Tirzepatide does not appear to result in excess loss of lean mass vs any standard weight loss method - most likely the opposite. I can provide details, however indications are it aids in recomposition:
The mean reduction in total body fat mass was 33.9% with tirzepatide, as compared with 8.2% with placebo, for an estimated treatment difference relative to placebo of −25.7 percentage points ...
The ratio of total fat mass to total lean mass decreased more with tirzepatide than with placebo.
...Participants treated with tirzepatide had a percent reduction in fat mass approximately three times greater than the reduction in lean mass, resulting in an overall improvement in body composition. The ratio of fat-mass loss to lean-mass loss was similar to that reported with lifestyle-based and surgical treatments for obesity.
21
Additionally it improves numerous organ health markers, lipid profiles, insulin sensitivity and increases adiponectin.
What the stigma really seems to be is we are a bodybuilding forum being overrun by the cast of my 600 lb life.