laws around the world and shoulder out competitors and smaller businesses.
     
  15. Michael Scally MD

    Michael Scally MD Doctor of Medicine

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  16. Michael Scally MD

    Michael Scally MD Doctor of Medicine

    [OA] Association Between Marijuana Use and Risk of Cancer

    Key Points

    Question What is the association between marijuana use and cancer development in adults with at least 1 joint-year exposure (equivalent to 1 joint per day for 1 year)?

    Findings This systematic review and meta-analysis identified 25 English-language studies assessing marijuana use and the risk for developing lung, head and neck, urogenital, and other cancers. In meta-analyses, regular marijuana use was associated with development of testicular germ cell tumors, although the strength of evidence was low; evidence regarding other cancers was insufficient.

    Meaning Sustained marijuana use may increase the risk for testicular cancer, but overall, the association of marijuana use and cancer development remains unclear.

    Ghasemiesfe M, Barrow B, Leonard S, Keyhani S, Korenstein D. Association Between Marijuana Use and Risk of Cancer: A Systematic Review and Meta-analysis. JAMA Netw Open. 2019;2(11):e1916318. Association Between Marijuana Use and Risk of Cancer

    Importance Marijuana use is common and growing in the United States amid a trend toward legalization. Exposure to tobacco smoke is a well-described preventable cause of many cancers; the association of marijuana use with the development of cancer is not clear.

    Objective To assess the association of marijuana use with cancer development.

    Data Sources A search of PubMed, Embase, PsycINFO, MEDLINE, and the Cochrane Library was conducted on June 11, 2018, and updated on April 30, 2019. A systematic review and meta-analysis of studies published from January 1, 1973, to April 30, 2019, and references of included studies were performed, with data analyzed from January 2 through October 4, 2019.

    Study Selection English-language studies involving adult marijuana users and reporting cancer development. The search strategy contained the following 2 concepts linked together with the AND operator: marijuana OR marihuana OR tetrahydrocannabinol OR cannabinoid OR cannabis; AND cancer OR malignancy OR carcinoma OR tumor OR neoplasm.

    Data Extraction and Synthesis Two reviewers independently reviewed titles, abstracts, and full-text articles; 3 reviewers independently assessed study characteristics and graded evidence strength by consensus.

    Main Outcomes and Measures Rates of cancer in marijuana users, with ever use defined as at least 1 joint-year exposure (equivalent to 1 joint per day for 1 year), compared with nonusers. Meta-analysis was conducted if there were at least 2 studies of the same design addressing the same cancer without high risk of bias when heterogeneity was low to moderate for the following 4 cancers: lung, head and neck squamous cell carcinoma, oral squamous cell carcinoma, and testicular germ cell tumor (TGCT), with comparisons expressed as odds ratios (ORs) with 95% CIs.

    Results Twenty-five English-language studies (19 case-control, 5 cohort, and 1 cross-sectional) were included; few studies (n = 2) were at low risk of bias. In pooled analysis of case-control studies, ever use of marijuana was not associated with head and neck squamous cell carcinoma or oral cancer.

    In pooled analysis of 3 case-control studies, more than 10 years of marijuana use (joint-years not reported) was associated with TGCT (OR, 1.36; 95% CI, 1.03-1.81; P = .03; I2 = 0%) and nonseminoma TGCT (OR, 1.85; 95% CI, 1.10-3.11; P = .04; I2 = 0%). Evaluations of ever use generally found no association with cancers, but exposure levels were low and poorly defined.

    Findings for lung cancer were mixed, confounded by few marijuana-only smokers, poor exposure assessment, and inadequate adjustment; meta-analysis was not performed for several outcomes.

    Conclusions and Relevance Low-strength evidence suggests that smoking marijuana is associated with developing TGCT; its association with other cancers and the consequences of higher levels of use are unclear. Long-term studies in marijuana-only smokers would improve understanding of marijuana’s association with lung, oral, and other cancers.
     
  17. Michael Scally MD

    Michael Scally MD Doctor of Medicine

     
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  18. The wifey picked up some Hemp products , didnt realize how much protein & Omega oils the seed hearts had . Sprinkled some on my cottage cheese/pineapple concoction . Taste good ! :D

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  19. Johne71

    Johne71 Member

     
  20. Venom82

    Venom82 Member

    Has anyone found a method to help remove thc for you system for a drug screen? None of that myth bullshit.