Marijuana [Cannabis]

Re: Marijuana Question

[Ignoramus Buffoon] O'Reilly Goes Ballistic Over Denver Post Hiring Pot Editor: They're 'Promoting Intoxication!'
[ame=http://www.youtube.com/watch?v=jhDj8qFyXF0]O'Reilly Goes Ballistic Over Denver Post Hiring Pot Editor: They're 'Promoting Intoxication!' - YouTube[/ame]
 
Re: Marijuana Question

Uruguay set to become first country to legalize marijuana trade
http://www.reuters.com/article/2013/12/10/us-uruguay-marijuana-idUSBRE9B905A20131210

(Reuters) - Uruguay's Senate is expected to pass a law on Tuesday making the small South American nation the world's first to allow its citizens to grow, buy and smoke marijuana.

The pioneering government-sponsored bill establishes state regulation of the cultivation, distribution and consumption of marijuana and is aimed at wresting the business from criminals.

Cannabis consumers would be allowed to buy a maximum of 40 grams (1.4 ounces) each month from state-regulated pharmacies as long as they are over the age of 18 and registered on a government database that will monitor their monthly purchases.

Uruguayans would also be allowed to grow up to six plants of marijuana in their homes a year, or as much as 480 grams (about 17 ounces). They could also set up smoking clubs of 15 to 45 members that could grow up to 99 plants per year.

The bill, which opinion polls show is unpopular, passed the lower chamber of Congress in July and is expected to easily pass the Senate on the strength of the ruling coalition's majority.

Uruguay's attempt to undo drug trafficking is being followed closely in Latin America where the legalization of some narcotics is being increasingly seen by regional leaders as a possible way to end the violence spawned by the cocaine trade.
 
Re: Bill Roberts marijuana question

i smoke (vape only though) quite often. sometimes i take long breaks.

cardio is definitely affected, and it is not because of the lungs. it is because of your brain. marijuana lowers dopamine, and increases prolactin as a result. the prolactin is not the culprit for the shortness of breath, but it can exacerbate gyno ESPECIALLY DURING POST CYCLE!

i highly recommend not smoking at all during post cycle, and maybe a bit after.

the lowered dopamine means decreased motivation and intensity. you just feel more tired. often i question if smoking weed is worth it at all.

lol
 
Re: Bill Roberts marijuana question

however, i do smoke preworkout occasionally, and i really enjoy high rep movements like calves, lateral raises, shrugs while high. it takes some pain out of the burn. this works better on cycle though. lol
 
Re: Marijuana Question

Nothing WRONG with a swig (or two, three, four, etc) from the bottle either, or so many believe!

Nothing wrong with most drugs as long as they are used rather than abused and the most appropriate term for the former, MODERATION!

A behavior MANY are unable to master regardless of the "pleasureful fruit" selected!
 
Re: Marijuana Question

Too many news outlets focus on the "intoxicant" aspect of weed and not the numerous health benefits. I was constantly poisoning my liver for years with naproxen and Vicodin (both prescribed by my doc), which just masked the pain and never made any improvements. If my back is bothering me I'll take one small hit of pot before bed and I'll sleep full 8 (before I would sleep 5-6) with almost zero pain. It's a shame it's demonized in so many circles because it's a pretty amazing substance.
 
Re: Marijuana Question

Numerous health benefits, NOT!

There are no benefits to THC that are not readily achieved by existing medications on the market today.

That notion is nothing more than a ruse propped by that sector of the population whom are making attempts to legalize marihuana!

The fact is if legalized Marihuana will need to be controlled just like ETOH, although it's potential for "abuse" is minimal when compared to alcohol.

But based on my experience the former and the latter both exacerbate laziness in the lazy, something we have plenty of in this country, IME
 
Marijuana Question

That's an extremely ignorant and ill informed stance. From NY times:

"There is evidence that several common disorders, including epilepsy, alcoholism and post-traumatic stress disorder, involve disruptions in the endocannabinoid system, suggesting that those patients might benefit from marijuana or its ingredients.

The strongest evidence for the health benefits of medical marijuana or its derivatives involves the treatment of chronic neuropathic pain and the spasticity caused by multiple sclerosis. Medical marijuana is widely recognized as effective against nausea and appetite loss caused by chemotherapy, although better treatments are now available. But preliminary research and anecdotal reports have suggested that marijuana might be useful in treating a number of other conditions, including irritable bowel syndrome, Crohn’s disease, glaucoma, migraine, cancer growth, abnormal heart rhythms, Alzheimer’s disease, fibromyalgia, incontinence, bacterial infections, osteoporosis, intense itching, Tourette’s syndrome and sleep apnea."

I found that in 30 seconds just to prove a point, but there are hundreds of studies showing similar promise. Can it be abused? Of course, but so can almost any other substance. And while there may be other substances to treat these conditions, many are addictive, toxic, or not as effective.
 
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Re: Marijuana Question

Medical marihuana is it helpful for certain condition in select patients sure, BUT it is no more beneficial than existing medications alone OR IN combination, NOT!

