Ozempic (semaglutide) wtf?

[lukiss96]

So I have finally decided to use it this strange pen, I injected 36 clicks which is 0.5mg (right?) and after couple hours I already feel like I hate eating?

Is it normal? Is it placebo x10 effect? I had this steak on my mind now I don't even want it?

What is food? Do we need to eat? Can I not eat and not die? Am I invincible?

But really though when is it supposed to work and do the effects wear off over time?

Do I need to inject it more frequently
than once a week?

 

[freakyjacked29]

Another one that will speed up gastric emptying and stop the sickness

metoclopramide
But you can’t use this long term but short term it works.

 

[HB_22]

I really wonder how it can have so little side effects (long term). I was under the impression that there might be some down regulation and if you stop taking it end up having worse bg levels than before even starting with the GLP-1 agonists. But that doesn’t seem to be the case. Even the 68 weeks studies and whatever don’t seem to have found any long term down regulation. Really weird.

 

[lukiss96]

I honestly feel like he isnt, he seems alot more collected than myself.

As I have mentioned before, I came a long way managing my anger and self control. I now help people or at least try to

The part of the town I grew up was the one where you could get knife stuck up in you, shot, beaten, robbed, less often killed all that daily and some other bad stuff.

You seem like cool person to hang out with, very well mannered person, kind and with a good sense of humor, not to mention your interesting hobby. Even though I don't know you, but it feels like you're real person I met somewhere, maybe in alternative universe?

It's hard to explain for me, but your eye sight is wide, like you know the exact opposite of most people that have this narrow/tunnel like thinking.

I'll better stop, because for some reason some people here just hate seeing long reply's like that and think I'm about to screw up the thread and want me to shut the f* up.

Maybe they're not sociable and prefer to be loners, hard to say, but negative people are all around the world anyway.

However, I love to talk and I just can't stop sometimes

 

[Harley00]

Tirzepatide is going to blow Semaglutide outa the water when it gets released. Im patiently waiting.

 

[lukiss96]

Tirzepatide is going to blow Semaglutide outa the water when it gets released. Im patiently waiting.

Unfortunately, I think it's gonna be very expensive, not that ozempic is cheap. It still is quite expensive for what it is...

My unpopular opinion, is that there is not really a need for these. At least for me, I can do without them and feel better. They're good use for someone serious with bodybuilding lifestyle and competitors, but how many are like this here? I'd say at best 2-3%.

 

[Harley00]

Unfortunately, I think it's gonna be very expensive, not that ozempic is cheap. It still is quite expensive for what it is...

My unpopular opinion, is that there is not really a need for these. At least for me, I can do without them and feel better. They're good use for someone serious with bodybuilding lifestyle and competitors, but how many are like this here? I'd say at best 2-3%.

Tirzepatide is going to change, peoples lifes with insulin resistance as its works on duel receptors, so glp 1 and gip . The problem with insulin resistance is , the insulin dosn't make it into the cells, glp 1 may stimulate your pancreas to produce insulin but if you have high levels of insulin resistance it wont do much. I think this new product will help people more with the insulin resistance side of things, and allow the insulin to enter the cells.

Ozempic only cost me 40$ with my insurance and if i wanted to fill out a bunch of paper work i could have got it for free, canada may be a bit better then some other area's

 

[lukiss96]

Tirzepatide is going to change, peoples lifes with insulin resistance as its works on duel receptors, so glp 1 and gip . The problem with insulin resistance is , the insulin dosn't make it into the cells, glp 1 may stimulate your pancreas to produce insulin but if you have high levels of insulin resistance it wont do much. I think this new product will help people more with the insulin resistance side of things, and allow the insulin to enter the cells.

Ozempic only cost me 40$ with my insurance and if i wanted to fill out a bunch of paper work i could have got it for free, canada may be a bit better then some other area's

Yes, for sure for patients it's awesome I guess?

I'm too uneducated on this topic, I have only stupidly jumped on this ozempic for whatever reasons lol...

I'm otherwise healthy, maybe that's why I feel like I take it unnecessarily.

All I need is steroids, anti estrogens, cialis and I'm good

 

[lukiss96]

Got a bit softer, as I've hit gym only twice in 2 weeks!

I was out and my diet was hard to control.

Feel a bit flat and bf is ~16% I think weight is 233 height is almost 6'2.

Currently cutting to reach 12-13% ! Hopefully I'll be in mid 220's at goal bf %

No pump, okay lighting, no filters, flat af, after protein oat pudding...

 

[HB_22]

Tirzepatide is going to blow Semaglutide outa the water when it gets released. Im patiently waiting.

Think so, too. But cost-wise it won’t beat semaglutide. Speaking of buying it w/o insurance or on the black market (mostly China).

But for sure, if one is able to get it with insurance covering the costs it will beat semaglutide.

I honestly think both are not only strict for diabetics. This is a new drug class that will very likely be prescribed and used a lot even in healthy people to push health more, if that makes any sense. It lowered my blood pressure so much that I had to get rid of my 10mg Amlodipine that I otherwise would take for blood pressure on cycle.

