MESO-Rx Exclusive Ozempic and Mounjaro for bodybuilders - more than just weight loss drugs

[MESO-Rx Administrator]

@Type-IIx explains the benefits of GLP-1 and GIP agonists like Semaglutide and Tirzepatide, as true insulin sensitizing agents. how they are different from other weight loss drugs, and the benefits as partitioning agents for bodybuilders.

I'm sure you've read a lot about Ozempic, Wegovy, and Mounjaro for overweight sedentary people in the mainstream media but if you want to read about the use of these drug from a bodybuilding perspective, read on:

Semaglutide and Tirzepatide are More Than Just Weight Loss Drugs

Learn how GLP-1 and GIP agonists like Semaglutide and Tirzepatide enhance insulin sensitivity, preserve muscle mass and reduce fat stores.

thinksteroids.com

 

[Type-IIx]

It is time. Release the book.

View attachment 276605

ETA I can now say is a matter of weeks (optimistically). The quality binding and form factor that I want is more expensive than anticipated, but I'll get this book out in a quality form ASAP.

 

[UncleBuns]

Didn't run out of ideas I redacted my practical applications because I like getting paid.

You mean to tell me when you get bills you don't link them to your online contributions and they call it even?

 

[Type-IIx]

You mean to tell me when you get bills you don't link them to your online contributions and they call it even?

It's fucked up. World isn't even fair, bro. I bet my contributions on here wouldn't even get me laid by a 7.

 

[AlexDavis43]

It's fucked up. World isn't even fair, bro. I bet my contributions on here wouldn't even get me laid by a 7.

Come on bro I'm at least a 7.5

 

[detroba]

I was thinking of hopping on Ozempic but I could not decide whether or not clen was a better option. Anyone with experience in either, thoughts?

 

[Musmadar]

I was thinking of hopping on Ozempic but I could not decide whether or not clen was a better option. Anyone with experience in either, thoughts?

Semaglutide better than clen...every time.

 

[BigJ1]

I have some serious studying to do.

 

[Underworld]

I have some serious studying to do.

Read Chapter 11 of the book "The Diabetic Code". Some people in this thread don't know what the fuck they're talking about lol

 

[Captainpotatohead]

how long do you suggest taking a break for when both start losing effectiveness ?

 

[Fat]

Does Sema/Tirz inhibit mtor/igf like metformin? is it pointless to use metformin when using Sema/Tirz? Thanks

 

[PushPullPl8s]

Hey @Type-IIx , if you had to personally choose - would you choose to use semaglutide or tirzapatide?


I'm curious from a binge eating disorder standpoint as I've heard that sema can be effective for some at reducing impulsive behaviours/addictions such as alcohol, food, etc.

Thank you for all the information you provide

 

[Type-IIx]

Hey @Type-IIx , if you had to personally choose - would you choose to use semaglutide or tirzapatide?


I'm curious from a binge eating disorder standpoint as I've heard that sema can be effective for some at reducing impulsive behaviours/addictions such as alcohol, food, etc.

Thank you for all the information you provide

For bodybuilding I’ve observed semaglutide to be slightly superior. This is because it is more (a) appetite suppressive, and (b) commercially available, particularly applicable to non-US residents in my experience.

Finally, and perhaps most importantly, GIP functions in fat cells to increase fat accrual. [1].

From [1]: "In adipose tissue, GIP has been reported to (1) stimulate fatty acid synthesis, (2) enhance insulin-stimulated incorporation of fatty acids intotriglycerides, (3) increase insulin receptor number, and (4) increase sensitivity of insulin-stimulated glucose transport."

"With that in mind, the following hypothesis may be proposed: individuals with a condition of increased GIP responsiveness may be more prone to obesity and hyperinsulinemia. Increased GIP responsiveness may manifest itself in the form of either increased affinity for GIP by GIP receptors, increased GIP receptor number, or increased synthesis and secretion of GIP following normal meal stimulation. The increased GIP responsiveness would likely increase insulin release resulting in greater and prolonged hyperinsulinemia. To compound this abnormality, GIP can also increase the affinity of the insulin receptor for insulin as well as increase the insulin-like effects in fat cells, all of which may serve to increase efftciency in the accumulation of triglycerides in fat cells. Thus, anecdotal accounts of individuals accumulating fat tissue mass at greater rates under normal meal conditions maybe a consequence of increased GIP responsiveness. Such individuals have greater efficiency in fat storage as a result of increased GIP and insulin responses when compared with normal persons." [1].

See also, the following Diagram from [2]:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354517/bin/touchendo-18-10-g001.jpg

References
[1] Yip RG, Wolfe MM. GIP biology and fat metabolism. Life Sci. 2000;66(2):91-103. doi:10.1016/s0024-3205(99)00314-8
[2] Kaneko S. Tirzepatide: A Novel, Once-weekly Dual GIP and GLP-1 Receptor Agonist for the Treatment of Type 2 Diabetes. touchREV Endocrinol. 2022 Jun;18(1):10-19. doi: 10.17925/EE.2022.18.1.10. Epub 2022 Jun 16. PMID: 35949358; PMCID: PMC9354517.

 

[PushPullPl8s]

@Type-IIx

Does semaglutide inheritly improve insulin sensitivity?

For those who experience a reduced desire for their addictions such as alcohol, smoking, etc - is there any direct cause from a GLP-1 agonist?

Thanks again for all the information!

 

[Type-IIx]

@Type-IIx

Does semaglutide inheritly improve insulin sensitivity?

For those who experience a reduced desire for their addictions such as alcohol, smoking, etc - is there any direct cause from a GLP-1 agonist?

Thanks again for all the information!

It does! It couples insulin secretion to glucose levels as an incretin. There is seemingly a very close nexus between GLP-1 function and altered preferences for not only hyperpalatable foods but also these drugs.

 

[Garbo]

@Type-IIx explains the benefits of GLP-1 and GIP agonists like Semaglutide and Tirzepatide, as true insulin sensitizing agents. how they are different from other weight loss drugs, and the benefits as partitioning agents for bodybuilders.

I'm sure you've read a lot about Ozempic, Wegovy, and Mounjaro for overweight sedentary people in the mainstream media but if you want to read about the use of these drug from a bodybuilding perspective, read on:

Semaglutide and Tirzepatide are More Than Just Weight Loss Drugs

Learn how GLP-1 and GIP agonists like Semaglutide and Tirzepatide enhance insulin sensitivity, preserve muscle mass and reduce fat stores.

thinksteroids.com

Excellent article, thanks so much.

 

[Enhanced_Swede24]

Interesting article and definitely worth experimenting with! Thank you!

 

[Ghoul]

@Type-IIx

Does semaglutide inheritly improve insulin sensitivity?

For those who experience a reduced desire for their addictions such as alcohol, smoking, etc - is there any direct cause from a GLP-1 agonist?

Thanks again for all the information!

Yes. The brain stem is rich in GLP receptors, which when activated, moderate reward seeking behavior and lessen the unpleasant withdrawal effects that maintain addictive cycles for many dopamine releasing substances and behaviors, from alcohol to cocaine, gambling to hyper-sexuality.

 

[Type-IIx]

Interesting article and definitely worth experimenting with! Thank you!

Excellent article, thanks so much.

You're very welcome!

 

[Nunya]

Great article, tracks with my personal experience on tirzepatide

 

[Avies48]

Great article, tracks with my personal experience on tirzepatide

What was ur experience with iron and cholesterol?