MESO-Rx Exclusive Ozempic and Mounjaro for bodybuilders - more than just weight loss drugs

[MESO-Rx Administrator]

@Type-IIx explains the benefits of GLP-1 and GIP agonists like Semaglutide and Tirzepatide, as true insulin sensitizing agents. how they are different from other weight loss drugs, and the benefits as partitioning agents for bodybuilders.

I'm sure you've read a lot about Ozempic, Wegovy, and Mounjaro for overweight sedentary people in the mainstream media but if you want to read about the use of these drug from a bodybuilding perspective, read on:

Semaglutide and Tirzepatide are More Than Just Weight Loss Drugs

Learn how GLP-1 and GIP agonists like Semaglutide and Tirzepatide enhance insulin sensitivity, preserve muscle mass and reduce fat stores.

thinksteroids.com

 

[Nunya]

What was ur experience with iron and cholesterol?

I'll know more on Monday when I get bloodwork done. I haven't experienced any symptoms of anemia though. Just never ending thirst, really.

 

[Avies48]

I'll know more on Monday when I get bloodwork done. I haven't experienced any symptoms of anemia though. Just never ending thirst, really.

Thats good to know!

 

[ve79]

As always I appreciate the articles.


I have been on Tirzepatide 7.5mg a week for some time. I re-added growth and on a low dose cycle. 200 test, 300 mast and am noticing some phenomenal size growth.

I'm thinking of getting some tits but would it also work good with mk677 to burn fat?

 

[Spaceman Spiff]

I'm thinking of getting some tits but would it also work good with mk677 to burn fat?

What?

 

[ve79]

What?

OMG sorry man I meant to say tirze and stack it with mk677 for fat loss rather than GH

 

[Fat]

It does! It couples insulin secretion to glucose levels as an incretin. There is seemingly a very close nexus between GLP-1 function and altered preferences for not only hyperpalatable foods but also these drugs.

Thank you

Do you think those that were running metformin for bodybuilding purposes during bulks and cuts can stop it and just use a GLP-1?

 

[Ghoul]

Thank you

Do you think those that were running metformin for bodybuilding purposes during bulks and cuts can stop it and just use a GLP-1?

Metformin increases natural GLP-1 secretion, which accounts for a number of its positive effects. You could drop it or stay on. They work synergistically, with the only potential downside increased GLP-1 sides, which you'd expect from what amounts to. a higher dose of the GLP.

If it didn't make me feel kind of sick (I tried it for a few months before going to Sema), I'd use it, since it brings other health benefits to the table. I may add it back in fact...

 

[Fat]

Metformin increases natural GLP-1 secretion, which accounts for a number of its positive effects. You could drop it or stay on. They work synergistically, with the only potential downside increased GLP-1 sides, which you'd expect from what amounts to. a higher dose of the GLP.

If it didn't make me feel kind of sick (I tried it for a few months before going to Sema), I'd use it, since it brings other health benefits to the table. I may add it back in fact...

Thank you

Doesn't natural GLP-1 secretion do nothing and only lasts minutes?

In regards to sensitizing muscles to insulin do you think I can drop it as Sema/Tirz can do that just as well or do you recommend I keep it?

Also doesn't metformin lower igf/mtor..

Do GLP1's do that?

 

[Ghoul]

Thank you

Doesn't natural GLP-1 secretion do nothing and only lasts minutes?

In regards to sensitizing muscles to insulin do you think I can drop it as Sema/Tirz can do that just as well or do you recommend I keep it?

Also doesn't metformin lower igf/mtor..

Do GLP1's do that?

GLP-1 has a very short half life, but its secretion is continuous while there's food in the intestines. Its effects are the same as extrogenous GLP while food is still being processed. Metformin increases the amount of GLP released from this process.

The net effect is an average 3% weight loss vs the ~15% from a GLP class drug.

Like taking a GH secretagogue(ie Ipamorelin / Tesamorelin) boosting naturally produced GH, while also injecting HGH.

I'm going to defer to someone who knows more re: insulin. It's not something I've really looked into, other than it can be problematic when used at the same time as a GLP drug, while Metformin is essentially safe to be used at the same time.

 

[Type-IIx]

Thank you

Do you think those that were running metformin for bodybuilding purposes during bulks and cuts can stop it and just use a GLP-1?

