Marijuana [Cannabis]

[BBC3]

Re: Marijuana Question

I had a bro who used to love to "stone his pussy" back in the day. It would get him laid 10 out of 10 times. There is no question that the lack of inhibition that comes along with pot smoking leads to some awsome sex..! But I swear every time I have thought about it, I think they must have just yielded to him due to too paranoid to say no... LOL

But that really begs an interesting point. BOTH alcohol and Marijuana ellicit a "loss or reduction of inhibition", yet the one that comes with alcohol causes brass ball stupid behavior, and the one associated with pot is more of a peaceful action resulting and usually centered around the frige and the TV.. LOL

 

[leoclaw79]

Re: Marijuana Question

whew dr. scally, im glad i didnt start smoking weed until after high school, my step brother on the other hand started smoking in his adolescent years and it seems to have effected him almost certainly. stone the pussy!!

 

[mac111]

Re: Marijuana Question

Fuckin brain rot, wasted a lot of my youth with rec drugs. A fuckin mugs game....

 

[Michael Scally MD]

Re: Marijuana Question

Lacson JCA, Carroll JD, Tuazon E, Castelao EJ, Bernstein L, Cortessis VK. Population-based case-control study of recreational drug use and testis cancer risk confirms an association between marijuana use and nonseminoma risk. Cancer. Population-based case-control study of recreational drug use and testis cancer risk confirms an association between marijuana use and nonseminoma risk - Lacson - 2012 - Cancer - Wiley Online Library

BACKGROUND: Testicular germ cell tumor (TGCT) incidence increased steadily in recent decades, but causes remain elusive. Germ cell function may be influenced by cannabinoids, and 2 prior epidemiologic studies reported that the use of marijuana may be associated with nonseminomatous TGCT. Here, the authors evaluate the relation between TGCTs and exposure to marijuana and other recreational drugs using a population-based case-control study.

METHODS: In total, 163 patients who were diagnosed with TGCT in Los Angeles County from December 1986 to April 1991 were enrolled, and 292 controls were matched on age, race/ethnicity, and neighborhood. Participants were asked about drug use by a structured, in-person interview. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using conditional logistic regression analysis adjusted for history of cryptorchidism; education; religiosity; and reported use of marijuana, cocaine, and amyl nitrite.

RESULTS: Compared with never use, ever use of marijuana had a 2-fold increased risk (OR, 1.94; 95% CI, 1.02-3.68), whereas ever use of cocaine had a negative association with TGCT (OR, 0.54; 95% CI, 0.32-0.91). Stratification on tumor histology revealed a specific association of marijuana use with nonseminoma and mixed histology tumors (OR, 2.42; 95% CI, 1.08-5.42).

CONCLUSIONS: A specific association was observed between marijuana use and the risk of nonseminoma and mixed tumors. To the authors' knowledge, this is the first report of a negative association between cocaine use and TGCT risk. The current results warrant mechanistic studies of marijuana's effect on the endocannabinoid system and TGCT risk and caution that recreational and therapeutic use of cannabinoids by young men may confer malignant potential to testicular germ cells.

 

[lntense]

Re: Bill Roberts marijuana question

Vaporizer or edibles. Then you dont have to smoke it, much more healthy

 

[Michael Scally MD]

Re: Marijuana Question

Allsop DJ, Copeland J, Norberg MM, et al. Quantifying the Clinical Significance of Cannabis Withdrawal. PLoS ONE 2012;7(9):e44864. PLOS ONE: Quantifying the Clinical Significance of Cannabis Withdrawal

Background and Aims - Questions over the clinical significance of cannabis withdrawal have hindered its inclusion as a discrete cannabis induced psychiatric condition in the Diagnostic and Statistical Manual of Mental Disorders (DSM IV). This study aims to quantify functional impairment to normal daily activities from cannabis withdrawal, and looks at the factors predicting functional impairment. In addition the study tests the influence of functional impairment from cannabis withdrawal on cannabis use during and after an abstinence attempt.

Methods and Results - A volunteer sample of 49 non-treatment seeking cannabis users who met DSM-IV criteria for dependence provided daily withdrawal-related functional impairment scores during a one-week baseline phase and two weeks of monitored abstinence from cannabis with a one month follow up. Functional impairment from withdrawal symptoms was strongly associated with symptom severity (p = 0.0001). Participants with more severe cannabis dependence before the abstinence attempt reported greater functional impairment from cannabis withdrawal (p = 0.03). Relapse to cannabis use during the abstinence period was associated with greater functional impairment from a subset of withdrawal symptoms in high dependence users. Higher levels of functional impairment during the abstinence attempt predicted higher levels of cannabis use at one month follow up (p = 0.001).