You have any study that PROVES otherwise POST IT! (The "study" would have to be a "double arm crossover" analysis and compare the ability of THC (marihuana) VS another approved antiemetic such as Zofran for instance)

Moreover because THC is often associated with a heightened sense of awareness, at least for the first 30-60 minutes, it may actually worsen neuropathic pain in some patients.

Hey don't get me wrong Im all for decriminalizing or even legalizing the stuff especially if controlled appropriately, BUT medical marihuana is NOT my reasoning at all.

Fact is it's a very safe recreational drug, much safer than alcohol by far!

Wanna drive like granny smoke some, lol!
 
Re: Marijuana Question

Medical marihuana is it helpful for certain condition in select patients sure, BUT it is no more beneficial than existing medications alone OR IN combination, NOT!



You have any study that PROVES otherwise POST IT! (The "study" would have to be a "double arm crossover" analysis and compare the ability of THC (marihuana) VS another approved antiemetic such as Zofran for instance)



Moreover because THC is often associated with a heightened sense of awareness, at least for the first 30-60 minutes, it may actually worsen neuropathic pain in some patients.



Hey don't get me wrong Im all for decriminalizing or even legalizing the stuff especially if controlled appropriately, BUT medical marihuana is NOT my reasoning at all.



Fact is it's a very safe recreational drug, much safer than alcohol by far!



Wanna drive like granny smoke some, lol!


Good points. The unfortunate part is that since it's schedule 1 there have been very few proper studies done in the US. Most have been done by anti-drug groups which obviously are subject to strong confirmation bias. Much of THC's touted benefits are based off of large amounts of anecdotal evidence, and even though the subject pool is huge and the results are somewhat uniform there's no way to control the variables enough to unequivocally say "THC cures/aids in ___".
 
Re: Marijuana Question

Good points. The unfortunate part is that since it's schedule 1 there have been very few proper studies done in the US. Most have been done by anti-drug groups which obviously are subject to strong confirmation bias. Much of THC's touted benefits are based off of large amounts of anecdotal evidence, and even though the subject pool is huge and the results are somewhat uniform there's no way to control the variables enough to unequivocally say "THC cures/aids in ___".

Considering the number of active constituents of marijuana, it seems likely to me that it could offer potential treatments, particularly for mental illness, provided research continues. Current research on cannabinoids and schizophrenia is showing some interesting results. Cannabidiol, a non-psychoactive cannabinoid is showing promise as an antipsychotic with the ability to ameliorate symptoms of schizophrenia, including negative symptoms. This is even more interesting because it's been long held that marijuana induces psychosis in schizophrenics, however, at least some are now questiong that belief. More research is needed because this is an area where psychopharmacologists have a limited armamentarium.

Drug Test Anal. 2013 Jan;5(1):46-51. doi: 10.1002/dta.1425. Epub 2012 Oct 25.
Medical use of cannabis. Cannabidiol: a new light for schizophrenia?Medical use of cannabis. Cannabidiol: a new l... [Drug Test Anal. 2013] - PubMed - NCBI
Deiana S.

Abstract

The medical properties of cannabis have been known for many centuries; its first documented use dates back to 2800 BC when it was described for its hallucinogenic and pain-relieving properties. In the first half of the twentieth century, a number of pharmaceutical companies marked cannabis for indications such as asthma and pain, but since then its use has sharply declined, mainly due to its unpredictable effects, but also for socio-political issues. Recently, great attention has been directed to the medical properties of phytocannabinoids present in the cannabis plant alongside the main constituent ??-Tetrahydrocannabinol (THC); these include cannabinoids such as cannabidiol (CBD), cannabigerol (CBG), and tetrahydrocannabivarin (THCV). Evidence suggests an association between cannabis and schizophrenia: schizophrenics show a higher use of marijuana as compared to the healthy population. Additionally, the use of marijuana can trigger psychotic episodes in schizophrenic patients, and this has been ascribed to THC. Given the need to reduce the side effects of marketed antipsychotics, and their weak efficacy on some schizophrenic symptoms, cannabinoids have been suggested as a possible alternative treatment for schizophrenia. CBD, a non-psychoactive constituent of the Cannabis sativa plant, has been receiving growing attention for its anti-psychotic-like properties. Evidence suggests that CBD can ameliorate positive and negative symptoms of schizophrenia. Behavioural and neurochemical models suggest that CBD has a pharmacological profile similar to that of atypical anti-psychotic drugs and a clinical trial reported that this cannabinoid is a well-tolerated alternative treatment for schizophrenia.


Curr Pharm Des. 2013 Jun 14.
Cannabinoids and Schizophrenia: Therapeutic Prospects.Cannabinoids and Schizophrenia: Therapeutic P... [Curr Pharm Des. 2013] - PubMed - NCBI
Robson PJ, Guy GW, Di Marzo V.

