forsure, just means the seal is not broken/handled better, BUT because its (vacuum) formed at freeze dry temperatures that kill 99% of bacteria(think canning pickles and canning jar lids done via temp gradients) higher probability of clean product if do have vacuum but does not guarantee with or without.
pharma for example for some products DONT have vac as your suppose to suck sterile air out of the peptide bottle and use that to pressurize the bac water container to ensure only sterile air gets into bac water and therefore peptide. so they dont have vac as would be impossible to suck air out of the peptide.