Conclusions - Cannabis withdrawal is clinically significant because it is associated with functional impairment to normal daily activities, as well as relapse to cannabis use. Sample size in the relapse group was small and the use of a non-treatment seeking population requires findings to be replicated in clinical samples. Tailoring treatments to target withdrawal symptoms contributing to functional impairment during a quit attempt may improve treatment outcomes.

 

[Dr JIM]

Re: Marijuana Question

Yea but I have caffeine "withdrawal" when I dont get my "daily Joe". Perhaps I should be admitted to a rehab facility for thirty days to ensure I don't relapse
should I decide to "quit", lol.

 

[Michael Scally MD]

Re: Marijuana Question

Pot smokers might not turn into dopes after all
Revisiting data casts doubts on link between heavy cannabis use and declining IQ.
Pot smokers might not turn into dopes after all : Nature News & Comment


Rogeberg O. Correlations between cannabis use and IQ change in the Dunedin cohort are consistent with confounding from socioeconomic status. Proceedings of the National Academy of Sciences. Correlations between cannabis use and IQ change in the Dunedin cohort are consistent with confounding from socioeconomic status

Does cannabis use have substantial and permanent effects on neuropsychological functioning? Renewed and intense attention to the issue has followed recent research on the Dunedin cohort, which found a positive association between, on the one hand, adolescent-onset cannabis use and dependence and, on the other hand, a decline in IQ from childhood to adulthood [Meier et al. (2012) Proc Natl Acad Sci USA 109(40):E2657–E2664]. The association is given a causal interpretation by the authors, but existing research suggests an alternative confounding model based on time-varying effects of socioeconomic status on IQ. A simulation of the confounding model reproduces the reported associations from the Dunedin cohort, suggesting that the causal effects estimated in Meier et al. are likely to be overestimates, and that the true effect could be zero. Further analyses of the Dunedin cohort are proposed to distinguish between the competing interpretations. Although it would be too strong to say that the results have been discredited, the methodology is flawed and the causal inference drawn from the results premature.

 

[Dr JIM]

Re: Marijuana Question

It does compel those whom are inherently lazy to pursue otiose undertakings which may eventually lower self esteem and result in a disinterest in acquiring a formal education.

However since IQ, no doubt, is a integrative neurochemical process physiologically, I can't appreciate HOW THC would adversely effect IQ.

After all in those long term studies evaluating the biochemical alterations from abuse, NO remarkable differences have been noted, (in WELL controlled trials), involving researchers whom are not of a particular personal, political, or religious persuasion.

Fact is mankind legalized THE WRONG STUFF, IMO!

Jim

 

[Mike Oxbig]

Re: Marijuana Question

My only qualm with my marijuana use was the age I started; I smoked daily from age 14 through 21. I still would smoke(albeit far less frequently) if it didn't jeopardize my career/pension, cannabis is superior to alcohol in about every way possible.

 

[Dr JIM]

Re: Marijuana Question

I absolutely agree although relatively benign, smoking before age 21 or at least graduating high school is not a good idea!

 

[Pericles]

Re: Bill Roberts marijuana question

It's called will power :/

Actually, no, it is called an addiction which has nothing to do w/ will power. I am not judging others, but if I took a drink, all the willpower in the world would not matter. The only power I have is over the first drink or drug.

Will power comes in when you have comitted to a program to treat your adiction.

Pot is less harmfull to BBers than booze, but pot will miraculously have you moving back into your parents' basement.

 

[Pericles]

Re: Bill Roberts marijuana question

Yes I must admit that it would be hard to imagine anyone smoking more than I did from age 17 to age 30 something. I played college sports, and ran a 4.40 40 at 6' 225lbs

I also have a 4.0 GPA MBA

I am able to lift (although I do believe that some sort of toll has been taken on my lungs...not like cancer...just kind of out of breath until I can work through it to get myself back into cardio shape)

One huge mistake is takin a toke and then tryin to work out. You will be out of breath. You will be almost too relaxed to work hard enough. Now when I bucked hay bales for over a decade (these are three string 135lb to 145lb average timothy bales) we would easily move 100 to 200 tons per day. In order to do that kind of work we got all toked up and it actually helped.

Sweat a gallon every few hours, moving fast, and breathing very hard...all while lifting, twisting, pulling , pushing, and stacking. All the hay bucks i knew smoked and they dont have lung problems.

I you are going to smoke a vaporizer is great, so is makin brownies, but do it on your day off, and be prepared to work to make up for the play time. I actually believe a little herb helps me relax and heal, and that the lung problems are not noticed.

-billy

Old post but I can't resist: 4.4 40 in college, 4.0 gpa in an MBA program (online?), and your employment is moving bales of hay.

Pretty strong anti-drug message there.

 

[Dr JIM]

Re: Marijuana Question

There are responsible marijuana and ETOH users yet very few are less than 21yrs, IME!

