Please show me where evidence is that Cagri suppresses appetite more than semi? I’m on Cagri now and not feeling much gradually increasing weekly. Up to 2mgs a week and not much suppression if any !!
Firstly, let me preface by saying appetite is somewhat objective. So you're not going to see an article testing that hypothesis of which one suppresses appetite the greatest. Their MO being somewhat similar makes it not worth it when the goal itself is weight loss.
Basically, Sema and Cagri do relatively the same thing via separate but sometimes overlapping mechanisms.
Sema acts on GLP 1-R which then causes the receptors to trigger and has effects on beta cells in pancreas (inhibiting gastric emptying, reducing food intake, and limiting postprandial glucagon secretion) as well as an INDIRECT action via the vagus nerve to the hypothalamus to trigger satiety. Sema however has the advantage of triggering extra insulin release (i''ll get back to this)
Cagri is an amylin analogue. Amylin is DIRECT acting on areas in the hindbrain that trigger anorexia and undereating (hypophagy). Amylin crosses the blood brain barrier to do this action, but the verdict is still out there as to whether sema crosses. This direct activity towards central activity may hint towards a stronger effect. It (cagri) also has a longer half life so it's effect will take longer to wear off
Adding this knowledge to several anecdotes we can only postulate that this is probably why Cagri, despite it's very similar actions to sema, showed greater weight loss than sema in the trials.
However because of sema's 'insulin releasing' properties, it produces better A1C reduction.
In any case, since their actions overlap, and the recommendation is to combine both medications. When combined they synergise to great effect
If you are not feeling suppression at 2mg cagri, you may need to change your cagri source or increase your dosage. Also your bac water needs to be more acidic for cagri solublity.
The articles are behind a paywall. I can send then to you if you want
For decades, extensive research has aimed to clarify the role of pancreas and gut-derived peptide hormones in the regulation of glucose homeostasis and feeding behavior. Among these are the beta-cell hormone amylin and the intestinal L cell hormone glucagon-like peptide-1 (GLP-1). They exhibit...
pubmed.ncbi.nlm.nih.gov
I wanted to send all of this as a DM but you don't accept Direct messages..My apologies...