Yup! Metformin is irrational for bodybuilding for those not on AAS and/or GH:

Article: Risk vs. Reward Profile: Metformin

GLP-1 agonists combine synergistically with GH for recomp:

Article: Combined RhGH and GLP-1 Agonist: Rationales and Practical Use for Recomp (simultaneous fat loss and muscle gain)

 

[Fat]

Yup! Metformin is irrational for bodybuilding for those not on AAS and/or GH:

Article: Risk vs. Reward Profile: Metformin

GLP-1 agonists combine synergistically with GH for recomp:

Article: Combined RhGH and GLP-1 Agonist: Rationales and Practical Use for Recomp (simultaneous fat loss and muscle gain)

Thanks Type-IIx

Out of curiosity have you updated your take on Tirzepatide? according to Ghoul GIP functions in fat cells to increase fat accrual but also stimulates lipolysis.

Would you avoid this compound for lean bulking as it enhances fat storage?

 

[Type-IIx]

Thanks Type-IIx

Out of curiosity have you updated your take on Tirzepatide? according to Ghoul GIP functions in fat cells to increase fat accrual but also stimulates lipolysis.

Would you avoid this compound for lean bulking as it enhances fat storage?

I’m going to put out a podcast Monday re: this matter that I have written about briefly here:

Post in thread 'Ozempic and Mounjaro for bodybuilders - more than just weight loss drugs'
MESO-Rx Exclusive - Ozempic and Mounjaro for bodybuilders - more than just weight loss drugs

P.S. I think you guys will, if attentive, find that the nouveau “gurus” are following my work closely and trying to mimic it to larger audiences. Or steal it outright as in the case of Kurt Havens.

@Millard amirite?

 

[Ghoul]

I’m going to put out a podcast Monday re: this matter that I have written about briefly here:

Post in thread 'Ozempic and Mounjaro for bodybuilders - more than just weight loss drugs'
MESO-Rx Exclusive - Ozempic and Mounjaro for bodybuilders - more than just weight loss drugs

P.S. I think you guys will, if attentive, find that the nouveau “gurus” are following my work closely and trying to mimic it to larger audiences.

"GIP increases whole-body lipid oxidation, increases AT blood flow and lipid uptake, reduces food consumption via signaling actions in the brain, and reduces body weight."

https://joe.bioscientifica.com/view/journals/joe/261/3/JOE-23-0361.xml

Good luck unscrambling what the net effect of all this is at a low dose and in a calorie surplus, I don't envy you.

 

[Type-IIx]

I’m going to put out a podcast Monday re: this matter that I have written about briefly here:

Post in thread 'Ozempic and Mounjaro for bodybuilders - more than just weight loss drugs'
MESO-Rx Exclusive - Ozempic and Mounjaro for bodybuilders - more than just weight loss drugs

P.S. I think you guys will, if attentive, find that the nouveau “gurus” are following my work closely and trying to mimic it to larger audiences. Or steal it outright as in the case of Kurt Havens.

@Millard amirite?

Anyone

"GIP increases whole-body lipid oxidation, increases AT blood flow and lipid uptake, reduces food consumption via signaling actions in the brain, and reduces body weight."

https://joe.bioscientifica.com/view/journals/joe/261/3/JOE-23-0361.xml

Good luck unscrambling what the net effect of all this is at a low dose and in a calorie surplus, I don't envy you.

I unscramble bullshit all day long, beware

Just depends on where I focus my energy

 

[Type-IIx]

@Dirthand good chatting earlier bro! Looking forward to next week

 

[Dirthand]

@Dirthand good chatting earlier bro! Looking forward to next week

For sure dawg!! 4-2 tha floor...
Peace

 

[Type-IIx]

For sure dawg!! 4-2 tha floor...
Peace

Hey bro! I don’t understand, but DH is my boyyyyeeee

 

[Dirthand]

Hey bro! I don’t understand, but DH is my boyyyyeeee

4-2 the floor = wide open

 

[lilchikin]

Yup! Metformin is irrational for bodybuilding for those not on AAS and/or GH:

Article: Risk vs. Reward Profile: Metformin

GLP-1 agonists combine synergistically with GH for recomp:

Article: Combined RhGH and GLP-1 Agonist: Rationales and Practical Use for Recomp (simultaneous fat loss and muscle gain)

Dude post more on PM lol we need this there

 

[Hardtimes]

I did a 6 week run of tirz only 10 mg in total and I was very impressed, I didn’t change my diet although it did get rid of the little voice that tells me to eat a chocolate bar after my evening meals. The main things I noticed were my bloating disappeared as I’m always pretty low body fat at 10-12% but always was a bit watery or protruding abs and that disappeared. I stopped after the 6 weeks and the bloat came back so I just started again but I’m going to try 2 mg every 5 or 6 days as last time I noticed last time that it worked great days 2-5 after a shot then didn’t notice anything days 6 and 7.

I tried it along with metformin but the 2 together didn’t feel the best.