However, some folk just can not drink or use any REC without abusing it!

I commend and compliment you for conquering the daily challenges you confront PC, and thank goodness you understand the colloquialism; "a mans got to know his limitations"!

JIM

 

[Pericles]

Re: Marijuana Question

There are responsible marijuana and ETOH users yet very few are less than 21yrs, IME!

However, some folk just can not drink or use any REC without abusing it!

I commend and compliment you for conquering the daily challenges you confront PC, and thank goodness you understand the colloquialism; "a mans got to know his limitations"!

JIM

Absolutely. I was a very dangerous and mean drunk. Killed my dad (age 36, I was 10) and pills and Vodka killed my mom.

I was addicted to every drug possible, and finally it was pot (15 years and almost 8 months ago). I started on pot at the age of 13 and was a daily smoker for many many years. What happened is that I did not develop emotionally as a result.

Admittedly, pot is, IMO, the least dangerous among recs, and less dangerous than Alcohol.

The problem was that I needed to be stoned all the time as opposed to developing the ability to live life on life's terms.

I don't judge others, they may well be able to smoke a little pot now and then. I can't, and I am fine with that.

 

[Dr JIM]

Re: Marijuana Question

On spot mate!

 

[idmd]

Marijuana Question

Between the ages of 13-19 I smoked A LOT of pot. My first year of college was not great but then I decided to get serious. I stopped smoking pot and started working hard and my second through fourth year of college I had a 4.0 GPA while double majoring in bio and chem. Nothing like taking organic chem 2, calc based physics 2, advanced inorganic chem, differential equations and advanced molecular techniques all in the same semester - I was the kid who the prof had to eliminate my score from calculating the passing grade to get the rest of the class to pass.

None of that would've been possible smoking weed. While I have no substance abuse problems now and it's ability to act like a gateway drug is always touted as its really negative effect....you can smoke enough to induce pathological apathy and to impair short term memory enough to effect life.

 

[Dr JIM]

Re: Marijuana Question

Odd, the overwhelming majority of successful people "stopped smoking pot"!

 

[Pericles]

Re: Marijuana Question

Odd, the overwhelming majority of successful people "stopped smoking pot"!

Correct. An important difference between heavy users and true addicts is that heavy users recognize that they are following a path to destruction and thus stop using.

For those of us that crossed the line between heavy user/drinker, we became true addicts/alcoholics. There is no turning back. It is like a pickle, it will never be a cucumber again.. I like to say it is alcoholism, not alcohol-was'm. If I picked up again I would probably be dead w/ in a few years. Death does not really scare me, it is the hell I would be in before death. I also need to stay around long enough for my son (5 years old) to fully grow up.

 

[Michael Scally MD]

Re: Marijuana Question

Muniyappa R, Sable S, Ouwerkerk R, et al. Metabolic Effects of Chronic Cannabis Smoking. Diabetes Care. Metabolic Effects of Chronic Cannabis Smoking

OBJECTIVE We examined if chronic cannabis smoking is associated with hepatic steatosis, insulin resistance, reduced ?-cell function, or dyslipidemia in healthy individuals.

RESEARCH DESIGN AND METHODS In a cross-sectional, case-control study, we studied cannabis smokers (n = 30; women, 12; men, 18; 27 ± 8 years) and control subjects (n = 30) matched for age, sex, ethnicity, and BMI (27 ± 6). Abdominal fat depots and intrahepatic fat content were quantified by magnetic resonance imaging and proton magnetic resonance spectroscopy, respectively. Insulin-sensitivity indices and various aspects of ?-cell function were derived from oral glucose tolerance tests (OGTT).

RESULTS Self-reported cannabis use was: 9.5 (2–38) years; joints/day: 6 (3–30) [median (range)]. Carbohydrate intake and percent calories from carbohydrates, but not total energy intake, were significantly higher in cannabis smokers. There were no group differences in percent total body fat, or hepatic fat, but cannabis smokers had a higher percent abdominal visceral fat (18 ± 9 vs. 12 ± 5%; P = 0.004). Cannabis smokers had lower plasma HDL cholesterol (49 ± 14 vs. 55 ± 13 mg/dL; P = 0.02), but fasting levels of glucose, insulin, total cholesterol, LDL cholesterol, triglycerides, or free fatty acids (FFA) were not different. Adipocyte insulin resistance index and percent FFA suppression during an OGTT was lower (P < 0.05) in cannabis smokers. However, oral glucose insulin sensitivity index, measures of ?-cell function, or incretin concentrations did not differ between the groups.

CONCLUSIONS Chronic cannabis smoking was associated with visceral adiposity and adipose tissue insulin resistance but not with hepatic steatosis, insulin insensitivity, impaired pancreatic ?-cell function, or glucose intolerance.