 

[M@NU]

Think so, too. But cost-wise it won’t beat semaglutide. Speaking of buying it w/o insurance or on the black market (mostly China).

But for sure, if one is able to get it with insurance covering the costs it will beat semaglutide.

I honestly think both are not only strict for diabetics. This is a new drug class that will very likely be prescribed and used a lot even in healthy people to push health more, if that makes any sense. It lowered my blood pressure so much that I had to get rid of my 10mg Amlodipine that I otherwise would take for blood pressure on cycle.

ozempic is already improved for heart failure w/o diabetes in the US.
thats why i will ask my doc on wednesday if there is any possibility to get it prescribed

 

[Para_33]

I was wondering about that portion with nutrient partitioning. Even if you stayed at 0.5mg a week and assist with nutrient shuttling and keeping bg in control versus something like lantus.
I am not sure if it does decrease sensitivity because it is endogenous insulin. I think it mainly occurs with exogenous.

Idk If @Type-IIx has any thoughts.

I personally through anecdotes and what I’ve seen on the matter, don’t think exogenous insulin use is actually the cause of insulin resistance. The science of it, as of now isn’t fully understood what causes resistance.

I think there are a few short term causes of resistance like hgh administration causing increase free fatty acid, and those reducing glut4 passive uptake of Nutrients/glucose, causing insulin to have to go all the work. And also acute resistance from hyperinsulinemia or excess insulin levels. But I feel those resolve in a matter of days or a day or two.

The longer term insensitivity can be exampled by people who are right post contest going hypo after eating meals- because they’ve accumulated such a high amount of insulin sensitivity that they actually make themselves go hypo with endogenous insulin. If you apply the same thing in reverse, when people have lots of stress favors over time, inflammation etc, I bet the body down regulates actual cell insulin receptors at the surface and the various Glut-1,2,3,4 receptors.

I forget which exactly if the glut receptors are in the brain- but it makes sense why it’s speculated Alzheimer’s is like a form of diabetes. people with long term bad health have increased risk, and that’s associated with insulin resistance also.

 

[WeightLossBurn]

Got a bit softer, as I've hit gym only twice in 2 weeks!

I was out and my diet was hard to control.

Feel a bit flat and bf is ~16% I think weight is 233 height is almost 6'2.

Currently cutting to reach 12-13% ! Hopefully I'll be in mid 220's at goal bf %

No pump, okay lighting, no filters, flat af, after protein oat pudding...
View attachment 169308

You look great, but if you can I would recommend taking the picture off the forum and replacing it with one covering your face and blurring out the tats. It's safer that way.

I didn't read the whole thread. But I assume because of the high starter dose you took, you will have appetite control due to nausea for a few days and then nothing. That's nothing until you have it in your body for at least 2 weeks.

 

[phenominal34]

Just ordered Rybelsus from BG, he was out of Ozempic. I’ll report back eventually on results. I’ll be starting at 7 mgs a day

 

[Doodle]

Just ordered Rybelsus from BG, he was out of Ozempic. I’ll report back eventually on results. I’ll be starting at 7 mgs a day

My Rybelsus arrived yesterday. I started 7mg today. So I’m interested to see what happens with others as well. I took my first dose at 7:30 this morning. I’m eager for more people to start reporting.

 

[lukiss96]

You look great, but if you can I would recommend taking the picture off the forum and replacing it with one covering your face and blurring out the tats. It's safer that way.

I didn't read the whole thread. But I assume because of the high starter dose you took, you will have appetite control due to nausea for a few days and then nothing. That's nothing until you have it in your body for at least 2 weeks.

Ty, it's good to know. I already feel much better today.

I don't mind showing myself, I'm open.

 

[phenominal34]

My Rybelsus arrived yesterday. I started 7mg today. So I’m interested to see what happens with others as well. I took my first dose at 7:30 this morning. I’m eager for more people to start reporting.

Reminder to take on empty stomach and don’t eat for 30 mins after taking for best absorption

 

[Doodle]

Reminder to take on empty stomach and don’t eat for 30 mins after taking for best absorption

Thanks! I woke up and took it with just a sip of water and then went back to sleep. Then woke up and started my day. I don’t expect anything for a couple of days so I’m not experiencing anything yet of course.

 

[HB_22]

Isn't the oral Ozempic expensive as fuck?

 

[Doodle]

Isn't the oral Ozempic expensive as fuck?

It was $170 for (30) 14mg tabs. I’m doing 7mg a day so it’s $170 for 2 months. It’s expensive but not too horrible.

 

[HB_22]

Does anyone know how quickly the tolerance is fading away? Like when I used to take 1mg/week for several weeks and then stop for 2 weeks, do you guys think I will be already fresh to start with only 0.25mg again? Im not even sure if there is any tolerance at all or just as soon as the drug leaves the body I have to restart again with 0.25mg?