HB_22
Well-known Member
Well, I will link this one for you because someone posted it for me the other day in the giant semaglutide thread:Oh wow! I’m gonna have to give this a try. Have a bunch of Metformin laying around, good excuse to dig into it
I found this online
In patients with type 2 diabetes mellitus, metformin inhibits DPP-4 activity and thus increases active GLP-1 concentrations after subcutaneous injection. In combination with GLP-1, metformin significantly lowers plasma glucose concentrations in type 2 diabetes mellitus subjects compared with GLP-1 alone, whereas insulin responses were similar. Metformin enhances serum concentrations of injected active GLP-1(7-36)amide, and the combination results in added glucose-lowering potency.
According to this scientific paper, Metformin increases GLP-1 serum concentrations which leads to better blood glucose control. And to me it felt like the hunger suppression was also intensified.