Post up your Natty IGF-1 Level

[FunkOdyssey]

Thanks for the book link, I will read it for sure. So you think GH at low doses (3iu and under) should not be used by older people for the recovery benefits or for anyone looking for the weight loss benefits?Just looking for your personal belief and the reasons why since you have read the book.

If there is a dose of GH you can take which does not significantly affect insulin resistance, then that would be better (though still suspect to reduce longevity via other mechanisms).

I've heard from others that they are seeing negative IR effects as low as 2 IU daily. I'm sure the exact threshold where it becomes problematic is different for everyone, but the doses most people are interested in, which are high enough to make a dent in their body composition, are probably over that line. If you're only looking at fasting glucose, that alone probably won't be sensitive enough of a measurement to detect the negative effects in most people. Definitely want to also look at fasting insulin.

One of my key criteria for substance use is now simply, does it promote insulin resistance?

Androgens? No, gtg.
GH? Yes
Insulin? Yes
Caffeine? Yes (crying)

 

[glpfun]

Mine is 158

 

[glpfun]

question about the insulin resistance. Can this be mitigated by fasting a couple hours before bed and taking daily dose right before bed? Or are there other habits that can help manage the insulin resistance effects?

 

[Grey Spartan]

though still suspect to reduce longevity via other mechanisms

I read an article which I can not find for the life of me, that quoted a study done in women that concluded, high IGF-1 levels reduced lifespan and cognition.

Caffeine? Yes (crying)

LIES!!!!

 

[FunkOdyssey]

I read an article which I can not find for the life of me, that quoted a study done in women that concluded, high IGF-1 levels reduced lifespan and cognition.

Yes, it gets ugly if you look into it. There's a ton of studies around the GH/IGF-1 axis as pro-aging in animal models, longest-lived people have lower GH/IGF-1, etc.

LIES!!!!

I know, it pains me to say it. I'll share some of my notes on this, which are a mix of studies and AI chats. The problem: caffeine increases epinephrine levels chronically above baseline. It's basically liquid stress. You can actually prevent the insulin resistance caused by caffeine with a non-selective beta blocker (nebivolol won't work). Of course, those are shitty drugs to take for other reasons.

Caffeine / Insulin Resistance Notes


View: https://youtu.be/gi4WOD54xeA?si=bEkoIwb_rXusOk9I

 

[Ghoul]

There is a lot of evidence linking coffee consumption to (not caffeine specifically) younger biological age and longevity. But this round up of expert reactions to one of the more significant studies helps put it in context:

expert reaction to study on coffee drinking and increased longevity | Science Media Centre

 

[FunkOdyssey]

There is a lot of evidence linking coffee consumption to (not caffeine specifically) younger biological age and longevity. But this round up of expert reactions to one of the more significant studies helps put it in context:

expert reaction to study on coffee drinking and increased longevity | Science Media Centre

The polyphenols in coffee have insulin-sensitizing effects that help counteract the negative effects of caffeine somewhat. Decaf coffee shows the most positive effects for this reason. Individual differences in the speed of caffeine metabolism become relevant here, to determine whether caffeinated coffee will be beneficial or harmful.

Epidemiological studies on coffee are confounded by many factors, one of which is survivorship bias. The ability to tolerate caffeinated coffee at advanced ages can become a type of stress test that sicker people don't pass.

 

[Benf15harp]

Just for the record: I couldn’t give a flying fuk about longevity

 

[Jin23]

question about the insulin resistance. Can this be mitigated by fasting a couple hours before bed and taking daily dose right before bed? Or are there other habits that can help manage the insulin resistance effects?

Well yes, ofc, the best suited diet for GH would be IF. Something in the lines of 8/16 should be adequate, followed by a fasting workout with GH. The GH schedule should thus be in the morning as moving (not to mention working out) helps burn off the liberated ffa's which are the major factor in causing IR. Also you get enhanced fat burning by working out fasted with elevated GH levels.