it is high in the general scheme of things... But its not unmanageable.
If you getting bloods done, having some cruise periods in between the blasts, Personally, I think those AAS dosages are manageable for someone taking a serious shot (each person IS different however!)
Would I expect someone to have issues if they went straight to a 4,000mg/wk cycle.... You bet! They haven't learned their bodies signals to make changes on the fly to stop issues before they really start.
Insulin carries some risks, that's 100iu/d min he is using.
Now, if he is just blasting full time, 100% there is going to come a time to pay a price. You body just can't maintain turbo indefinitely.
Where I had issues become apparent REALLY quickly was went on a bender and got into rec's for 12mths.... Body was able to handle the PED's but rec's were the straw that broke the camels back! Everyone's bodies are different and everyone has a personal tolerance, exceed that and your body will let you know real quick!