Found this:
COMPARING BERBERINE VS METFORMIN
When you look at it from a cellular level,
both Metformin and Berberine work in a similar way. Both compounds create an environment that encourages healthy blood sugar levels. Both compounds work to enhance the
action of the AMPK enzyme, which is usually triggered during fasted states or when you’re engaged in intense exercise.
When AMPK is activated, there’s a higher uptake of fatty acids and glucose from the blood, the storage of fat and glucose is halted, and your cells have access to more energy.
AMPK facilitates quick and long-lasting results by immediately phosphorylating enzymes as well as their transcription factors.
Metformin facilitates faster cellular energy uptake just as well as Berberine, and this, in turn, facilitates the processing of energy storage.
When AMPK is triggered, it stimulates the transportation chain of electrons which promotes glucose consumption. Both compounds have the ability to specifically hinder complex 1 which belongs to the electron transport chain. This reduces the efficiency of the AP production process which your body interprets as being on a fasted state or a restricted calorie diet.
It’s important to note here that there currently isn’t enough evidence to show how the action mechanism of these compounds works but available research does show that Berberine reduces LDL cholesterol which is the harmful kind of cholesterol. On the other hand, Metformin
reduces the amount of triglycerides, LDL cholesterol and fatty acid levels in your body.
IS IT OKAY TO TAKE BOTH METFORMIN AND BERBERINE AT THE SAME TIME?
Evidence shows that these two compounds are actually complementary.
According to research done on mice, Berberine can actually promote healthy lactic acid levels when used in conjunction with Metformin.
In a nutshell, when comparing Berberine vs Metformin they have more things in common than they have differences.
Sure they may affect your body in different ways but they pretty much work on the same metabolic pathways, which is why it’s often recommended to use them in combination if your intention is to achieve physical longevity.
USING BERBERINE AND METFORMIN
Metformin and Berberine are undoubtedly the most prominent
geroprotectors on the market. Although they’re famous for promoting longevity and optimal health, there’s no conclusive evidence to fully support these claims.
Metformin is a prescription drug that you can only get through the recommendation of your doctor.
Berberine, on the other hand, is an over-the-counter drug that’s relatively easy and affordable to access. However, it’s still a good idea to consult with your physician before you purchase it.
When looking for a Berberine supplement to purchase, be sure to check its absorption rate and make sure that you’re buying it from a company that gets it from reputable manufacturers and suppliers.