I've felt just slightly nauseous and flushed immediately after dosing, but I'd say that that's roughly the same for 1 or 2.
I'd always used 1, but a couple of months ago couldn't find any, so went with 2 for the first time. It at least seems to me to be much more difficult to control the effect by adjusting the dose of 2 vs. 1.
Dosing 2 as I did 1, which is starting with 1mg/day for a week, then shifting to 1mg/week to maintain, hasn't worked well at all. I'm dealing with comments daily on how tanned I am. I haven't taken a dose in almost 3w now, and am still looking like a medium-toned black man -