Abstract

Approximately one third of patients diagnosed with schizophrenia do not achieve adequate symptom control with standard antipsychotic drugs (APs). Some of these may prove responsive to clozapine, but non-response to APs remains an important clinical problem and cause of increased health care costs. In a significant proportion of patients, schizophrenia is associated with natural and iatrogenic metabolic abnormalities (obesity, dyslipidaemia, impaired glucose tolerance or type 2 diabetes mellitus), hyperadrenalism and an exaggerated HPA response to stress, and chronic systemic inflammation. The endocannabinoid system (ECS) in the brain plays an important role in maintaining normal mental health. ECS modulates emotion, reward processing, sleep regulation, aversive memory extinction and HPA axis regulation. ECS overactivity contributes to visceral fat accumulation, insulin resistance and impaired energy expenditure. The cannabis plant synthesises a large number of pharmacologically active compounds unique to it known as phytocannabinoids. In contrast to the euphoric and pro-psychotic effects of delta-9-tetrahydrocannabinol (THC), certain non-intoxicating phytocannabinoids have emerged in pre-clinical and clinical models as potential APs. Since the likely mechanism of action does not rely upon dopamine D2 receptor antagonism, synergistic combinations with existing APs are plausible. The anti-inflammatory and immunomodulatory effects of the non-intoxicating phytocannabinoid cannabidiol (CBD) are well established and are summarised below. Preliminary data reviewed in this paper suggest that CBD in combination with a CB1 receptor neutral antagonist could not only augment the effects of standard APs but also target the metabolic, inflammatory and stress-related components of the schizophrenia phenotype.



Schizophr Res. 2013 Dec 2. pii: S0920-9964(13)00610-5. doi: 10.1016/j.schres.2013.11.014. [Epub ahead of print]
A controlled family study of cannabis users with and without psychosis.
A controlled family study of cannabis users wi... [Schizophr Res. 2013] - PubMed - NCBI
Proal AC, Fleming J, Galvez-Buccollini JA, Delisi LE.


Abstract

BACKGROUND: Cannabis is one of the most highly abused illicit drugs in the world. Several studies suggest a link between adolescent cannabis use and schizophrenia. An understanding of this link would have significant implications for legalization of cannabis and its medicinal value. The present study aims to determine whether familial morbid risk for schizophrenia is the crucial factor that underlies the association of adolescent cannabis use with the development of schizophrenia.

METHODS: Consecutively obtained probands were recruited into four samples: sample 1: 87 non-psychotic controls with no drug use; sample 2: 84 non-psychotic controls with cannabis use; sample 3: 32 patients with a schizophrenia spectrum psychosis with no drug use; sample 4: 76 patients with schizophrenia spectrum psychosis with cannabis use. All cannabis using subjects used this drug during adolescence, and no other substance, with the exception of alcohol. Structured interviews of probands and family informants were used to obtain diagnostic information about probands and all their known relatives.

RESULTS: There was an increased morbid risk for schizophrenia in relatives of the cannabis using and non-using patient samples compared with their respective non-psychotic control samples (p=.002, p<.001 respectively). There was no significant difference in morbid risk for schizophrenia between relatives of the patients who use or do not use cannabis (p=.43).

CONCLUSIONS: The results of the current study suggest that having an increased familial morbid risk for schizophrenia may be the underlying basis for schizophrenia in cannabis users and not cannabis use by itself.
 
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Re: Marijuana Question

Party pooper CBS! That's all this country needs is MORE "stoned schizophrenics"
:)
 
Re: Marijuana Question

Party pooper CBS! That's all this country needs is MORE "stoned schizophrenics"
:)

Not trying to be a party pooper - those studies aren't good news for "medical marijuana" advocates or pot smokers since the cannabinoid showing promise is supposed to be non-psychoactive and most likely administered orally. The stoners hate that for some reason.:eek:
 
Re: Marijuana Question

Uruguay Marijuana Ruling 'Illegal'? UN Agency Says Decision Violates International Law
Uruguay Marijuana Ruling 'Illegal'? UN Agency Says Decision Violates International Law

Uruguay's move to legalise the production and sale of marijuana breaks international law, the world drugs body said Wednesday, warning it would encourage addiction.

"Uruguay is breaking the international conventions on drug control with the cannabis legislation approved by its congress," said the International Narcotics Control Board, a UN agency that oversees the implementation of international treaties on drugs.
 
IMO, this is potentially very big news. The WORLD will be watching. This will happen everywhere. And, horror of all horrors, there will be much less adverse effects than ETOH with added revenue, decreased prison population, and less crime.

Uruguay: Marijuana Becomes Legal
http://www.nytimes.com/2013/12/25/world/americas/uruguay-marijuana-becomes-legal.html

President José Mujica has quietly signed into law the government’s plan to create a regulated, legal market for marijuana, the president’s spokesman said Tuesday. The presidential secretary Diego Canepa said Mr. Mujica signed the legislation on Monday night. That was the last formal step for the law to take effect. Officials now have until April 9 to write the fine print for regulating every aspect of the marijuana market, from growing to selling in a network of pharmacies. They hope to have the whole system in place by the middle of next year. But as of Tuesday, growing marijuana at home was legal, up to six plants per family and an annual harvest of 480 grams, or about one pound.
 
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